网站主页 >> CAS数据库列表 >> PYRROLIDINE, 2-(4-FLUOROPHENYL)-1-[(4-METHYLPHENYL)SULFONYL]-, (2S)-
PYRROLIDINE, 2-(4-FLUOROPHENYL)-1-[(4-METHYLPHENYL)SULFONYL]-, (2S)-
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- CAS号:
- 298690-60-5
- 英文名:
- Ro 67-7476
- 英文别名:
- Ro 67-7476;RO67-7476;RO-67-7476;(2S)-2-(4-Fluorophenyl)-1-[(4-methylphenyl)sulfonyl]-pyrrolidine;Pyrrolidine, 2-(4-fluorophenyl)-1-[(4-methylphenyl) sulfonyl]-, (2S)-;excitatory postsynaptic potentials,Ro 67-7476,cAMP accumulation,mGluR,neuronal culture,Metabotropic glutamate receptors,Ro 67 7476,inhibit,Ro 677476,traumatic injury,mGluR1,Inhibitor
- 中文名:
- PYRROLIDINE, 2-(4-FLUOROPHENYL)-1-[(4-METHYLPHENYL)SULFONYL]-, (2S)-
- 中文别名:
- 化合物RO 67-7476
- CBNumber:
- CB02561080
- 分子式:
- C17H18FNO2S
- 分子量:
- 319.39
- MOL File:
- 298690-60-5.mol
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PYRROLIDINE, 2-(4-FLUOROPHENYL)-1-[(4-METHYLPHENYL)SULFONYL]-, (2S)-化学性质
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沸点:
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452.9±55.0 °C(Predicted)
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密度:
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1.268±0.06 g/cm3(Predicted)
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储存条件:
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Store at RT
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溶解度:
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DMSO:30.0(Max Conc. mg/mL);93.9(Max Conc. mM)
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酸度系数(pKa):
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-5.53±0.40(Predicted)
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形态:
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Powder
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PYRROLIDINE, 2-(4-FLUOROPHENYL)-1-[(4-METHYLPHENYL)SULFONYL]-, (2S)-性质、用途与生产工艺
Ro 67-7476 是 mGluR1 的一种有效的正变位调节剂，能增强表达 rat mGluR1a 的 HEK293 细胞中谷氨酸诱导的钙释放，EC50为 60.1 nM。Ro 67-7476 是一种有效的 P-ERK1/2 激动剂，可以在外源添加谷氨酸的情况下激活 ERK1/2 磷酸化 (EC50=163.3 nM)。
In the Purkinje cells of rat cerebellar slices, Ro 67-7476 increases the amplitude of mGluR1 excitatory postsynaptic potentials (EPSCs) evoked by 2,3-dihydroxy-6-nitro-7-sulfamoylbenzoquionxaline, picrotoxin, or AP5.
Ro 67-7476 activates ERK1/2 phosphorylation in the absence of exogenously added glutamate (EC
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=163.3 nM). The EC50 value of full P-ERK1/2 activation for Ro 67-7476 are nearly identical to the EC
50
for calcium mobilization potentiation.Ro 67-7476 increases basal cAMP production approximately by 8%. It potentiated threshold responses to glutamate in the cAMP accumulation assay, with an EC
50
value of 17.7 µM.
PYRROLIDINE, 2-(4-FLUOROPHENYL)-1-[(4-METHYLPHENYL)SULFONYL]-, (2S)-
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| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/04/30 | HY-100403 | PYRROLIDINE, 2-(4-FLUOROPHENYL)-1-[(4-METHYLPHENYL)SULFONYL]-, (2S)-
Ro 67-7476 | 298690-60-5 | 2mg | 500元 |
| 2024/04/30 | HY-100403 | PYRROLIDINE, 2-(4-FLUOROPHENYL)-1-[(4-METHYLPHENYL)SULFONYL]-, (2S)-
Ro 67-7476 | 298690-60-5 | 10mM * 1mLin DMSO | 878元 |
PYRROLIDINE, 2-(4-FLUOROPHENYL)-1-[(4-METHYLPHENYL)SULFONYL]-, (2S)-
生产厂家
298690-60-5, PYRROLIDINE, 2-(4-FLUOROPHENYL)-1-[(4-METHYLPHENYL)SULFONYL]-, (2S)- 相关搜索:
- 化合物RO 67-7476
- 298690-60-5
- excitatory postsynaptic potentials,Ro 67-7476,cAMP accumulation,mGluR,neuronal culture,Metabotropic glutamate receptors,Ro 67 7476,inhibit,Ro 677476,traumatic injury,mGluR1,Inhibitor
- RO67-7476;RO-67-7476
- (2S)-2-(4-Fluorophenyl)-1-[(4-methylphenyl)sulfonyl]-pyrrolidine
- Pyrrolidine, 2-(4-fluorophenyl)-1-[(4-methylphenyl) sulfonyl]-, (2S)-
- Ro 67-7476