心菊内酯
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- CAS号:
- 6754-13-8
- 英文名:
- HELENALIN
- 英文别名:
- Helelin;NSC 85236;HELENALIN;CB1492352;HELENALIN(SH);HELENALIN USP/EP/BP;Helenalin
(NSC 85236);a-dimethyl-3-methyleneazuleno[6,5-b]-furan-2,5-dione;(3as-(3aalpha,4alpha,4abeta,7aalpha,8alpha,9aalpha))-ethyl-3-methylene;6alpha,8beta-dihydroxy-4-oxoambrosa-2,11(13)-dien-12-oicacid12,8-lactone
- 中文名:
- 心菊内酯
- 中文别名:
- 海伦娜林;海伦纳林;锦鸡菊素;心菊内酯;心菊内酯/锦鸡菊素;化合物 T15467
- CBNumber:
- CB1492352
- 分子式:
- C15H18O4
- 分子量:
- 262.3
- MOL File:
- 6754-13-8.mol
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心菊内酯化学性质
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熔点:
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167-168°
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比旋光度:
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D25 -102.8° (c = 3.64 in 95% ethanol)
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沸点:
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325.55°C (rough estimate)
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密度:
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1.0772 (rough estimate)
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折射率:
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1.4300 (estimate)
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储存条件:
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-20°
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溶解度:
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Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 10 mg/ml).
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形态:
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White to off-white solid.
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酸度系数(pKa):
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13.29±0.60(Predicted)
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颜色:
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White
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稳定性:
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Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
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LogP:
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0.870
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心菊内酯性质、用途与生产工艺
Helenalin 是一种抗炎的倍半萜内酯。Helenalin 通过直接靶向 p65 选择性抑制转录因子 NF-κB。Helenalin 具有烷基化活性，以 NF-κB 的 p65 亚基中的半胱氨酸巯基为靶点，从而抑制其 DNA 结合。
Helenalin (10 μM; 20-120 minutes) causes complete inhibition of NF-κB DNA binding after 80 minutes.
The anti-inflammatory, anti-carcinogenic phytochemical, Helenalin is a potent inhibitor of periodic Skp2 accumulation, an F-box protein mediating SCF E3 ligase ubiquitylation and degradation of both CKIs during S phase progression.
Western Blot Analysis
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Cell Line:
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Jurkat T cells
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Concentration:
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10 μM
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Incubation Time:
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20-120 minutes
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Result:
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Caused complete inhibition of NF-κB DNA binding after 80 minutes.
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Helenalin (25 mg/kg; i.p.; 6 to 12 hours) administers to immature male ICR mice caused a rapid decrease in hepatic glutathione levels.
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Animal Model:
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Immature male ICR mice
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Dosage:
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25 mg/kg
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Administration:
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i.p.; 6 to 12 hours
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Result:
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Caused a rapid decrease in hepatic glutathione levels.
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心菊内酯
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-119970 | 心菊内酯
Helenalin | 6754-13-8 | 500μg | 3595元 |
| 2024/01/25 | HY-119970 | 心菊内酯
Helenalin | 6754-13-8 | 1mg | 5395元 |
心菊内酯
生产厂家
全球有 64家供应商
心菊内酯国内生产厂家
6754-13-8, 心菊内酯 相关搜索:
- Miscellaneous Natural Products
- 中药对照品
- 标准品
- 分析试剂标准品
- 心菊内酯/锦鸡菊素
- 化合物 T15467
- 海伦娜林
- 海伦纳林
- 锦鸡菊素
- 心菊内酯
- 6754-13-8
- CB1492352
- HELENALIN USP/EP/BP
- (3aS,4S,4aR,7aR,8R,9aR)-4-hydroxy-4a,8-dimethyl-3-methylene-3,3a,4,4a,7a,8,9,9a-octahydroazuleno[6,5-b]furan-2,5-dione
- Azuleno[6,5-b]furan-2,5-dione, 3,3a,4,4a,7a,8,9,9a-octahydro-4-hydroxy-4a,8-dimethyl-3-methylene-, (3aS,4S,4aR,7aR,8R,9aR)-
- Helelin
- NSC 85236
- Helenalin
(NSC 85236)
- [3as]-3,3aalpha,4alpha,4a,7aalpha,8,9,9aalpha-octahydro-4-hydroxy-4abeta,8alph
- azuleno(6,5-b)furan-2,5-dione,3,3a,4,4a,7a,8,9,9a-octahydro-4-hydroxy-4a,8-dim
- ambrosa-2,11(13)-dien-12-oicacid,6alpha,8beta-dihydroxy-4-oxo-,12,8-lactone
- ambrosa-2,11(13)-dien-12-oicacid,6-alpha,8-beta-dihydroxy-4-oxo-,12,8-lacton
- a-dimethyl-3-methyleneazuleno[6,5-b]-furan-2,5-dione
- 6alpha,8beta-dihydroxy-4-oxoambrosa-2,11(13)-dien-12-oicacid12,8-lactone
- HELENALIN
- HELENALIN(SH)
- (3as-(3aalpha,4alpha,4abeta,7aalpha,8alpha,9aalpha))-ethyl-3-methylene