JNK INHIBITOR V CALBIOCHEM
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- CAS号:
- 345987-15-7
- 英文名:
- AS601245
- 英文别名:
- CS-1619;AS601245;AS601245.TFA;JNK Inhibitor V;2-Benzothiazoleacetonitrile, α-[2-[[2-(3-pyridinyl)ethyl]amino]-4-pyrimidinyl]-;alpha-[2-[[2-(3-Pyridinyl)ethyl]amino]-4-pyrimidinyl]-2-benzothiazoleacetonitrile;2-(1,3-benzothiazol-2-yl)-2-[2-(2-pyridin-3-ylethylamino)pyrimidin-4-yl]acetonitrile;2-(Benzo[d]thiazol-2-yl)-2-(2-((2-(pyridin-3-yl)ethyl)amino)pyrimidin-4-yl)acetonitrile;colon,Inhibitor,inhibit,AS-601245,TNF-α,cancer,JNK,cells,neuroprotective,AS601245,release,anti-Inflammatory,AS 601245
- 中文名:
- JNK INHIBITOR V CALBIOCHEM
- 中文别名:
- 化合物AS601245;AS601245.TFA盐;JNK抑制剂(AS601245);AS601245,ATP竞争性JNK抑制剂;JNK INHIBITOR V CALBIOCHEM;ALPHA-[2-[[2-(3-吡啶基)乙基]氨基]-4-嘧啶基]-2-苯并噻唑乙腈;2-(苯并[D]噻唑-2-基)-2-(2-((2-(吡啶-3-基)乙基)氨基)嘧啶-4-基)乙腈
- CBNumber:
- CB42627340
- 分子式:
- C20H16N6S
- 分子量:
- 372.45
- MOL File:
- 345987-15-7.mol
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JNK INHIBITOR V CALBIOCHEM化学性质
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沸点:
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635.6±65.0 °C(Predicted)
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密度:
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1.366±0.06 g/cm3(Predicted)
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储存条件:
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Keep in dark place,Sealed in dry,Store in freezer, under -20°C
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溶解度:
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insoluble in H2O; insoluble in EtOH; ≥14.25 mg/mL in DMSO
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酸度系数(pKa):
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5.32±0.10(Predicted)
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形态:
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White to yellow solid.
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JNK INHIBITOR V CALBIOCHEM性质、用途与生产工艺
AS601245 是一种口服活性、选择性、ATP竞争性的 JNK 抑制剂，IC50 分别为 150、220和 70 nM，对三种 JNK 人类亚型 (hJNK1、hJNK2和hJNK3)。AS601245 对 c-src、CDK2 和 c-Raf 的选择性为 10-20 倍，对一系列 Ser/Thr 和 Tyr 蛋白激酶的选择性为 50-100 倍。具有神经保护特性。
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hJNK1
150 nM (IC
50
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hJNK2
220 nM (IC
50
)
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hJNK3
70 nM (IC
50
)
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AS601245, an anti-Inflammatory JNK inhibitor, and Clofibrate have a synergistic effect in inducing cell responses and in affecting the gene expression profile in CaCo-2 colon cancer cells .
AS601245 (40, 60, and 80 mg/kg; i.p.) provides significant protection against the delayed loss of hippocampal CA1 neurons in a gerbil model of transient global ischemia.
AS601245 (0.3-10 mg/kg; p.o.) is a potent inhibitor of LPS-induced TNF-α release in mice.
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Animal Model:
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C3H/HEN mice
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Dosage:
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0.3, 1, 3, or 10 mg/kg
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Administration:
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P.o.
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Result:
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Decreased the TNF-α release in a dose-dependent manner.
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JNK INHIBITOR V CALBIOCHEM
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-11010 | AS601245 | | 1 mg | 545元 |
| 2024/04/30 | HY-11010 | AS601245 | 345987-15-7 | 5mg | 1200元 |
JNK INHIBITOR V CALBIOCHEM
生产厂家
345987-15-7, JNK INHIBITOR V CALBIOCHEM 相关搜索:
- Inhibitors
- 合成有机化合物配体
- 细胞生物学试剂
- 小分子抑制剂，天然产物
- 小分子抑制剂
- AS601245,ATP竞争性JNK抑制剂
- JNK INHIBITOR V CALBIOCHEM
- 化合物AS601245
- 2-(苯并[D]噻唑-2-基)-2-(2-((2-(吡啶-3-基)乙基)氨基)嘧啶-4-基)乙腈
- JNK抑制剂(AS601245)
- ALPHA-[2-[[2-(3-吡啶基)乙基]氨基]-4-嘧啶基]-2-苯并噻唑乙腈
- AS601245.TFA盐
- 345987-15-7
- colon,Inhibitor,inhibit,AS-601245,TNF-α,cancer,JNK,cells,neuroprotective,AS601245,release,anti-Inflammatory,AS 601245
- 2-(1,3-benzothiazol-2-yl)-2-[2-(2-pyridin-3-ylethylamino)pyrimidin-4-yl]acetonitrile
- CS-1619
- 2-Benzothiazoleacetonitrile, α-[2-[[2-(3-pyridinyl)ethyl]amino]-4-pyrimidinyl]-
- 2-(Benzo[d]thiazol-2-yl)-2-(2-((2-(pyridin-3-yl)ethyl)amino)pyrimidin-4-yl)acetonitrile
- alpha-[2-[[2-(3-Pyridinyl)ethyl]amino]-4-pyrimidinyl]-2-benzothiazoleacetonitrile
- JNK Inhibitor V
- AS601245.TFA
- AS601245