11β-羟基雄甾-4-烯-3,17-二酮
中文名称 | 11β-羟基雄甾-4-烯-3,17-二酮 |
---|---|
中文同义词 | 11β-羟基雄甾-4-烯-3,17-二酮;4-雄烯-11β-醇-3,17-二酮;11BETA-羟基-4-雄甾烯-3,17-二酮;11Β-羟基雄甾-4-烯-3;17-二酮;4-雄甾烯-11-醇-3,17-二酮;4-雄甾烯-11Β-OL-3,17-二酮-2,2,4,6,6,16,16-D7;4-雄烯-11B-醇-3,17-二酮(2,2,4,6,6,16,16-D7,98%) |
英文名称 | 11β-Hydroxyandrost-4-ene-3,17-dione |
英文同义词 | 11beta-Hydroxy-4-androsten-3,17-dione;11-Hydroxyandrost-4-ene-3,17-dione;4-Androstene-11beta-ol-3,17-dione;Androst-4-ene-3,17-dione, 11beta-hydroxy-;Androst-4-ene-3,17-dione, 11-hydroxy-, (11beta)-;u 2826;11-BETA-HYDROXYANDROSTENEDIONE;11BETA-HYDROXY-4-ANDROSTENE-3,17-DIONE |
CAS号 | 382-44-5 |
分子式 | C19H26O3 |
分子量 | 302.41 |
EINECS号 | |
相关类别 | 细胞生物学;内分泌与激素;激素原料;Steroids |
Mol文件 | 382-44-5.mol |
结构式 |
11β-羟基雄甾-4-烯-3,17-二酮 性质
熔点 | 197-199℃ |
---|---|
沸点 | 475.3±45.0 °C(Predicted) |
密度 | 1.19±0.1 g/cm3(Predicted) |
储存条件 | Store at -20°C |
溶解度 | 二甲基亚砜:250 mg/mL(826.69 mM) |
形态 | 结晶固体 |
酸度系数(pKa) | 14.49±0.60(Predicted) |
Human Endogenous Metabolite
|
In order to establish that this conversion is catalysed by the lyase activity of CYP17A1, 21-deoxycortisol (21dF) and 21-deoxycortisone (21dE) is assayed within the LNCaP cell line. Upon the transfection of CYP17A1, 11-Beta-hydroxyandrostenedione (11OHA4)-pathway metabolites increase, 21dF and 21dE are in fact metabolised to 11-Beta-hydroxyandrostenedione and 11-ketoprogesterone (11KP4) by CYP17A1, respectively.
The plasma concentration of 11-Beta-hydroxyandrostenedione (11beta-hydroxy-4-androstene-3,17-dione) is very high in 21-hydroxylase deficiency, Cushing's syndrome, and hyperandrogenism of adrenal origin, and very low in congenital 11-hydroxylase deficiency and adrenal insufficiency. Thus, when plasma 4-androstenedione is elevated, it is useful to measure the plasma 11-Beta-hydroxyandrostenedione level in order to determine the adrenal or ovarian origin of the hyperandrogenism.
安全信息
WGK Germany | 3 |
---|
提供商 | 语言 |
---|---|
英文
|