西他苯
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- CAS号:
- 55986-43-1
- 英文名:
- CETABEN
- 英文别名:
- CETABEN;Peroxisome Proliferator, Cetaben;Benzoic acid, 4-(hexadecylamino)-;HEXADECYLAMINO-P-AMINO BENZOIC ACID;proliferator,peroxisome,cholesterol,exceptional,triglycerides,Inhibitor,Cetaben,inhibit,non-fibrate,hypolipidemic,PPARα,drug
- 中文名:
- 西他苯
- 中文别名:
- 西他苯
- CBNumber:
- CB2752657
- 分子式:
- C23H39NO2
- 分子量:
- 361.56
- MOL File:
- 55986-43-1.mol
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西他苯化学性质
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沸点:
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503.4±33.0 °C(Predicted)
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密度:
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0.979±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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≤1mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide
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形态:
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crystalline solid
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酸度系数(pKa):
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4.76±0.10(Predicted)
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西他苯性质、用途与生产工艺
Cetaben 是一种不依赖 PPARα 的过氧化物酶体增殖物。Cetaben 是一种非纤维化降血脂药，可有效降低胆固醇和甘油三酸酯的浓度。
Cetaben (10 µM; 24 hours) induces severe micromorphological and ultrastructural changes in HepG2 and MH1C1 cells. After treatment with 100 µM cetaben, cells contained several Golgi regions, most of them disintegrated into vesicles.
Cetaben-treated (10 µM; 24 hours) cells were characterized by a striking heterogeneity of the peroxisomal population with the occurrence of dumbbell-shaped and cup-shaped peroxisomal profiles in MH1C1cells.
Cetaben reveales a significant rise in the activities of peroxisomal enzymes in both the liver and kidney at doses of 50-100 mg/kg body over 10 days, but the maximal effect is observed at 250 mg/kg.
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Animal Model:
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Male Wistar rats
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Dosage:
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10,25,50,100,250 and 500 mg/kg
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Administration:
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Gavage; 10 day
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Result:
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Revealed a significant rise in the activities of peroxisomal enzymes in both the liver and kidney at doses of 50-100 mg/kg body over 10 days, but the maximal effect was observed at 250 mg/kg.
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西他苯
上下游产品信息
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下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/01/25 | HY-119964 | 西他苯
Cetaben | 55986-43-1 | 5mg | 500元 |
| 2024/01/25 | HY-119964 | 西他苯
Cetaben | 55986-43-1 | 10mM * 1mLin DMSO | 550元 |
55986-43-1, 西他苯 相关搜索:
- 药靶配体
- 西他苯
- 55986-43-1
- proliferator,peroxisome,cholesterol,exceptional,triglycerides,Inhibitor,Cetaben,inhibit,non-fibrate,hypolipidemic,PPARα,drug
- Benzoic acid, 4-(hexadecylamino)-
- Peroxisome Proliferator, Cetaben
- HEXADECYLAMINO-P-AMINO BENZOIC ACID
- CETABEN