盐酸双芬麦兰
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- CAS号:
- 62232-46-6
- 英文名:
- Bifemelane HCl
- 英文别名:
- Bifemelane HCl;Bifemelan hydrochloride;Bifemelane hydrochloride;MEAHDXWXNNDSAK-UHFFFAOYSA-N;4-(2-Benzylphenoxy)-N-methylbutan-1-amine hydrochloride;inhibit,Inhibitor,Monoamine Oxidase,MAO-A,MAO,MCI 2016,Bifemelane hydrochloride,antidepressant,Bifemelane,monoamine,MCI-2016,MCI2016,oxidase,MAO-B
- 中文名:
- 盐酸双芬麦兰
- 中文别名:
- 盐酸双芬麦兰;4-(2-苄基苯氧基)-N-甲基丁-1-胺盐酸盐;化合物BIFEMELANE HYDROCHLORIDE;BIFEMELANE HYDROCHLORIDE,MAO抑制剂
- CBNumber:
- CB7947364
- 分子式:
- C18H23NO.ClH
- 分子量:
- 305.847
- MOL File:
- 62232-46-6.mol
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盐酸双芬麦兰化学性质
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熔点:
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117-121°
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溶解度:
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Soluble to 100 mM in water and to 100 mM in DMSO
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形态:
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Powder
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颜色:
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White to yellow
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盐酸双芬麦兰性质、用途与生产工艺
Bifemelane hydrochloride (MCI-2016) 是一种有效,选择性和竞争性的单胺氧化酶 A (MAO-A) 抑制剂,Ki 值为 4.20 μM,它也非竞争性地抑制 MAO-B,Ki 为 46.0 μM。Bifemelane hydrochloride 具有很强的抗抑郁活性,可用于研究与脑血管疾病有关的认知和情绪障碍。
MAO-A
4.2 μM (Ki)
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MAO-B
46 μM (Ki)
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Bifemelane inhibits MAO-A in a dose-dependent manner, with K
i
s of 4.2±0.2 and 14.1±0.7 μM in human brain synaptosomes and human liver mitochondria respectively.
Bifemelane inhibits MAO-B activities in a dose-dependent manner, with K
i
s of 46.0±3.6 and 65.2±7.0 μM in human brain synaptosomes and human liver mitochondria respectively.
Bifemelane (20-80 mg/kg; i.p.) dose-dependently decreases exploratory activity in the open field test.
Bifemelane (20-80 mg/kg; i.p.) decreases immobility time in the forced swim test, although is not clearly dosedependent and has already reached ceiling at 20 mg/kg.
Animal Model:
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Wistar male rats (230-270 g) are induced hypothermia by Reserpine
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Dosage:
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20, 40, 80 mg/kg
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Administration:
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A single i.p.
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Result:
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Attenuated the Reserpine-induced hypothermia by a maximum of 10 ℃.
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盐酸双芬麦兰
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-B1558A | Bifemelane hydrochloride | | 1 mg | 285元 |
2024/08/19 | HY-B1558A | Bifemelane HCl Bifemelane hydrochloride | 62232-46-6 | 5mg | 750元 |
62232-46-6, 盐酸双芬麦兰 相关搜索:
- 酶
- BIFEMELANE HYDROCHLORIDE,MAO抑制剂
- 4-(2-苄基苯氧基)-N-甲基丁-1-胺盐酸盐
- 化合物BIFEMELANE HYDROCHLORIDE
- 盐酸双芬麦兰
- 62232-46-6
- inhibit,Inhibitor,Monoamine Oxidase,MAO-A,MAO,MCI 2016,Bifemelane hydrochloride,antidepressant,Bifemelane,monoamine,MCI-2016,MCI2016,oxidase,MAO-B
- 4-(2-Benzylphenoxy)-N-methylbutan-1-amine hydrochloride
- MEAHDXWXNNDSAK-UHFFFAOYSA-N
- Bifemelan hydrochloride
- Bifemelane hydrochloride
- Bifemelane HCl