77603-42-0
77603-42-0 结构式
基本信息
8-Nitrotryptanthrin
GNF-PF-3777 (8-Nitrotryptanthrin)
Indolo[2,1-b]quinazoline-6,12-dione, 8-nitro-
物理化学性质
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/01/25 | HY-100687 | 8-NITROTRYPTANTHRIN GNF-PF-3777 | 77603-42-0 | 1mg | 900元 |
| 2024/01/25 | HY-100687 | 8-NITROTRYPTANTHRIN GNF-PF-3777 | 77603-42-0 | 5mg | 2500元 |
| 2024/01/25 | HY-100687 | 8-NITROTRYPTANTHRIN GNF-PF-3777 | 77603-42-0 | 10mM * 1mLin DMSO | 2900元 |
常见问题列表
|
rhIDO2 1.8 μM (IC 50 ) |
rhIDO2 0.97 μM (Ki) |
The typtanthrin derivative GNF-PF-3777 (8-Nitrotryptanthrin; Compound 5i) is found to be a potent hIDO2 inhibitor with superior efficiency far better than that of the most frequently-used inhibitor L-1-MT. The IC 50 values show that all nine tryptanthrin compounds display hIDO2 inhibitory activities, GNF-PF-3777 demonstrates much stronger inhibition (1.87 μM) than both L-1-MT (82.53 μM) and D-1-MT (262.75 μM). GNF-PF-3777 exhibits significant antitrypanosomal activity with EC 50 of 0.82 μM. GNF-PF-3777 (8-Nitrotryptanthrin) has a microplate Alamar Blue assay (MABA) minimum inhibitory concentration (MIC) value of 0.032 μg/mL. GNF-PF-3777 also has a LORA MIC value of 2.4 μg/mL, while the majority of analogues lack LORA activity.