ChemicalBook >> CAS DataBase List >>Ro 67-7476
Ro 67-7476
- CAS No.
- 298690-60-5
- Chemical Name:
- Ro 67-7476
- Synonyms
- Ro 67-7476;RO67-7476;RO-67-7476;(2S)-2-(4-Fluorophenyl)-1-[(4-methylphenyl)sulfonyl]-pyrrolidine;Pyrrolidine, 2-(4-fluorophenyl)-1-[(4-methylphenyl) sulfonyl]-, (2S)-;excitatory postsynaptic potentials,Ro 67-7476,cAMP accumulation,mGluR,neuronal culture,Metabotropic glutamate receptors,Ro 67 7476,inhibit,Ro 677476,traumatic injury,mGluR1,Inhibitor
- CBNumber:
- CB02561080
- Molecular Formula:
- C17H18FNO2S
- Molecular Weight:
- 319.39
- MDL Number:
- MFCD20270617
- MOL File:
- 298690-60-5.mol
- MSDS File:
- SDS
Last updated:2023-06-30 15:45:59
Ro 67-7476 price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 11993 | Ro 67-7476 | 298690-60-5 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 11993 | Ro 67-7476 | 298690-60-5 | 5mg | $139 | 2024-03-01 | Buy |
| Cayman Chemical | 11993 | Ro 67-7476 | 298690-60-5 | 10mg | $214 | 2024-03-01 | Buy |
| Cayman Chemical | 11993 | Ro 67-7476 | 298690-60-5 | 25mg | $494 | 2024-03-01 | Buy |
| Tocris | 4346 | Ro67-7476 ≥99%(HPLC) | 298690-60-5 | 10 | $212 | 2021-12-16 | Buy |
Ro 67-7476 Chemical Properties,Uses,Production
Description
Ro 67-7476 is a positive allosteric modulator of metabotropic glutamate receptor 1 (mGluR1) that enhances glutamate-induced calcium release in HEK293 cells expressing rat mGluR1a (EC50 = 1.74 μM). It is selective for rat mGluR1 over rat mGluR2, mGluR4, and mGluR8 at a concentration of 10 μM. Ro 67-7476 increases the amplitude of mGluR1 excitatory postsynaptic potentials (EPSCs) evoked by 2,3-dihydroxy-6-nitro-7-sulfamoylbenzoquionxaline, picrotoxin, or AP5 in the Purkinje cells of rat cerebellar slices. It activates ERK1/2 phosphorylation in the absence of exogenously added glutamate (EC50 = 163.3 nM).
Uses
Ro 67-7476 is a positive allosteric metabotropic mGlu1 receptor modulator.
storage
Store at RT
Ro 67-7476 Preparation Products And Raw materials
Raw materials
Preparation Products
Ro 67-7476 Suppliers
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Ro 67-7476
Pyrrolidine, 2-(4-fluorophenyl)-1-[(4-methylphenyl) sulfonyl]-, (2S)-
(2S)-2-(4-Fluorophenyl)-1-[(4-methylphenyl)sulfonyl]-pyrrolidine
RO67-7476;RO-67-7476
excitatory postsynaptic potentials,Ro 67-7476,cAMP accumulation,mGluR,neuronal culture,Metabotropic glutamate receptors,Ro 67 7476,inhibit,Ro 677476,traumatic injury,mGluR1,Inhibitor
298690-60-5