82752-99-6
中文名称
萘法唑酮盐酸盐
英文名称
Nefazodone hydrochloride
CAS
82752-99-6
分子式
C25H33Cl2N5O2
MDL 编号
MFCD00865396
分子量
506.47
MOL 文件
82752-99-6.mol
更新日期
2023/09/07 17:02:00
82752-99-6 结构式
基本信息
中文别名
盐酸奈法唑酮萘法唑酮盐酸盐
英文别名
erazoneNEFAZODONE
BMY 13754-1
>=98% (HPLC)
Nefazodone HCl
NEFAZODONE-D5 HCL
Nefazodone hydrochlo
Nefazodone hydrochloride
Nefazodone hydrochloride API
Nefazodone Hydrochloride (200 mg)
1-(3-(4-(3-Chlorophenyl)piperazin-1-yl)propyl)-3-ethyl-4-(2-phenoxyethyl)-1H-1,2,4-triazol-5(4H)-
1-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}-3-ethyl-4-(2-phenoxyethyl)-4,5-dihydro-1H-1,2,4-triazol-5-one
1-(3-(4-(3-Chlorophenyl)piperazin-1-yl)propyl)-3-ethyl-4-(2-phenoxyethyl)-1H-1,2,4-triazol-5(4H)-one hydrochloride
2,4-Dihydro-2-(3-(4-(3-chlorophenyl)-1-piperazinyl)propyl)-5-ethyl-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one hydrochloride
3H-1,2,4-Triazol-3-one, 2-3-4-(3-chlorophenyl)-1-piperazinylpropyl-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-, monohydrochloride
BMY-13754, MJ-13754-1, Serzone, 2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-ethyl- 2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one hydrochloride
所属类别
化学试剂：多环化合物物理化学性质
熔点186-188°C
储存条件Inert atmosphere,Room Temperature
溶解度DMSO: ~11 mg/mL at 60 °C
形态solid
形态固体
颜色white
颜色白色
最大波长(λmax)248nm(MeOH)(lit.)
Merck14,6438
安全数据
警示词警告
危险性描述H302-H315-H319-H335
安全说明S22-S24/25
危险品运输编号UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany3
RTECS号XZ5483009
海关编码2933595960
常见问题列表
生物活性
Nefazodone hydrochloride (BMY-13754) 是一种强效和选择性的 5HT2A (Ki=5.8 nM) 拮抗剂，对 5-HT 和去甲肾上腺素摄取具有中度抑制作用 (IC50 分别为 290 和 300 nM)。Nefazodone hydrochloride 是一种苯哌嗪类抗抑郁药，具有微弱的 α-肾上腺素阻断活性。靶点
|
5-HT 2A Receptor 5.8 nM (Ki) |
α1-adrenergic receptor
|
体外研究
Nefazodone hydrochloride (BMY-13754) is a phenylpiperazine antidepressant with a mechanism of action that is distinct from those of other currently available drugs. Nefazodone hydrochloride potently and selectively blocks postsynaptic serotonin (5-hydroxytryptamine; 5-HT) 5-HT2A receptors and moderately inhibits serotonin and noradrenaline (norepinephrine) reuptake. Nefazodone hydrochloride is also an inhibitor of the hepatic P-450 isoenzyme CYP3A4.