利普司他丁-1
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- CAS号:
- 950455-15-9
- 英文名:
- Liproxstatin-1
- 英文别名:
- CS-1656;Liproxstatin-1;Liproxstatin-1 USP/EP/BP;LIPROXSTATIN-1;LIPROXSTATIN1;Liproxstatin-1 HCl(free base);N-(3-Chlorobenzyl)-1'H-spiro[piperidine-4,2'-quinoxalin]-3'-amine;N-(3-Chlorobenzyl)-1'H-spiro[piperidine-4,2'-quinoxalin]-3'-amine;N-[(3-chlorophenyl)methyl]spiro[4H-quinoxaline-3,4'-piperidine]-2-amine;N-[(3-chlorophenyl)methyl]-1'H-spiro[piperidine-4,2'-quinoxaline]-3'-amine;N-[(3-chlorophenyl)methyl]-spiro[piperidine-4,2'(1'H)-quinoxalin]-3'-amine
- 中文名:
- 利普司他丁-1
- 中文别名:
- 152063;脂血抑素-1;利普罗他汀-1;利普司他丁-1;LIPROXSTATIN-1游离态和盐酸盐;N-[(3-氯苯基)甲基]-螺[哌啶-4,2'(1'H)-喹喔啉]-3'-胺;N-[(3-氯苯基)甲基]-螺[哌啶-4,2'(1'H)-喹喔啉]-3'-胺
- CBNumber:
- CB12744611
- 分子式:
- C19H21ClN4
- 分子量:
- 340.85
- MOL File:
- 950455-15-9.mol
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利普司他丁-1化学性质
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沸点:
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581.4±50.0 °C(Predicted)
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密度:
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1.32±0.1 g/cm3(Predicted)
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储存条件:
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-20°C
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溶解度:
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Soluble in DMSO (15 mg/ml)
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形态:
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powder
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酸度系数(pKa):
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9.45±0.40(Predicted)
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颜色:
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white to light brown
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稳定性:
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Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 month.
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利普司他丁-1性质、用途与生产工艺
Liproxstatin-1 是一种有效的 ferroptosis 抑制剂。
Liproxstatin-1 is able to inhibit ferroptosis in the low nanomolar range and inhibit the growth of Gpx4
−/−cells with IC50 of 22 nM. Liproxstatin-1 (50 nM) completely prevents lipid peroxidation in Gpx4
−/−cells. Liproxstatin-1 (200 nM) protects against FINs, such as BSO (10 µM), erastin (1 µM) and RSL3 (0.5 µM), in a dose dependent manner, whereas it fails to rescue cell death induced by staurosporine (0.2 µM) and H
2O
2 (200 µM).
Liproxstatin-1 remarkably extends survival compared with the vehicle-treated group, delays ferroptosis in tubular cells, and mitigates tissue injury in ischaemia/reperfusion-induced liver injury.
Liproxstatin-1是一种有效的ferroptosis抑制剂,IC50为22 nM。
Target | Value |
ferroptosis
(Cell-free assay)
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22 nM
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Liproxstatin-1能够在低纳摩尔范围内抑制铁死亡和Gpx4
与溶剂对照组相比,Liproxstatin-1可显著地延长生存期,抑制管状细胞中铁死亡,减轻缺血/再灌注诱发的肝损伤中的组织损伤。
利普司他丁-1
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-12726 | 利普司他丁-1 Liproxstatin-1 | 950455-15-9 | 2mg | 750元 |
2024/08/19 | HY-12726 | 利普司他丁-1 Liproxstatin-1 | 950455-15-9 | 5mg | 1100元 |
950455-15-9, 利普司他丁-1 相关搜索:
- Inhibitors
- 药靶配体
- 小分子
- 小分子抑制剂
- 小分子抑制剂,天然产物
- N-[(3-氯苯基)甲基]-螺[哌啶-4,2'(1'H)-喹喔啉]-3'-胺
- 利普罗他汀-1
- 脂血抑素-1
- 利普司他丁-1
- LIPROXSTATIN-1游离态和盐酸盐
- 152063
- N-[(3-氯苯基)甲基]-螺[哌啶-4,2'(1'H)-喹喔啉]-3'-胺
- 950455-15-9
- N-(3-Chlorobenzyl)-1'H-spiro[piperidine-4,2'-quinoxalin]-3'-amine
- Liproxstatin-1 HCl(free base)
- Spiro[piperidine-4,2'(1'H)-quinoxalin]-3'-amine, N-[(3-chlorophenyl)methyl]-
- N-[(3-chlorophenyl)methyl]-1'H-spiro[piperidine-4,2'-quinoxaline]-3'-amine
- Liproxstatin-1 USP/EP/BP
- N-[(3-chlorophenyl)methyl]spiro[4H-quinoxaline-3,4'-piperidine]-2-amine
- CS-1656
- LIPROXSTATIN-1;LIPROXSTATIN1
- N-(3-Chlorobenzyl)-1'H-spiro[piperidine-4,2'-quinoxalin]-3'-amine
- N-[(3-chlorophenyl)methyl]-spiro[piperidine-4,2'(1'H)-quinoxalin]-3'-amine
- Liproxstatin-1