ChemicalBook
English   Japanese   Germany   Korea

网站主页 >> CAS数据库列表 >> 1-(5-hydroxyhexyl)-3,7-dimethyl-purine-2,6-dione

1-(5-hydroxyhexyl)-3,7-dimethyl-purine-2,6-dione

生物活性 靶点 体外研究 体内研究 1-(5-hydroxyhexyl)-3,7-dimethyl-purine-2,6-dione 试剂级价格
1-(5-hydroxyhexyl)-3,7-dimethyl-purine-2,6-dione, 100324-81-0, 结构式
1-(5-hydroxyhexyl)-3,7-dimethyl-purine-2,6-dione
CAS号:
100324-81-0
英文名:
1-(5-hydroxyhexyl)-3,7-dimethyl-purine-2,6-dione
英文别名:
ProTec;CT 1501R;Lisophylline;(R)-Lisofylline;1-(5-hydroxyhexyl)-3,7-dimethyl-purine-2,6-dione;3,7-Dihydro-1-[(5R)-5-hydroxyhexyl]-3,7-diMethyl-;1-[(5R)-5-hydroxyhexyl]-3,7-dimethylpurine-2,6-dione;3,7-Dihydro-1-[(5R)-5-hydroxyhexyl]-3,7-dimethyl-1H-purine-2,6-dione;1H-Purine-2,6-dione, 3,7-dihydro-1-[(5R)-5-hydroxyhexyl]-3,7-dimethyl-;Pentoxifylline,Inhibitor,STAT,anti-inflammatory,inhibit,STAT4,(R)-Lisophylline,lysophosphatidic,(R)Lisofylline,acid,IL-12,IFN-γ,diabetes,immunomodulator,(R) Lisofylline,(R)-Lisofylline,acyltransferase,LPS,metabolite
中文名:
1-(5-hydroxyhexyl)-3,7-dimethyl-purine-2,6-dione
中文别名:
化合物(R)-LISOFYLLINE;1-(5-羟基己基)-3,7-二甲基嘌呤-2,6-二酮;(R)-1-(5-羟基己基)-3,7-二甲基-1H-嘌呤-2,6(3H,7H)-二酮
CBNumber:
CB21454169
分子式:
C13H20N4O3
分子量:
280.32
MOL File:
100324-81-0.mol

1-(5-hydroxyhexyl)-3,7-dimethyl-purine-2,6-dione化学性质

熔点:
105-107°C
比旋光度:
D20 -5.6° (c = 6.7 in ethanol)
沸点:
511.2±56.0 °C(Predicted)
密度:
1.32±0.1 g/cm3(Predicted)
储存条件:
Hygroscopic, -20°C Freezer, Under Inert Atmosphere
溶解度:
Chloroform, Methanol
形态:
Solid
酸度系数(pKa):
15.22±0.20(Predicted)
颜色:
White to Off-White
稳定性:
Hygroscopic
安全信息

1-(5-hydroxyhexyl)-3,7-dimethyl-purine-2,6-dione性质、用途与生产工艺

生物活性

(R)-Lisofylline ((R)-Lisophylline) 是一种 Pentoxifylline 代谢产物的 (R)-型对映体，具有抗炎特性。(R)-Lisofylline 是一种溶血磷脂酸酰基转移酶 (lysophosphatidic acid acyltransferase ) 抑制剂，IC50 为 0.6 µM，可中断 IL-12 信号介导的 STAT4 激活。(R)-Lisofylline 可用于 1 型糖尿病，自身免疫性疾病的研究。

靶点

IC50: 0.6 µM (Lysophosphatidic acid acyltransferase)
STAT4

体外研究

(R)-Lisofylline blocks IL-12-driven Th1 differentiation and T cell proliferation in vitro, yet has no effect on IL-12 secretion from APCs ex vivo or in vitro.

体内研究

(R)-Lisofylline reduces the impairment of insulin secretion induced by IL-1β in cultured rat islet cells, suppresses IFN-γ production, the onset of diabetes, and macrophage infiltration into islets from NOD mice, as well as Lisofylline improves insulin response and lowers glucose levels in Streptozotocin-treated rats after the oral glucose tolerance test.
(R)-Lisofylline prevents β cell dysfunction in NOD mice by inhibition of STAT4 phosphorylation which interrupts IL-12 signaling. (R)-Lisofylline ameliorates experimental allergic encephalomyelitis in mice.
(R)-Lisofylline also improves survival in mice injected with a lethal dose of LPS and ameliorates sepsis-induced lung injury in minipigs. In rats given IL-1 intratracheally (R)-Lisofylline pretreatment reduces lung leak but does not decrease neutrophil accumulation in lungs.
(R)-Lisofylline also suppresses release of TNF-α in vivo in mice and ex vivo in human blood stimulated with endotoxin derived from Salmonella or Escherichia coli .

1-(5-hydroxyhexyl)-3,7-dimethyl-purine-2,6-dione 上下游产品信息

上游原料

下游产品

1-(5-hydroxyhexyl)-3,7-dimethyl-purine-2,6-dione 试剂级价格

更新日期产品编号产品名称CAS编号包装价格
2024/04/30HY-109854A(R)-Lisofylline1 mg980元
2024/04/30HY-109854A1-(5-hydroxyhexyl)-3,7-dimethyl-purine-2,6-dione
(R)-Lisofylline		100324-81-05mg1950元

1-(5-hydroxyhexyl)-3,7-dimethyl-purine-2,6-dione 生产厂家

全球有 47家供应商   1-(5-hydroxyhexyl)-3,7-dimethyl-purine-2,6-dione国内生产厂家
供应商联系电话电子邮件国家产品数优势度
北京百灵威科技有限公司 010-82848833 400-666-7788 jkinfo@jkchemical.com 中国 96815 76
LGM Pharma 1-(800)-881-8210 inquiries@lgmpharma.com 美国 2127 70
凯试（上海）科技有限公司 021-50135380 shchemsky@sina.com 中国 32344 50
上海遐瑞医药科技有限公司 +86 21 61551611 中国 9901 58
Clearsynth Labs Limited +91-22-26355700 info@clearsynth.com 印度 9685 58
上海陶素生化科技有限公司 021-33632979 info@tsbiochem.com 中国 8073 58
深圳聚合生化科技有限公司 +86-400-002-6226 13028896684 sales@rrkchem.com 中国 55827 58
ChemeGen 中国 18818260767 sales@chemegen.com 中国 11289 58
台州南峰药物研究所 12345678910 nanfengdrug@163.com 中国 15323 58
安耐吉化学&3A（安徽泽升科技有限公司） 021-58432009 400-005-6266 marketing1@energy-chemical.com 中国 44894 58
MedBio脉铂医药 021-69568360 18916172912 order@med-bio.cn 中国 8141 58
梯希爱（上海）化工贸易有限公司 021-61109150 sales@tcisct.com 中国 31163 58
南通全益生物科技有限公司 18051384581 sales@chemhifuture.com 中国 2996 58
天津普西唐生物医药科技有限公司 010-60605840 15801484223 psaitong@jm-bio.com 中国 29834 58
苏州致信生物科技有限公司 0512-65118909 15162312715 sales@szzxbio.com 中国 2999 58
上海立崎生物医学研究中心 18014399201 sales@chemlab-tachizaki.com 中国 2488 58
上海一飞生物科技有限公司 021-65675885 18964387627 customer_service@efebio.com 中国 8740 58
江苏艾康生物医药研发有限公司 025-66113011 18112977050 cb5@aikonchem.com 中国 10529 58
南京世洲生物科技有限公司 025-85560043 15850508050 cindy.huang@synzest.com 中国 12007 58
上海阿拉丁生化科技股份有限公司 +86-18521732826 market@aladdin-e.com 中国 48570 58
銳迪國際科技有限公司 18988968278 sales@ubiochem.com 中国 9146 58
Aladdin Scientific Corporation +1-833-552-7181 sales@aladdinsci.com 美国 57511 58
Nantong HI-FUTURE Biology Co., Ltd. +undefined18051384581 sales@chemhifuture.com 中国 3136 58
ApexBio技术 sales@apexbt.com 美国 6254 58
 

100324-81-0, 1-(5-hydroxyhexyl)-3,7-dimethyl-purine-2,6-dione 相关搜索:

二甲苯 二甲基硫 二甲基砜 4-羟基香豆素 8-羟基喹啉 利索茶碱 1-正-己基可可碱 托巴茶碱
  • Pharmaceuticals
  • Metabolites & Impurities
  • Intermediates & Fine Chemicals
  • Various Metabolites and Impurities
  • Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
  • 合成有机化合物配体
  • (R)-1-(5-羟基己基)-3,7-二甲基-1H-嘌呤-2,6(3H,7H)-二酮
  • 化合物(R)-LISOFYLLINE
  • 1-(5-羟基己基)-3,7-二甲基嘌呤-2,6-二酮
  • 100324-81-0
  • Pentoxifylline,Inhibitor,STAT,anti-inflammatory,inhibit,STAT4,(R)-Lisophylline,lysophosphatidic,(R)Lisofylline,acid,IL-12,IFN-γ,diabetes,immunomodulator,(R) Lisofylline,(R)-Lisofylline,acyltransferase,LPS,metabolite
  • 1-[(5R)-5-hydroxyhexyl]-3,7-dimethylpurine-2,6-dione
  • 1H-Purine-2,6-dione, 3,7-dihydro-1-[(5R)-5-hydroxyhexyl]-3,7-dimethyl-
  • 3,7-Dihydro-1-[(5R)-5-hydroxyhexyl]-3,7-diMethyl-
  • (R)-Lisofylline
  • ProTec
  • Lisophylline
  • CT 1501R
  • 3,7-Dihydro-1-[(5R)-5-hydroxyhexyl]-3,7-dimethyl-1H-purine-2,6-dione
  • 1-(5-hydroxyhexyl)-3,7-dimethyl-purine-2,6-dione
Copyright 2016 © ChemicalBook. All rights reserved