6724-53-4
中文名称
马来酸哌克昔林
英文名称
PERHEXILINE MALEATE SALT
CAS
6724-53-4
分子式
C23H39NO4
分子量
393.56
MOL 文件
6724-53-4.mol
更新日期
2024/04/21 20:44:09
6724-53-4 结构式
基本信息
中文别名
马来酸哌西林马来酸哌克昔林
肉碱棕榈酰转移酶1抑制剂(PERHEXILINE MALEATE)
英文别名
PexidWSM-3978
WSM 3978G
perhexilinemaleate
perhexilene maleate
rac Perhexiline Maleate
PERHEXILINE MALEATE SALT
PERHEXILINE MALEATE SALT USP/EP/BP
2-(2,2-dicyclohexylethyl)piperidinemaleate
2-(2,2-dicyclohexylethyl)-piperidinmaleate(1:1)
所属类别
原料药：防治心绞痛药安全数据
WGK Germany2
WGK Germany2
RTECS号TM7068000
毒性LD50 in rats, mice (g/kg): >7, 4.37 orally (Causa, Perri)
常见问题列表
生物活性
Perhexiline maleate 是一种有效的 carnitine palmitoyltransferase 1 (CPT1) 的抑制剂，对大鼠心脏CPT1和肝脏CPT1的IC50值分别为77 μM和148 μM。靶点
| Target | Value |
|
rat heart CPT1
(Cell-free assay) | 77 μM |
|
rat liver CPT1
(Cell-free assay) | 148 μM |
体外研究
At 24, 48 and 72 h of treatment with 0.01 and 1 μM of Perhexiline , NDM29 ncRNA expression level in SH-SY5Y cells is progressively increased, reaching a peak after 48 hours of treatment. Perhexiline treatment increases the susceptibility of NB cells to antiblastic treatments. Co-administration of Perhexiline maleate potentiates the efficacy of cisplatin to reduce the in vitro clonogenic potential of NB cells.
体内研究
The co-administration of Perhexiline and cisplatin yields a clear enhancement of antitumor effects, resulting in a significantly improved progression-free survival as compared with mice treated with DMSO. Perhexiline favors NB cell transition to differentiated phenotype.