94841-17-5

中文名称盐酸螺普利

CAS 94841-17-5

分子式 C22H30N2O5S2.HCl

分子量 503.07

MOL 文件 94841-17-5.mol

更新日期 2023/03/20 15:41:17

94841-17-5 结构式

基本信息物理化学性质常见问题列表

基本信息

中文别名

盐酸螺普利

英文别名

Renpress
Renormax
Sandopril
TI 211-950
Spirapril HCl
Unii-occ25lm897
Spirapril hydrochloride
(8S)-7-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylic Acid Monohydrochloride
1,4-Dithia-7-azaspiro(4.4)nonane-8-carboxylic acid, 7-(2-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)-, monohydrochloride, (8S-(7(R*(R*)),8R*))-

物理化学性质

熔点192-1940C (dec.)

比旋光度D26 -11.2° (c = 0.4 in ethanol)

储存条件-20°C冷冻

常见问题列表

生物活性

Spirapril (SCH 33844) hydrochloride 是一种有效的血管紧张素转换酶 (ACE) 抑制剂，具有降压作用。Spirapril hydrochloride 竞争性地与 ACE 结合，阻止血管紧张素I向血管紧张素 II 的转化。Spirapril hydrochloride 是螺普利拉的一种口服活性前药，可用于高血压、充血性心力衰竭的研究。

靶点

IC50: angiotensin converting enzyme

体内研究

Spirapril (feeding needle; 10 mg/kg; 3 weeks) decreases alcohol intake in TGM123 mice and dose not reduce the alcohol consumption in TLM mice. Spirapril shows a 40.2% reduction in ACE activity in brain membrane from treated-mice. It crosses the blood-brain barrier and suppresses the transgene effect in the experiments.

Animal Model:	TGM123 mice (expressing a rat angiotensinogen transgene) and TLM ( lacking the angiotensinogen gene) mice
Dosage:	10 mg/kg
Administration:	Feeding needle; 10 mg/kg; 3 weeks
Result:	Alter voluntary alcohol consumption in animals. Crossed the blood-brain barrier and may influences alcohol consumption mainly by decreasing central angiotensin II (AII) levels.