RNA Polymerase III Inhibitor
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- CAS号:
- 577784-91-9
- 英文名:
- RNA Polymerase III Inhibitor
- 英文别名:
- RNA Polymerase III Inhibitor;RNA Polymerase III Inhibitor inhibitor;RNA Polymerase III Inhibitor - CAS 577784-91-9 - Calbiochem;InSolution RNA Polymerase III Inhibitor - CAS 577784-91-9 - Calbiochem;2-chloro-N-[5-(5-chloro-3-methyl-1-benzothiophen-2-yl)-2-methylpyrazol-3-yl]benzenesulfonamide;Benzenesulfonamide, 2-chloro-N-[3-(5-chloro-3-methylbenzo[b]thien-2-yl)-1-methyl-1H-pyrazol-5-yl]-;transcription,inhibit,broad-spectrum,ML-60218,Inhibitor,viroplasms,ML 60218,yeast,DNA/RNA Synthesis,ML60218
- 中文名:
- RNA Polymerase III Inhibitor
- 中文别名:
- 化合物ML-60218
- CBNumber:
- CB63136764
- 分子式:
- C19H15Cl2N3O2S2
- 分子量:
- 452.38
- MOL File:
- 577784-91-9.mol
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RNA Polymerase III Inhibitor化学性质
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储存条件:
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= -70C
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溶解度:
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Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 5 mg/ml with warming)
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形态:
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Off-white solid
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颜色:
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Off-white
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稳定性:
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Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
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RNA Polymerase III Inhibitor性质、用途与生产工艺
ML-60218 是一种广谱 RNA pol III 抑制剂，对酿酒酵母和人类 RNA pol III 的 IC50 分别为 32 和 27 μM。ML-60218 破坏已经组装好的病毒体，并且在不需要重新转录细胞 RNA 的情况下阻碍新病毒体的形成。
Combination of SAHA and ML-60218 produces enhanced suppression of proliferation in human pancreatic adenocarcinoma by impairing cell cycle progression and inducing apoptosis. ML-60218 reverses SAHA-stimulated tRNA expression in PANC-1 and BxPC-3 cells. ML-60218 enhances the ability of HDAC inhibitors to induce apoptosis and cell cycle arrest.
In in vitro transcription assays with purified double-layered particles (DLPs), ML-60218 shows dose-dependent inhibitory activity, indicating the viral nature of its target. ML-60218 is found to interfere with the formation of higher-order structures of VP6, the protein forming the DLP outer layer, without compromising its ability to trimerize. Electron microscopy of ML-60218-treated DLPs shows dose-dependent structural damage. ML-60218-mediated (10 μM ) viroplasm disruption causes NSP5 dephosphorylation.
RNA Polymerase III Inhibitor
上下游产品信息
上游原料
下游产品
RNA Polymerase III Inhibitor
生产厂家
577784-91-9, RNA Polymerase III Inhibitor 相关搜索:
- 化合物ML-60218
- 577784-91-9
- RNA Polymerase III Inhibitor inhibitor
- transcription,inhibit,broad-spectrum,ML-60218,Inhibitor,viroplasms,ML 60218,yeast,DNA/RNA Synthesis,ML60218
- Benzenesulfonamide, 2-chloro-N-[3-(5-chloro-3-methylbenzo[b]thien-2-yl)-1-methyl-1H-pyrazol-5-yl]-
- RNA Polymerase III Inhibitor - CAS 577784-91-9 - Calbiochem
- InSolution RNA Polymerase III Inhibitor - CAS 577784-91-9 - Calbiochem
- 2-chloro-N-[5-(5-chloro-3-methyl-1-benzothiophen-2-yl)-2-methylpyrazol-3-yl]benzenesulfonamide
- RNA Polymerase III Inhibitor