70209-81-3
中文名称
伊维菌素B1B
英文名称
Avermectin A1a, 5-O-demethyl-25-de(1-methylpropyl)-22,23-dihydro-25-(1-methylethyl)-
CAS
70209-81-3
分子式
C47H72O14
分子量
861.07
MOL 文件
70209-81-3.mol
更新日期
2025/05/07 12:56:55
70209-81-3 结构式
基本信息
中文别名
伊维菌素杂质2依维菌素B1B
伊维菌素B1B
英文别名
Component B1bIvermectin B1b
IvermectinH2B1b
avermectin H2B1b
Dihydroavermectin B1b
22,23-Dihydroavermectin B1b
22,23- dihydroavermectin B1b (Ivermectin B1b)
22,23-Dihydro-34-nor-5-O-demethylavermectin A1a
DihydroaverMectin B1b, 22,23-DihydroaverMectin B1b
22,23-Dihydro-5-O-demethyl-25-de(1-methylpropyl)-25-isopropylavermectin A1a
所属类别
医药中间体：杂环化合物物理化学性质
沸点934.1±65.0 °C(Predicted)
密度1.24±0.1 g/cm3(Predicted)
储存条件-20°C储存
溶解度DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble
酸度系数(pKa)12.42±0.70(Predicted)
形态固体
颜色White to off-white
稳定性对温度敏感
常见问题列表
生物活性
Ivermectin B1b 是 Ivermectin 的次要成分。Ivermectin 是一种有效的抗寄生虫药物，可抑制 SARS-CoV-2 复制。体外研究
Ivermectin and Ivermectin B1b are the most potent inhibitors of contraction and motility in both susceptible isolates (
H. contortus
McMaster and and
O. circumcincta
McMaster) also show the highest resistance ratios in both species.
Vermectin is a macrocyclic lactone that acts as a positive allosteric modulator of α7 nicotinic acetylcholine receptors (nAChRs) but has no modulatory activity on 5-HT3 receptors.
体内研究
Ivermectin B1b causes snail death.