化合物FTBMT
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- CAS号:
- 1358575-02-6
- 英文名:
- FTBMT
- 英文别名:
- FTBMT;TP-024;FTBMT >=98% (HPLC);inhibit,FTBMT,Inhibitor;4-(3-{[3-fluoro-5-(trifluoromethyl)phenyl]methyl}-5
-methyl-1H-1,2,4-triazol-1-yl)-2-methylbenzamide;Benzamide, 4-[3-[[3-fluoro-5-(trifluoromethyl)phenyl]methyl]-5-methyl-1H-1,2,4-triazol-1-yl]-2-methyl-
- 中文名:
- 化合物FTBMT
- 中文别名:
- 化合物FTBMT
- CBNumber:
- CB24662565
- 分子式:
- C19H16F4N4O
- 分子量:
- 392.35
- MOL File:
- 1358575-02-6.mol
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化合物FTBMT化学性质
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储存条件:
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Store at -20°C
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溶解度:
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DMSO:69.62(Max Conc. mg/mL);177.44(Max Conc. mM)
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化合物FTBMT性质、用途与生产工艺
FTBMT 是选择性的 GPR52 激动剂， EC50 为 75 nM。FTBMT 有抗精神病和促进认知活性。
FTBMT (0.1-10 μM) increases intracellular cAMP levels in CHO cells expressing human, mouse, or rat GPR52, with pEC
50
s of 7.03, 6.85, and 6.87, respectively.
Cell Viability Assay
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Cell Line:
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CHO cells (expressing GPR52 receptors) cAMP assay
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Concentration:
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0.1-10 μM
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Incubation Time:
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30 minutes
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Result:
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FTBMT activated cAMP signaling in vitro
[1]
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FTBMT (30 mg/kg, 90 minutes) exhibits antipsychotic-like activity without causing catalepsy in mice.
FTBMT (3 or 10 mg/kg, 48 hours) improves recognition and spatial working memory in rats.
FTBMT (3, 10, 30 mg/kg, 2 hours) stimulates neuronal activity in brain regions related to cognition.
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Animal Model:
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Male Long-Evans rats (9 weeks old)
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Dosage:
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10 mg/kg
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Administration:
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Oral, 1 hour before memory test
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Result:
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A 1-hour pretreatment with FTBMT (10 mg/kg, p.o.) significantly decreases the number of memory errors induced by MK-801
[2]
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Animal Model:
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Male ICR mice (7 to 8 weeks old)
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Dosage:
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3–30 mg/kg
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Administration:
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Oral, 60 minutes before s.c. administration of MK-801
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Result:
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FTBMT increases phospho-DARPP32 levels in the NAc slices
[2]
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化合物FTBMT
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-101787 | 化合物FTBMT
FTBMT | 1358575-02-6 | 5mg | 1100元 |
| 2024/01/25 | HY-101787 | 化合物FTBMT
FTBMT | 1358575-02-6 | 10 mM * 1 mLin DMSO | 1210元 |
1358575-02-6, 化合物FTBMT 相关搜索:
- 化合物FTBMT
- 1358575-02-6
- TP-024
- inhibit,FTBMT,Inhibitor
- 4-(3-{[3-fluoro-5-(trifluoromethyl)phenyl]methyl}-5
-methyl-1H-1,2,4-triazol-1-yl)-2-methylbenzamide
- FTBMT >=98% (HPLC)
- Benzamide, 4-[3-[[3-fluoro-5-(trifluoromethyl)phenyl]methyl]-5-methyl-1H-1,2,4-triazol-1-yl]-2-methyl-
- FTBMT