LP-211
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- CAS号:
- 1052147-86-0
- 英文名:
- N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide
- 英文别名:
- LP21;LP-211;LP-211 >=98% (HPLC);LP-211; LP 211; LP211;1052147-86-0;N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide;1-Piperazinehexanamide, 4-[1,1'-biphenyl]-2-yl-N-[(4-cyanophenyl)methyl]-;LP 211,Inhibitor,5-HT Receptor,Serotonin Receptor,LP-211,5-hydroxytryptamine Receptor,LP211,inhibit
- 中文名:
- LP-211
- 中文别名:
- 化合物LP-211
- CBNumber:
- CB23385434
- 分子式:
- C30H34N4O
- 分子量:
- 466.62
- MOL File:
- 1052147-86-0.mol
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LP-211化学性质
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沸点:
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714.8±60.0 °C(Predicted)
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密度:
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1.17±0.1 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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DMSO:100.0(Max Conc. mg/mL);214.3(Max Conc. mM)
Ethanol:50.0(Max Conc. mg/mL);107.15(Max Conc. mM)-
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酸度系数(pKa):
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15.39±0.46(Predicted)
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形态:
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solid
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颜色:
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clear white to light brown
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LP-211性质、用途与生产工艺
LP-211 是一种选择性的，可透过血脑屏障的 5-HT7 受体激动剂，Ki 值为 0.58 nM，选择性高于 5-HT1A 受体 (Ki，188 nM) 和 D2 受体 (Ki，142 nM)。
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5-HT
7
Receptor
0.58 nM (Ki)
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5-HT
1A
Receptor
188 nM (Ki)
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D
2
Receptor
142 nM (Ki)
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LP-211 is a selective 5-HT
7
receptor agonist, with a K
i
of 0.58 nM, 324- and 245-fold selectivity over 5-HT
1A
receptor (K
i
, 188 nM) and D
2
receptor (K
i
, 142 nM). LP-211 shows agonist properties with an EC
50
of 0.6 μM.
LP-211 (10 mg/kg, i.p.) rapidly reaches the systemic circulation in the mouse, with mean C
max
of 0.76 ± 0.32 μg/mL at 30 min. LP-211 (0.003-0.3 mg/kg, i.p.) significantly increases the micturition volume in a dose-dependent manner, and causes significant increases in voiding efficiency in spinal cord-injured (SCI) rats, and such effects can be completely reversed by SB-269970. LP-211 (0.25 and 0.50 mg/kg i.p.) improves consolidation of chamber-shape memory in rats, resulting in significant novelty-induced hyperactivity and recognition.
LP-211
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-111455 | LP-211
LP-211 | 1052147-86-0 | 5mg | 800元 |
| 2024/01/25 | HY-111455 | LP-211
LP-211 | 1052147-86-0 | 10mM * 1mLin DMSO | 880元 |
1052147-86-0, LP-211 相关搜索:
- API
- 化合物LP-211
- 1052147-86-0
- 1-Piperazinehexanamide, 4-[1,1'-biphenyl]-2-yl-N-[(4-cyanophenyl)methyl]-
- LP 211,Inhibitor,5-HT Receptor,Serotonin Receptor,LP-211,5-hydroxytryptamine Receptor,LP211,inhibit
- LP-211 >=98% (HPLC)
- LP21
- LP-211; LP 211; LP211;1052147-86-0
- N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide
- LP-211