5-([1,1'-联苯]-4-甲基)-N,N-二甲基-1H-四氮唑-1-甲酰胺
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- CAS号:
- 874902-19-9
- 英文名:
- 5-[[(1,1'-BIPHENYL)-4-YL]METHYL]-N,N-DIMETHYL-1H-TETRAZOLE-1-CARBOXAMIDE
- 英文别名:
- CS-752;LY 2183240;LY2183240 powder;LY-2183240 MN-25;LY2183240/LY-2183240;N,N-dimethyl-5-[(4-phenylphenyl)methyl]tetrazole-1-carboxamide;5-(biphenyl-4-ylMethyl)-N,N-diMethyl-1H-tetrazole-1-carboxaMide;5-Biphenyl-4-ylmethyl-tetrazole-1-carboxylic acid dimethylamide;1H-Tetrazole-1-carboxamide, 5-([1,1′-biphenyl]-4-ylmethyl)-N,N-dimethyl-;5-[[(1,1'-BIPHENYL)-4-YL]METHYL]-N,N-DIMETHYL-1H-TETRAZOLE-1-CARBOXAMIDE
- 中文名:
- 5-([1,1'-联苯]-4-甲基)-N,N-二甲基-1H-四氮唑-1-甲酰胺
- 中文别名:
- 化合物LY2183240;LY2183240,花生四烯酸摄取抑制剂;5-([1,1'-联苯]-4-甲基)-N,N-二甲基-1H-四氮唑-1-甲酰胺
- CBNumber:
- CB7842012
- 分子式:
- C17H17N5O
- 分子量:
- 307.35
- MOL File:
- 874902-19-9.mol
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5-([1,1'-联苯]-4-甲基)-N,N-二甲基-1H-四氮唑-1-甲酰胺化学性质
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熔点:
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87-88℃
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沸点:
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506.1±53.0 °C(Predicted)
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密度:
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1.21
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储存条件:
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Sealed in dry,2-8°C
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溶解度:
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Soluble in DMSO (greater than 25 mg/ml) or in Ethanol (up to 15 mg/ml).
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酸度系数(pKa):
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0.01±0.10(Predicted)
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形态:
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White to off-white solid.
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颜色:
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White
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稳定性:
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Stable for 1 year as supplied. Solutions in DMSO of ethanol may be stored at -20°C for up to 1 month
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5-([1,1'-联苯]-4-甲基)-N,N-二甲基-1H-四氮唑-1-甲酰胺性质、用途与生产工艺
LY-2183240 是一种有效的EC降解酶 fatty acid amide hydrolase (FAAH) 的共价抑制剂。 LY-2183240 破坏脂类内源性大麻素(EC)的细胞摄取,并在体内促进镇痛作用。LY-2183240 也是一种 monoacylgylcerol lipase (MGL) 的抑制剂。
Target | Value |
FAAH
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MGL
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LY2183240 (3-30mg/kg; i.p.) dose-dependently attenuates formalin-induced paw-licking pain behavior in the formalin model of persistent pain mechanisms.
Animal Model:
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Male Sprague-Dawley rats (Formalin Pain Model)
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Dosage:
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3, 10, 30 mg/kg
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Administration:
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I.p.
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Result:
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Dose-dependently attenuated formalin-induced paw-licking pain behavior in the formalin model of persistent pain mechanisms.
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5-([1,1'-联苯]-4-甲基)-N,N-二甲基-1H-四氮唑-1-甲酰胺
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/01/25 | HY-10865 | LY2183240 | | 1 mg | 160元 |
2024/01/25 | HY-10865 | LY2183240 | | 5 mg | 400元 |
5-([1,1'-联苯]-4-甲基)-N,N-二甲基-1H-四氮唑-1-甲酰胺
生产厂家
874902-19-9, 5-([1,1'-联苯]-4-甲基)-N,N-二甲基-1H-四氮唑-1-甲酰胺 相关搜索:
- 药靶配体
- 生物活性分子
- 神经信号
- LY2183240,花生四烯酸摄取抑制剂
- 化合物LY2183240
- 5-([1,1'-联苯]-4-甲基)-N,N-二甲基-1H-四氮唑-1-甲酰胺
- 874902-19-9
- Inhibitor,brain,uptake,transport,hydrolases,Fatty acid amide hydrolase,LY2183240,Autophagy,LY 2183240,serine,anandamide,FAAH,inhibit,LY-2183240
- LY2183240 powder
- CS-752
- LY2183240/LY-2183240
- 5-(biphenyl-4-ylMethyl)-N,N-diMethyl-1H-tetrazole-1-carboxaMide
- N,N-dimethyl-5-[(4-phenylphenyl)methyl]tetrazole-1-carboxamide
- 5-Biphenyl-4-ylmethyl-tetrazole-1-carboxylic acid dimethylamide
- 1H-Tetrazole-1-carboxamide, 5-([1,1′-biphenyl]-4-ylmethyl)-N,N-dimethyl-
- LY-2183240 MN-25
- LY 2183240
- 5-[[(1,1'-BIPHENYL)-4-YL]METHYL]-N,N-DIMETHYL-1H-TETRAZOLE-1-CARBOXAMIDE