6724-53-4
中文名称
马来酸哌克昔林
英文名称
PERHEXILINE MALEATE SALT
CAS
6724-53-4
分子式
C23H39NO4
分子量
393.56
MOL 文件
6724-53-4.mol
更新日期
2026/10/30 17:26:01
6724-53-4 结构式
基本信息
中文别名
马来酸哌西林马来酸哌克昔林
肉碱棕榈酰转移酶1抑制剂(PERHEXILINE MALEATE)
英文别名
PexidWSM-3978
WSM 3978G
perhexilinemaleate
perhexilene maleate
rac Perhexiline Maleate
PERHEXILINE MALEATE SALT
PERHEXILINE MALEATE SALT USP/EP/BP
2-(2,2-dicyclohexylethyl)piperidinemaleate
2-(2,2-dicyclohexylethyl)-piperidinmaleate(1:1)
所属类别
原料药：防治心绞痛药物理化学性质
熔点181-183°C
储存条件2-8°C
溶解度二甲基亚砜：≥5mg/mL
形态粉末
颜色白色至棕褐色
InChI1S/C19H35N.C4H4O4/c1-3-9-16(10-4-1)19(17-11-5-2-6-12-17)15-18-13-7-8-14-20-18;5-3(6)1-2-4(7)8/h16-20H,1-15H2;1-2H,(H,5,6)(H,7,8)/b;2-1-
InChIKeyJDZOTSLZMQDFLG-BTJKTKAUSA-N
SMILESOC(=O)\C=C/C(O)=O.C1CCC(CC1)C(CC2CCCCN2)C3CCCCC3
安全数据
WGK Germany2
WGK Germany2
RTECS号TM7068000
存储类别11 - Combustible Solids
毒性LD50 in rats, mice (g/kg): >7, 4.37 orally (Causa, Perri)
马来酸哌克昔林价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2026/09/15 | HY-B1334A | 马来酸哌克昔林 Perhexiline maleate | 6724-53-4 | 1 mg | 454元 |
| 2026/09/15 | HY-B1334AR | 马来酸哌克昔林 Perhexiline maleate (Standard) | 6724-53-4 | 5 mg | 2300元 |
| 2026/09/15 | HY-B1334A | 马来酸哌克昔林 Perhexiline maleate | 6724-53-4 | 5mg | 1000元 |
常见问题列表
生物活性
Perhexiline maleate 是一种有效的 carnitine palmitoyltransferase 1 (CPT1) 的抑制剂，对大鼠心脏CPT1和肝脏CPT1的IC50值分别为77 μM和148 μM。靶点
| Target | Value |
|
rat heart CPT1
(Cell-free assay) | 77 μM |
|
rat liver CPT1
(Cell-free assay) | 148 μM |
体外研究
At 24, 48 and 72 h of treatment with 0.01 and 1 μM of Perhexiline , NDM29 ncRNA expression level in SH-SY5Y cells is progressively increased, reaching a peak after 48 hours of treatment. Perhexiline treatment increases the susceptibility of NB cells to antiblastic treatments. Co-administration of Perhexiline maleate potentiates the efficacy of cisplatin to reduce the in vitro clonogenic potential of NB cells.
体内研究
The co-administration of Perhexiline and cisplatin yields a clear enhancement of antitumor effects, resulting in a significantly improved progression-free survival as compared with mice treated with DMSO. Perhexiline favors NB cell transition to differentiated phenotype.