硝呋替莫
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- CAS号:
- 23256-30-6
- 英文名:
- nifurtimox
- 英文别名:
- Lampit;BAY-2502;NIFURIMOX;Bayer-2502;Bayer 2502;Aids007325;nifurtimox;BAY-A-2502;Aids-007325;nifurtimox USP/EP/BP
- 中文名:
- 硝呋替莫
- 中文别名:
- 硝呋莫司;硝呋替莫;NIFURTIMOX [4-氨基-3-甲基四氢-1,4-噻嗪-1,1-二氧化物];3-甲基-4-(((5-硝基呋喃-2-基)亚甲基)氨基)硫代吗啉 1,1-二氧化物
- CBNumber:
- CB3903922
- 分子式:
- C10H13N3O5S
- 分子量:
- 287.29
- MOL File:
- 23256-30-6.mol
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硝呋替莫化学性质
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熔点:
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177-183°C
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沸点:
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550.3±50.0 °C(Predicted)
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密度:
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1.4716 (rough estimate)
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折射率:
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1.6390 (estimate)
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储存条件:
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room temp
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溶解度:
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DMSO: ≥13mg/mL
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酸度系数(pKa):
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-1.01±0.40(Predicted)
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形态:
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powder
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颜色:
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yellow to orange
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水溶解性:
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33g/L(temperature not stated)
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BCS Class:
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3
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InChIKey:
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ARFHIAQFJWUCFH-IZZDOVSWSA-N
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硝呋替莫性质、用途与生产工艺
硝呋替莫是现在几乎唯一的对这些病原体具有活性的化合物。该活性可能是基于对酶Trypanothione还原酶(一种特殊的锥虫酶)的抑制。这种酶在其他原生动物病原体中是不存在的。
硝呋替莫（nifurtimox）是自20世纪70年代以来治疗南美锥虫病（Chagasdisease）的主要药物，为一种硝基杂环类化合物，在细胞内被还原成硝基阴离子自由基、过氧化氢和超氧化物自由基等活性氧（reactiveoxygenspecies，ROS）。硝呋替莫和其他硝基呋喃化合物能够用于治疗癌症和由血管发生所介导或引起的疾病或病症。
Nifurtimox (BAY-2502) 是一种抗原虫剂。
Trypanosoma cruzi
Lactate dehydrogenase (LDH)
Nifurtimox affects enzyme activity of lactate dehydrogenase (LDH). To differentiate if this effect is a result of a reduced LDH activity or a shift in pyruvate metabolism due to activation of PDH, the enzyme activity of LDH is determined after 4 h treatment with 50 µg/mL Nifurtimox. Compared to the untreated control, the LDH activity is significantly reduced for LA-N-1 (P=0.005), IMR-32 (P=0.009), LS (P=0.0035) and SK-N-SH (P=0.0065). Nifurtimox reduces cell viability and induces cell cycle arrest and apoptosis in neuroblastoma cells. To characterize the cytotoxic impacts of Nifurtimox on neuroblastoma, 4 cell lines are subjected to several experiments. Cell viability is reduced for all 4 neuroblastoma cell lines after 24 h incubation with 50 µg/mL to an average of 66%, 63%, 62% and 75% (LA-N-1, IMR-32 LS and SK-N-SH, respectively). The reduction is significant compared to the untreated control (P<0.01) and the vehicle control with DMSO (P<0.05) for all cell lines.
硝呋替莫
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-W040073 | 硝呋替莫
Nifurtimox | 23256-30-6 | 5mg | 800元 |
| 2024/01/25 | HY-W040073 | 硝呋替莫
Nifurtimox | 23256-30-6 | 10mM * 1mLin DMSO | 880元 |
23256-30-6, 硝呋替莫 相关搜索:
- Sulfur & Selenium Compounds
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Heterocycles
- 高端化学
- 3-甲基-4-(((5-硝基呋喃-2-基)亚甲基)氨基)硫代吗啉 1,1-二氧化物
- 硝呋莫司
- 硝呋替莫
- NIFURTIMOX [4-氨基-3-甲基四氢-1,4-噻嗪-1,1-二氧化物]
- 23256-30-6
- 3-Methyl-4-(((5-nitrofuran-2-yl)methylene)amino)thiomorpholine 1,1-dioxide
- LDH,Lactate Dehydrogenase,Parasite,inhibit,Inhibitor,Nifurtimox
- (±)-Nifurtimox Lampit
- nifurtimox USP/EP/BP
- 4-Thiomorpholinamine, 3-methyl-N-[(5-nitro-2-furanyl)methylene]-, 1,1-dioxide
- BAY-A-2502
- (E)-N-(3-methyl-1,1-dioxo-1,4-thiazinan-4-yl)-1-(5-nitrofuran-2-yl)methanimine
- Thiomorpholine, 3-methyl-4-((5-nitrofurfurylidene)amino)-,1,1-dioxide
- 3-Methyl-4-(5′-nitrofurylidene-amino)-tetrahydro-4H-1,4-thiazine-1,1-dioxide
- (RS)-3-methyl-N-[(1E)-(5-nitro-2-furyl)methylene]thiomorpholin-4-amine 1,1-dioxide
- 3-Methyl-N-[(5-nitro-2-furanyl)Methylene]-
- 3-Methyl-N-[(5-nitro-furan-2-yl)Methylene]-4-thioMorpholinaMine1,1-dioxide
- nifurtimox
- Aids-007325
- Aids007325
- 3-Methyl-N-[(5-nitro-2-furanyl)methylene]-4-thiomorpholinamine 1,1-dioxide
- Lampit
- Bayer-2502
- Bayer 2502
- BAY-2502
- 4-[(5-Nitrofurfurylidene)amino]-3-methylthiomorpholine 1,1-dioxide
- NIFURIMOX