| Identification | Back Directory | [Name]
Spirapril hydrochloride | [CAS]
94841-17-5 | [Synonyms]
Renormax
Renpress
Sandopril
TI 211-950
Spirapril HCl
Unii-occ25lm897
Spirapril hydrochloride
(8S)-7-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylic Acid Monohydrochloride
1,4-Dithia-7-azaspiro(4.4)nonane-8-carboxylic acid, 7-(2-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)-, monohydrochloride, (8S-(7(R*(R*)),8R*))- | [Molecular Formula]
C22H30N2O5S2.HCl | [MOL File]
94841-17-5.mol | [Molecular Weight]
503.07 |
| Chemical Properties | Back Directory | [Appearance]
White Solid | [Melting point ]
192-1940C (dec.) | [alpha ]
D26 -11.2° (c = 0.4 in ethanol) | [storage temp. ]
-20°C Freezer | [solubility ]
Very slightly soluble in water, soluble in methanol, slightly soluble in acetonitrile, practically insoluble in methylene chloride. | [form ]
Solid | [color ]
White to Off-White | [Stability:]
Hygroscopic |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Uses]
Angiotensin-converting enzyme (ACE) inhibior. Antihypertensive | [Description]
Spirapril hydrochloride is a new ACE inhibitor introduced in Finland for
the treatment of hypertension. Spirapril is orally active and rapidly absorbed and
converted to the active diacid spiraprilat which produces a reduction in blood pressure
similar to that seen with enalapril and captopril. Spirapril has been reported to be well
tolerated and exhibits an apparently lower incidence of cough compared with other ACE
inhibitors. The elimination of spirapril occurs via both renal and hepatic routes so that
no dosage adjustment is required for patients with renal impairment. In patients with
severe congestive heart failure, spirapril has demonstrated beneficial hemodynamic
effects with a duration of action >24 hours. | [Originator]
Schering-Plough (U.S.A.) | [Brand name]
Renormax (Schering);Renpress. |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Bide Pharmatech Ltd.
|
| Telephone: |
400-1647117 13681763483 |
| Website: |
https://www.bidepharm.com/ |
|