847239-17-2
中文名称
UVI 3003
英文名称
3-[4-Hydroxy-3-[5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-(pentyloxy)-2-naphthalenyl]phenyl]-2-propenoicacid
CAS
847239-17-2
分子式
C28H36O4
分子量
436.58
MOL 文件
847239-17-2.mol
更新日期
2025/05/06 11:18:50
847239-17-2 结构式
基本信息
中文别名
化合物UVI 30033-[4-羟基-3-[5,6,7,8-四氢-5,5,8,8-四甲基-3-(戊基氧基)-2-萘]苯基]-2-丙酸
英文别名
UVI 3003UVI 3003
UVI-3003
UVI3003
3-[4-Hydroxy-3-[5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-(pentyloxy)-2-naphthalenyl]phenyl]-2-propenoicacid
2-Propenoic acid, 3-[4-hydroxy-3-[5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-(pentyloxy)-2-naphthalenyl]phenyl]-
3-[4-Hydroxy-3-[5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-(pentyloxy)-2-naphthalenyl]phenyl]-2-propenoicacid ISO 9001：2015 REACH
所属类别
催化剂及助剂：紫外线吸收剂物理化学性质
储存条件Inert atmosphere,Store in freezer, under -20°C
溶解度DMF: 25 mg/ml; DMSO: 15 mg/ml; Ethanol: 20 mg/ml
形态结晶固体
颜色White to off-white
UVI 3003价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/02/08 | HY-107500 | UVI 3003 | 847239-17-2 | 1 mg | 545元 |
| 2025/02/08 | HY-107500 | UVI 3003 UVI 3003 | 847239-17-2 | 5mg | 1200元 |
| 2025/02/08 | HY-107500 | UVI 3003 UVI 3003 | 847239-17-2 | 10mM * 1mLin DMSO | 1320元 |
常见问题列表
生物活性
UVI 3003 是一种高度选择性的 retinoid X receptor (RXR) 抑制剂，在 Cos7 细胞中，抑制非洲爪蟾蜍和人 RXRα 的活性，IC50 值分别为 0.22 和 0.24 μM。靶点
IC50: 0.22 μM (Xenopus RXRα, in Cos7 cells), 0.24 μM (Human RXRα, in Cos7 cells)
体外研究
UVI3003 inhibits the activity of xenopus and human RXRα, with IC 50 s of 0.22 and 0.24 μM, respectively. UVI3003 fully activates xPPARγ with an EC 50 of 12.6 μM, and is almost completely inactive on hPPARγ and mPPARγ. UVI 3003 (10 μM) does not change the proliferation rate of extraocular muscles (EOM)-derived or LEG-derived EECD34 cells. UVI 3003 causes a 65.4% difference in EECD34 cell fusion and desmin expression.