11β-羟基雄甾-4-烯-3,17-二酮
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- CAS号:
- 382-44-5
- 英文名:
- 11β-Hydroxyandrost-4-ene-3,17-dione
- 英文别名:
- u 2826;-dione;diol-d10;14αDecadiene;(17R)-4’4-Androsten-11;H)-furan]-3,3’Cortisone Impurity 1;Anthraceneacetic Acid
- 中文名:
- 11β-羟基雄甾-4-烯-3,17-二酮
- 中文别名:
- 17-二酮;可的松杂质1;11Β-羟基雄甾-4-烯-3;4-雄烯-11Β-醇-3,17-二酮;4-雄甾烯-11-醇-3,17-二酮;4-雄烯-11β-醇-3,17-二酮;11β-羟基雄甾-4-烯-3,17-二酮;11Β-羟基雄甾-4-烯-3,17-二酮;11b-羟基-雄甾-4-烯-3,17-二酮;4-雄甾烯11Β-醇-3,17二酮-[D7]
- CBNumber:
- CB6136789
- 分子式:
- C19H26O3
- 分子量:
- 302.41
- MOL File:
- 382-44-5.mol
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11β-羟基雄甾-4-烯-3,17-二酮化学性质
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熔点:
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197-199℃
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沸点:
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475.3±45.0 °C(Predicted)
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密度:
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1.19±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 250 mg/mL (826.69 mM)
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形态:
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A crystalline solid
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酸度系数(pKa):
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14.49±0.60(Predicted)
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11β-羟基雄甾-4-烯-3,17-二酮性质、用途与生产工艺
11-Beta-hydroxyandrostenedione (4-Androsten-11β-ol-3,17-dione) 是一种主要存在于肾上腺的类固醇 (11β-羟化酶存在于肾上腺组织，但在卵巢组织中不存在)。11-Beta-hydroxyandrostenedione 是一种 11β-羟基类固醇脱氢酶 (11βHSD) 同工酶抑制剂。随着 4-androstenedione 的增加，测量血浆 11-Beta-hydroxyandrostenedione 可以区分高雄激素血症的肾上腺或卵巢起源。
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Human Endogenous Metabolite
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In order to establish that this conversion is catalysed by the lyase activity of CYP17A1, 21-deoxycortisol (21dF) and 21-deoxycortisone (21dE) is assayed within the LNCaP cell line. Upon the transfection of CYP17A1, 11-Beta-hydroxyandrostenedione (11OHA4)-pathway metabolites increase, 21dF and 21dE are in fact metabolised to 11-Beta-hydroxyandrostenedione and 11-ketoprogesterone (11KP4) by CYP17A1, respectively.
The plasma concentration of 11-Beta-hydroxyandrostenedione (11beta-hydroxy-4-androstene-3,17-dione) is very high in 21-hydroxylase deficiency, Cushing's syndrome, and hyperandrogenism of adrenal origin, and very low in congenital 11-hydroxylase deficiency and adrenal insufficiency. Thus, when plasma 4-androstenedione is elevated, it is useful to measure the plasma 11-Beta-hydroxyandrostenedione level in order to determine the adrenal or ovarian origin of the hyperandrogenism.
11β-羟基雄甾-4-烯-3,17-二酮
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-114464 | 4-雄烯-11β-醇-3,17-二酮
11-Beta-hydroxyandrostenedione | 382-44-5 | 5mg | 500元 |
| 2024/01/25 | HY-114464 | 4-雄烯-11β-醇-3,17-二酮
11-Beta-hydroxyandrostenedione | 382-44-5 | 10mM * 1mLin DMSO | 550元 |
11β-羟基雄甾-4-烯-3,17-二酮
生产厂家
382-44-5, 11β-羟基雄甾-4-烯-3,17-二酮 相关搜索:
- Steroids
- 药靶配体
- 抑制剂
- 激素原料
- 内分泌与激素
- 细胞生物学
- Steroid Hormones
- Cytokines, Growth Factors and Hormones
- Hormones
- Cell Signaling and Neuroscience
- Cell Biology
- BioChemical
- Androgen
- 可的松杂质1
- 11Β-羟基雄甾-4-烯-3,17-二酮(氢化可的松杂质)
- 11b-羟基-雄甾-4-烯-3,17-二酮
- 11Β-羟基雄甾-4-烯-3,17-二酮
- 4-雄烯-11Β-醇-3,17-二酮
- 4-雄甾烯-11Β-醇-3,17-二酮-2,2,4,6,6,16,16-D7
- 4-雄甾烯11Β-醇-3,17二酮-[D7]
- 4-雄烯-11B-醇-3,17-二酮(2,2,4,6,6,16,16-D7,98%)
- 4-雄甾烯-11Β-OL-3,17-二酮-2,2,4,6,6,16,16-D7
- 4-雄甾烯-11-醇-3,17-二酮
- 17-二酮
- 11Β-羟基雄甾-4-烯-3
- 11BETA-羟基-4-雄甾烯-3,17-二酮
- 4-雄烯-11β-醇-3,17-二酮
- 11β-羟基雄甾-4-烯-3,17-二酮
- 382-44-5
- Cortisone Impurity 1
- Androst-4-ene-3,17-dione, 11-hydroxy-, (11β)-
- 11β-Hydroxyandrost-4-ene-3,17-dione
- 11Betahydroxyandrostenedione,inhibit,4-androstenedione,Cushing's,hyperandrogenism,adrenal,syndrome,Inhibitor,Endogenous Metabolite,steroid,11 Beta hydroxyandrostenedione,11β-hydroxylase,ovarian
- 11b-Hydroxyandrost-4-ene-3,17-dione
- 11β-Hydroxy-4-androstene-3,17-dione
- 4-Androsten-11β-ol-3,17-dione
- "4-Androsten-11--ol-3,17dione D5"
- 4-Androsten-11β-ol-3,17-dione-2,2,4,6,6,16,16-d7
- Hydrocortisone Impurity 3
- 14&alpha
- Anthraceneacetic Acid
- diol-d10
- HYDROCORTISONE IMPURITY 1
- Taxilin, alpha (TXLNA) TXLN-alpha, IL
- Decadiene
- -methylspiro[androsta-1,4-diene-17,2&rsquo
- H)-furan]-3,3&rsquo
- -ethyl-9-fluoro-11&beta
- (17R)-4&rsquo
- -dione
- -11-Hydroxy-10,13-dimethyl-7,8,9,10,11,12,13,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17(2H,6H)
- (8S,9S,10R,11S,13S,14S)
- 4-Androsten-11
- 4- androstene-3,17-dione -11β- alcohol
- (8S,9S,10R,11S,13S,14S)-11-hydroxy-10,13-diMethyl-7,8,9,10,11,12,13,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17(2H,6H)-dione
- (11beta)-11-Hydroxyandrost-4-ene-3,17-dione
- 4-Androsten-11-ol-3,17-dione-d7
- (8S,9S,10R,11S,13S,14S)-11-hydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17-quinone