依克立达盐酸盐
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- CAS号:
- 143851-98-3
- 英文名:
- Elacridar HCl
- 英文别名:
- EOS-62093;Elacridar HC1;Elacridar HCl;Elacridar HCl USP/EP/BP;Elacridar (hydrochloride);Elacridar HCl (GF120918A);GF 120918A; GF120918A; GF-120918A;N-(4-(2-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-5-methoxy-9-oxo-9,10-dihy;N-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]-5-methoxy-9-oxo-10H-acridine-4-carboxamide,hydrochloride;N-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-5-methoxy-9-oxo-9,10-dihydroacridine-4-carboxamidehydrochloride
- 中文名:
- 依克立达盐酸盐
- 中文别名:
- 盐酸盐依克立达;依克立达盐酸盐;ELACRIDAR盐酸盐
- CBNumber:
- CB12473818
- 分子式:
- C34H33N3O5.ClH
- 分子量:
- 600.112
- MOL File:
- 143851-98-3.mol
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依克立达盐酸盐化学性质
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熔点:
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>198oC (dec.)
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储存条件:
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Sealed in dry,Room Temperature
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溶解度:
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DMSO (Very Slightly, Heated), Methanol (Very Slightly, Heated)
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形态:
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Solid
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颜色:
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Orange
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稳定性:
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Hygroscopic
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CAS 数据库:
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143851-98-3
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依克立达盐酸盐性质、用途与生产工艺
依克立达盐酸盐的游离碱依克立达是第三代P-蛋白抑制剂， 能够抑制ABC转运蛋白AB-CB1和ABCG2。
一种基于PAMAM的联合携载阿霉素及耐药逆转剂的纳米递送系统的制备方法，包括以下步骤：制作PAMAM靶向给药载体的甲醇溶液；制作盐酸阿霉素的甲醇溶液，并向其中加入三乙胺中和盐酸，使阿霉素游离出来制得阿霉素的甲醇溶液；制作耐药逆转剂的三氯甲烷溶液；边搅拌边将阿霉素的甲醇溶液、耐药逆转剂的三氯甲烷溶液和PAMAM靶向给药载体的甲醇溶液混合并在氮气保护下油浴；去有机溶剂；用蒸馏水溶解；离心后取上层清液。本发明耐药逆转剂依克立达的作用位点是细胞膜上的P糖蛋白，可以使进入细胞的阿霉素量增加，不被泵出。本发明改善耐药逆转剂依克立达水溶性差的缺陷，将耐药逆转剂依克立达包埋于PAMAM中，可以提高其生物利用度。
Elacridar hydrochloride (GF120918A) 是一种有效的 P-糖蛋白 (P-glycoprotein) 和 BCRP 的抑制剂。
依克立达盐酸盐
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| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-50880 | Elacridar hydrochloride | | 5 mg | 895元 |
| 2024/01/25 | HY-50880 | 依克立达盐酸盐
Elacridar hydrochloride | 143851-98-3 | 10mg | 1432元 |
143851-98-3, 依克立达盐酸盐 相关搜索:
- 药靶配体
- 医药原料
- 科研原料
- C34H34ClN3O5
- C34H33N3O5HCl
- ELACRIDAR盐酸盐
- 盐酸盐依克立达
- 依克立达盐酸盐
- 143851-98-3
- Elacridar HCl (GF120918A)
- Elacridar HCl USP/EP/BP
- N-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]-5-methoxy-9-oxo-10H-acridine-4-carboxamide,hydrochloride
- GF 120918A; GF120918A; GF-120918A
- N-[4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-9,10-dihydro-5-methoxy-9-oxo-4-acridinecarboxamide hydrochloride
- EOS-62093
- N-(4-(2-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-5-methoxy-9-oxo-9,10-dihy
- Elacridar HCl
- Elacridar HC1
- N-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-5-methoxy-9-oxo-9,10-dihydroacridine-4-carboxamidehydrochloride
- N-[4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-9,10-dihydro-5-methoxy-9-oxo-4-acridinecarboxamide monohydrochloride
- 4-Acridinecarboxamide, N-[4-[2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-9,10-dihydro-5-methoxy-9-oxo-, hydrochloride (1:1)
- Elacridar (hydrochloride)
- GW 0918
N-[4-[2-(3,4-Dihydro-6,7-diMethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-9,10-dihydro-5-Methoxy-9-oxo-4-acridinecarboxaMide, (HCl salt)
- 1-{2-carbaMoyl-5-[2-(6,7-diMethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl]phenyl}-5-Methoxy-9-oxo-9,10-dihydroacridine-4-carboxylic acid hydrochloride