HELENALIN
- CAS No.
- 6754-13-8
- Chemical Name:
- HELENALIN
- Synonyms
- Helelin;NSC 85236;HELENALIN;CB1492352;HELENALIN(SH);HELENALIN USP/EP/BP;Helenalin (NSC 85236);a-dimethyl-3-methyleneazuleno[6,5-b]-furan-2,5-dione;(3as-(3aalpha,4alpha,4abeta,7aalpha,8alpha,9aalpha))-ethyl-3-methylene;6alpha,8beta-dihydroxy-4-oxoambrosa-2,11(13)-dien-12-oicacid12,8-lactone
- CBNumber:
- CB1492352
- Molecular Formula:
- C15H18O4
- Molecular Weight:
- 262.3
- MDL Number:
- MFCD01674580
- MOL File:
- 6754-13-8.mol
- MSDS File:
- SDS
| Melting point | 167-168° |
|---|---|
| alpha | D25 -102.8° (c = 3.64 in 95% ethanol) |
| Boiling point | 325.55°C (rough estimate) |
| Density | 1.0772 (rough estimate) |
| refractive index | 1.4300 (estimate) |
| storage temp. | -20° |
| solubility | Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 10 mg/ml). |
| form | White to off-white solid. |
| pka | 13.29±0.60(Predicted) |
| color | White |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
| LogP | 0.870 |
| FDA UNII | 4GUY9L896T |
SAFETY
Risk and Safety Statements
| RIDADR | 2811 |
|---|---|
| HazardClass | 6.1(b) |
| PackingGroup | III |
| Toxicity | LD50 in mice, rats (mg/kg): 150, 125 orally (Witzel) |
HELENALIN price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 374000 | Helenalin, A. chamissonis ssp. foliosa | 6754-13-8 | 500μG | $617 | 2024-03-01 | Buy |
| Cayman Chemical | 17050 | Helenalin ≥98% | 6754-13-8 | 1mg | $504 | 2024-03-01 | Buy |
| TRC | H230000 | Helenalin | 6754-13-8 | 0.25mg | $160 | 2021-12-16 | Buy |
| ChemScene | CS-0078850 | Helenalin 98.29% | 6754-13-8 | 500ug | $270 | 2021-12-16 | Buy |
| Adipogen Life Sciences | AG-CN2-0435-M001 | Helenalin ≥96%(HPLC) | 6754-13-8 | 1mg | $390 | 2021-12-16 | Buy |
HELENALIN Chemical Properties,Uses,Production
Description
Helenalin (6754-13-8) is a novel sesquiterpene lactone which inhibits NFκB1?and displays potent anti-inflammatory activity2. It suppresses essential immune functions of activated CD4+ T cells by multiple mechanisms.3 Helenalin also inhibits telomerase and this activity may be partially responsible for its anti-tumor effects.4
Uses
Helenalin is a highly toxic compound, with hepatic and lymphatic tissues particularly vulnerable to its effects. It is believed to be responsible for the toxicity and skin irritation associated with Arnica. If enough of the plant is ingested, the helenalin produces severe gastroenteritis and internal bleeding of the digestive tract.
Definition
ChEBI: Helenalin is a sesquiterpene lactone that is 3,3a,4,4a,7a,8,9,9a-octahydroazuleno[6,5-b]furan-2,5-dione substituted by a hydroxy group at position 4, methyl groups at positions 4a and 8 and a methylidene group at position 3 (the 3aS,4S,4aR,7aR,8R,9aR stereoisomer). It has a role as an anti-inflammatory agent, an antineoplastic agent, a plant metabolite and a metabolite. It is a gamma-lactone, a cyclic ketone, an organic heterotricyclic compound, a sesquiterpene lactone and a secondary alcohol.
storage
+4°C
References
1) Lyss?et al. (1998),?The anti-inflammatory sesquiterpene lactone helenalin inhibits the transcription factor NF-kappaB by directly targeting p65; J. Biol. Chem.,?273?33508 2) Lyss?et al. (1997),?Helenalin, an anti-inflammatory sesquiterpene lactone from Arnica, selectively inhibits transcription factor NF-κB; Biol. Chem.,?278?951 3) Berges?et al. (2009),?Helenalin suppresses essential immune functions of activated CD4+ T cells by multiple mechanisms; Mol. Immunol.,?46?2892 4) Huang?et al. (2005),?Potent inhibition of human telomerase by helenalin; Cancer Lett.,?227?169
HELENALIN Preparation Products And Raw materials
Raw materials
Preparation Products
HELENALIN Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 7933 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23556 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29118 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33349 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| ChemStrong Scientific Co.,Ltd | 0755-0755-66853366 13670046396 | sales@chem-strong.com | China | 17982 | 56 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7892 | 56 |
