氧化苏木精
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- CAS号:
- 475-25-2
- 英文名:
- HEMATEIN
- 英文别名:
- HEMATEIN;hematine;Hamatein;HAEMATEIN;Hematein,94%;abcolhematinelg;HEMATEIN, STAIN;HYDROXYBRASILEIN;TIMTEC-BB SBB006464;CI75290formicroscopy
- 中文名:
- 氧化苏木精
- 中文别名:
- 苏木因;苏木红;海尔丹;天然黑1;氧化苏木素;氧化苏木精;氧化苏木红
- CBNumber:
- CB4271741
- 分子式:
- C16H12O6
- 分子量:
- 300.26
- MOL File:
- 475-25-2.mol
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氧化苏木精性质、用途与生产工艺
Hematein 是苏木精的氧化产物，可作为染料。Hematein 是一种变构酪蛋白激酶 II 抑制剂，IC50 为 0.74 μM。Hematein 抑制 Akt/PKB Ser129 磷酸化，Wnt/TCF 途径并增加肺癌细胞的凋亡。
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CKII
0.74 μM (IC
50
)
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Akt
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Wnt
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Hematein (10-100 μM; 14 days) inhibits cells growth in A427 lung cancer cells.
Hematein (50 and 100 μM; 48 hours) induces apoptosis in A427 lung cancer cells.
Hematein (50 and 100 μM; 48 hours) inhibits CK2-specific Akt phosphorylation.
Cell Viability Assay
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Cell Line:
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A427 (HTB-53) cell line
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Concentration:
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10-100 μM
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Incubation Time:
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14 days
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Result:
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Inhibited cells growth.
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Apoptosis Analysis
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Cell Line:
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A427 (HTB-53) cell line
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Concentration:
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50 and 100 μM
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Incubation Time:
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48 hours
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Result:
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Induced apoptosis in A427 lung cancer cells.
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Western Blot Analysis
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Cell Line:
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A427 (HTB-53) cell line
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Concentration:
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50 and 100 μM
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Incubation Time:
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48 hours
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Result:
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Inhibited CK2-specific Akt phosphorylation.
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Hematein (intraperitoneal injections; 50 mg/kg; twice a week for 6 weeks) inhibits tumor growth in A427 lung cancer cell xenografts.
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Animal Model:
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Female athymic BALB/c nude mice (6-week-old)
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Dosage:
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50 mg/kg
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Administration:
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Intraperitoneal injections; twice a week for 6 weeks
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Result:
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Inhibited tumor growth in A427 lung cancer cell xenografts.
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氧化苏木精
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/16 | C37084 | 氧化苏木精
Hematein | 475-25-2 | 5g | 718元 |
| 2024/01/16 | C37084 | 氧化苏木精
Hematein | 475-25-2 | 25g | 3861元 |
氧化苏木精
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475-25-2, 氧化苏木精 相关搜索:
- Stains&Dyes, A to
- Stains and Dyes
- G-H-I
- 生化试剂
- 分析试剂-染料中间体
- 氧化苏木素
- 氧化苏木精
- 氧化苏木红
- 天然黑1
- 苏木因
- 苏木红
- 海尔丹
- 475-25-2
- Hematein (Technical Grade)
- 3,4,6a,10-tetrahydroxy-6,7-dihydroindeno[2,1-c][1]benzopyran-9-one
- HEMATEIN, STAIN
- Benzbindeno1,2-dpyran-9(6H)-one, 6a,7-dihydro-3,4,6a,10-tetrahydroxy-
- CI75290formicroscopy
- HEMATEIN C.I. 75290 FOR MICROSCOPY
- HEMATEIN FROM LOGWOOD
- Hematein,94%
- Hamatein
- 6a,7-dihydro-3,4,6a,10-tetrahydroxybenz[b]indeno[1,2-d]pyran-9(6H)-one
- hematine
- abcolhematinelg
- 3,4,6a,10-tetrahydroxy-6a,7-dihydrobenz(b)indeno(1,2-d)pyran-9(6h)-one
- 2-d]pyran-9(6h)-one,6a,7-dihydro-3,4,6a,10-tetrahydroxy-benz[b]indeno[
- 2-d)pyran-9(6h)-one,6a,7-dihydro-3,4,6a,10-tetrahydroxy-benz(b)indeno(
- HAEMATEIN
- HEMATEIN
- HYDROXYBRASILEIN
- LABOTEST-BB LT00441274
- HEMATEIN FOR MICROSCOPY
- TIMTEC-BB SBB006464