6-(4-氟苯基)-5-(4-吡啶基)-2,3-二氢咪唑并[2,1-B]-噻唑
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- CAS号:
- 72873-74-6
- 英文名:
- 6-(4-FLUOROPHENYL)-2,3-DIHYDRO-5-(4-PYRIDINYL)IMIDAZO[2,1-B]THIAZOLE DIHYDROCHLORIDE
- 英文别名:
- CS-1711;SKF-86002;SKF 86002;SKF86002;SKF 86002 DIHYDROCHLORIDE;SKF-86002 - CAS 72873-74-6 - Calbiochem;6-(4-fluorophenyl)-5-(pyridin-4-yl)-2,3-dihydroiMidazo[2,1-b]thi;5-(4-Pyridyl)-6-(4-fluorophenyl)-2,3-dihydroimidazo[2,1-b]thiazole;6-(4-FLUOROPHENYL)-2,3-DIHYDRO-5-(4-PYRIDYL)IMIDAZO[2,1-B]THIAZOLE;6-(4-FLUOROPHENYL)-2,3-DIHYDRO-5-(4-PRIDYL)IMIDAZO-[2,1,B]-THAIZOLE;6-(4-FLUOROPHENYL)-5-(4-PYRIDYL)-2,3-DIHYDROIMIDAZO[2,1-B]-THIAZOLE
- 中文名:
- 6-(4-氟苯基)-5-(4-吡啶基)-2,3-二氢咪唑并[2,1-B]-噻唑
- 中文别名:
- 6-(4-氟苯基)-5-(4-吡啶基)-2,3-二氢咪唑并[2,1-B]-噻唑
- CBNumber:
- CB3725388
- 分子式:
- C16H12FN3S
- 分子量:
- 297.35
- MOL File:
- 72873-74-6.mol
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6-(4-氟苯基)-5-(4-吡啶基)-2,3-二氢咪唑并[2,1-B]-噻唑化学性质
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熔点:
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189-190 °C(lit.)
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沸点:
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476.1±55.0 °C(Predicted)
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密度:
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1.39±0.1 g/cm3(Predicted)
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储存条件:
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Keep in dark place,Sealed in dry,2-8°C
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溶解度:
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DMSO: 9 mg/mL, soluble
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形态:
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solid
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酸度系数(pKa):
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4.36±0.10(Predicted)
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颜色:
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off-white
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InChIKey:
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YOELZIQOLWZLQC-UHFFFAOYSA-N
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6-(4-氟苯基)-5-(4-吡啶基)-2,3-二氢咪唑并[2,1-B]-噻唑性质、用途与生产工艺
SKF-86002 是一种具有口服活性的 p38 MAPK 抑制剂,具有抗炎、抗关节炎和镇痛活性。SKF-86002 能抑制脂氧合酶和环氧合酶介导的花生四烯酸代谢。
SKF-86002 (10 μM; 1 hour) inhibits apoptosis induced by stress stimulation with UV irradiation (UV).
SKF-86002 does not inhibit UV-induced apoptosis in undifferentiated HL-60 cells.
SKF-86002 (10 μM; 72 hours) prevent IL-4-induced monocyte or U937 cell CD23 surface expression and protein formation with no effect on CD23 mRNA levels.
Western Blot Analysis
Cell Line:
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U937 cells
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Concentration:
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10 μM
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Incubation Time:
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72 hours
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Result:
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Significantly reduced CD23 levels on IL-4-treated U937 cells.
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SKF-86002 (10-90 mg/kg; p.o.; daily; for 22 days) has antiarthritic activity.
Animal Model:
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Lewis rats, with adjuvant-induced arthritis (AA)
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Dosage:
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10 mg/kg, 30 mg/kg, 90 mg/kg
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Administration:
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Oral administration, daily, for 22 days
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Result:
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Significantly decreased hindleg volumes after injection of adjuvant.
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6-(4-氟苯基)-5-(4-吡啶基)-2,3-二氢咪唑并[2,1-B]-噻唑
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-12511 | 6-(4-氟苯基)-5-(4-吡啶基)-2,3-二氢咪唑并[2,1-B]-噻唑 SKF-86002 | 72873-74-6 | 2mg | 400元 |
2024/08/19 | HY-12511 | 6-(4-氟苯基)-5-(4-吡啶基)-2,3-二氢咪唑并[2,1-B]-噻唑 SKF-86002 | 72873-74-6 | 5 mg | 810元 |
6-(4-氟苯基)-5-(4-吡啶基)-2,3-二氢咪唑并[2,1-B]-噻唑
生产厂家
72873-74-6, 6-(4-氟苯基)-5-(4-吡啶基)-2,3-二氢咪唑并[2,1-B]-噻唑 相关搜索:
- Protein Kinase
- Inhibitors
- 生物试剂
- 小分子抑制剂,天然产物
- 小分子抑制剂
- 抑制剂
- BioChemical
- Cell Signaling and Neuroscience
- Cell Biology
- Serine/Threonine Kinase Inhibitors
- Kinase/Phosphatase Biology
- p38 Mitogen-Activated protein kinase (p38MAPK)
- C16H12FN3S2HCl
- C16H12N3FS
- 6-(4-氟苯基)-5-(4-吡啶基)-2,3-二氢咪唑并[2,1-B]-噻唑
- 72873-74-6
- Imidazo[2,1-b]thiazole, 6-(4-fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)-
- SKF-86002 - CAS 72873-74-6 - Calbiochem
- CS-1711
- SKF 86002;SKF86002
- 6-(4-fluorophenyl)-5-(pyridin-4-yl)-2,3-dihydroimidazo[2,1-b]thiazole
- 6-(4-fluorophenyl)-5-(pyridin-4-yl)-2,3-dihydroiMidazo[2,1-b]thiazole dihydrochloride
- 6-(4-fluorophenyl)-5-(pyridin-4-yl)-2,3-dihydroiMidazo[2,1-b]thi
- 5-(4-Pyridyl)-6-(4-fluorophenyl)-2,3-dihydroimidazo[2,1-b]thiazole
- 4-(4-Pyridyl)-5-(4-fluorophenyl)-2,3-dihydro-1-thia-3a,6-diazapentalene
- 6-(4-fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)imidazo(2,1-b)thiazole
- SKF 86002 DIHYDROCHLORIDE
- SKF-86002
- 6-(4-FLUOROPHENYL)-2,3-DIHYDRO-5-(4-PYRIDYL)IMIDAZO[2,1-B]THIAZOLE
- 6-(4-FLUOROPHENYL)-2,3-DIHYDRO-5-(4-PYRIDINYL)IMIDAZO[2,1-B]THIAZOLE DIHYDROCHLORIDE
- 6-(4-FLUOROPHENYL)-2,3-DIHYDRO-5-(4-PRIDYL)IMIDAZO-[2,1,B]-THAIZOLE
- 6-(4-FLUOROPHENYL)-5-(4-PYRIDYL)-2,3-DIHYDROIMIDAZO[2,1-B]-THIAZOLE