| Identification | Back Directory | [Name]
2-Methyl-5-(2-thienyl)-3-furancarboxylic acid | [CAS]
651005-90-2 | [Synonyms]
Jedi2
2-Methyl-5-(2-thienyl)-3-furancarboxylic acid | [Molecular Formula]
C10H8O3S | [MOL File]
651005-90-2.mol | [Molecular Weight]
208.23 |
| Chemical Properties | Back Directory | [Boiling point ]
356.9±42.0 °C(Predicted) | [density ]
1.336±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
powder | [pka]
4.38±0.26(Predicted) | [color ]
White |
| Hazard Information | Back Directory | [Uses]
Jedi2 is a Piezo1 activator, but not a specific Piezo2 activator. Jedi2 binds to the mouse Piezo1 proteins with a Kd of 2770??μM[1]. | [Definition]
ChEBI: 2-Methyl-5-(2-thienyl)-3-furoic acid is a furoic acid. | [Biological Activity]
Jedi2 is an activator of the mechanosensitive Piezo1 channel th at binds at a different place from Yoda1. It exhibits long-range allosteric gatingactivating Piezo1 through the extracellular side of its peripheral blade-like structure rather than the C-terminal extracellular domain of the pore. | [storage]
Store at -20°C | [References]
[1] Yanfeng Wang, et al. A lever-like transduction pathway for long-distance chemical- and mechano-gating of the mechanosensitive Piezo1 channel. Nat Commun. 2018 Apr 3;9(1):1300. DOI:10.1038/s41467-018-03570-9 |
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