尼普拉嗪
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- CAS号:
- 27367-90-4
- 英文名:
- Niaprazine
- 英文别名:
- Nopron;1709 CERM;Niaprazine;N-(4-(4-(4-FLUOROPHENYL)PIPERAZIN-1-YL)BUTAN-2-YL)NICOTINAMIDE;N-[3-[4-(p-Fluorophenyl)-1-piperazinyl]-1-methylpropyl]nicotinamide;N-[3-[4-(4-Fluorophenyl)-1-piperazinyl]-1-methylpropyl]nicotinamide;N-[3-[4-(4-Fluorophenyl)-1-piperazinyl]-1-methylpropyl]-3-pyridinecarboxamide;3-Pyridinecarboxamide, N-[3-[4-(4-fluorophenyl)-1-piperazinyl]-1-methylpropyl]-;5-HIAA,disorders,sleep,autistic,Histamine Receptor,inhibit,5-HT2,sedative,Inhibitor,Niaprazine,H1-receptor
- 中文名:
- 尼普拉嗪
- 中文别名:
- 尼普拉嗪;N-(4-(4-(4-氟苯基)哌嗪-1-基)丁-2-基)烟酰胺
- CBNumber:
- CB2875198
- 分子式:
- C20H25FN4O
- 分子量:
- 356.4371032
- MOL File:
- 27367-90-4.mol
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尼普拉嗪化学性质
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熔点:
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131℃
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密度:
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1.165
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 100 mg/mL (280.55 mM)
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尼普拉嗪性质、用途与生产工艺
Niaprazine 是一种具有强效镇静作用的组胺 H1 受体 (histamine H1-receptor) 拮抗剂。Niaprazine 具有抗组胺和抗血清素活性，并可用于睡眠障碍的研究。
Niaprazine exhibits a low affinity for the vesicular monoamine transporter and for D2, α2, β, H1 and mAch receptors. Niaprazine, particularly the (+)stereoisomer, has a higher affinity for α1 (Ki = 77 nM) and 5-HT2 (Ki = 25 nM) binding sites, but is poorly recognized by 5-HT1A and 5-HT1B binding sites.
Niaprazine (60 mg/kg; i.p.; once) treatment increases rat brain 5-hydroxyindole acetic acid (5-HIAA) concentrations 30 min after treatment, and reduced them at 3-8 hr after treatment. Niaprazine also produces a short-lasting depletion of rat brain noradrenaline (NA) and dopamine (DA).
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Animal Model:
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Male Sprague-Dawley rats (150-200 g)
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Dosage:
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60 mg/kg
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Administration:
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Intraperitoneal injection; once
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Result:
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Increased rat brain 5-hydroxyindole acetic acid (5-HIAA) concentrations 30 min after treatment, and reduced them at 3-8 hr after treatment.
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尼普拉嗪
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/04/30 | HY-105542 | 尼普拉嗪
Niaprazine | 27367-90-4 | 5mg | 500元 |
| 2024/04/30 | HY-105542 | Niaprazine | | 10 mM * 1 mLin DMSO | 550元 |
27367-90-4, 尼普拉嗪 相关搜索:
- C20H25FN4O
- N-(4-(4-(4-氟苯基)哌嗪-1-基)丁-2-基)烟酰胺
- 尼普拉嗪
- 27367-90-4
- 5-HIAA,disorders,sleep,autistic,Histamine Receptor,inhibit,5-HT2,sedative,Inhibitor,Niaprazine,H1-receptor
- 3-Pyridinecarboxamide, N-[3-[4-(4-fluorophenyl)-1-piperazinyl]-1-methylpropyl]-
- N-(4-(4-(4-FLUOROPHENYL)PIPERAZIN-1-YL)BUTAN-2-YL)NICOTINAMIDE
- Nopron
- N-[3-[4-(4-Fluorophenyl)-1-piperazinyl]-1-methylpropyl]-3-pyridinecarboxamide
- N-[3-[4-(p-Fluorophenyl)-1-piperazinyl]-1-methylpropyl]nicotinamide
- N-[3-[4-(4-Fluorophenyl)-1-piperazinyl]-1-methylpropyl]nicotinamide
- 1709 CERM
- Niaprazine