946518-60-1
中文名称
IKK2抑制剂（LY2409881）
英文名称
LY2409881 trihydrochloride
CAS
946518-60-1
分子式
C24H32Cl4N6OS
分子量
521.51
MOL 文件
946518-60-1.mol
更新日期
2025/04/27 09:49:44
946518-60-1 结构式
基本信息
中文别名
LY2409881三盐酸盐IKK2抑制剂(LY2409881)
化合物LY2409881 TRIHYDROCHLORIDE
2-(5-氯-2-((3-(4-甲基哌嗪-1-基)丙基)氨基)嘧啶-4-基)-N-环丙基苯并[B]噻吩-4-羧酰胺 三盐酸盐
2-[5-氯-2-[[3-(4-甲基-1-哌嗪基)丙基]氨基]-4-嘧啶基]-N-环丙基-苯并[B]噻吩-4-甲酰胺三盐酸盐
英文别名
LY2409881CS-1620
LY2409881 3HCl
LY-2409881 HC'l
LY2409881 triHCl
LY-2409881
LY 2409881
LY2409881 trihydrochloride
LY2409881 trihydrochloride USP/EP/BP
2-[5-chloro-2-[3-(4-methylpiperazin-1-yl)propylamino]pyrimidin-4-yl]-N-cyclopropyl-1-benzothiophene-4-carboxamide
2-(5-chloro-2-(3-(4-methylpiperazin-1-yl)propylamino)pyrimidin-4-yl)-N-cyclopropylbenzo[b]thiophene-4-carboxamide trihydrochloride
所属类别
生物化工：IκB/IKK 抑制剂物理化学性质
储存条件-20°C储存
溶解度≥59.4 mg/mL in DMSO with ultrasonic; insoluble in EtOH; insoluble in H2O
形态固体
颜色Light yellow to yellow
常见问题列表
生物活性
LY2409881 是一种有效的选择性 IKK2 抑制剂，IC50 为 30 nM，选择性比IKK1和其他常见激酶高10倍多。体外研究
LY2409881 inhibits constitutively activated NF-ƘB, and causes concentration- and time-dependent growth inhibition and apoptosis in diffuse large B-cell lymphoma (DLBCL) cells. In the ovarian cancer cell line SKOV3, LY2409881 demonstrates moderate cytotoxicity. LY2409881 is synergistic with doxorubicin and cyclophosphamide in SUDHL2 cell in inhibiting the cell growth, but not in LY1 cell. In both SUDHL2 and LY1 cells, LY2409881 is synergistic with the histone deacetylase (HDAC) inhibitor romidepsin in inhibiting the cell growth.体内研究
In SCID-beige xenograft mouse model, LY2409881 (50, 100, and 200 mg/kg, i.p.) significantly inhibits the tumor growth.IKK2抑制剂（LY2409881）价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/02/08 | HY-B0788A | IKK2抑制剂（LY2409881） LY2409881 trihydrochloride | 946518-60-1 | 1 mg | 354元 |
| 2025/02/08 | HY-B0788A | IKK2抑制剂（LY2409881） LY2409881 trihydrochloride | 946518-60-1 | 5mg | 800元 |
| 2025/02/08 | HY-B0788A | IKK2抑制剂（LY2409881） LY2409881 trihydrochloride | 946518-60-1 | 10mM * 1mLin DMSO | 1046元 |