盐酸双芬麦兰
| 中文名称 | 盐酸双芬麦兰 |
|---|---|
| 中文同义词 | 盐酸双芬麦兰;化合物BIFEMELANE HYDROCHLORIDE;4-(2-苄基苯氧基)-N-甲基丁-1-胺盐酸盐;BIFEMELANE HYDROCHLORIDE,MAO抑制剂 |
| 英文名称 | Bifemelane HCl |
| 英文同义词 | Bifemelane HCl;Bifemelane hydrochloride;Bifemelan hydrochloride;MEAHDXWXNNDSAK-UHFFFAOYSA-N;4-(2-Benzylphenoxy)-N-methylbutan-1-amine hydrochloride;inhibit,Inhibitor,Monoamine Oxidase,MAO-A,MAO,MCI 2016,Bifemelane hydrochloride,antidepressant,Bifemelane,monoamine,MCI-2016,MCI2016,oxidase,MAO-B |
| CAS号 | 62232-46-6 |
| 分子式 | C18H23NO.ClH |
| 分子量 | 305.847 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 62232-46-6.mol |
| 结构式 |  |
盐酸双芬麦兰 性质
| 熔点 | 117-121° |
|---|---|
| 溶解度 | 在水中溶解度为 100 mM，在 DMSO 中溶解度为 100 mM |
| 形态 | 粉末 |
|
MAO-A 4.2 μM (Ki) |
MAO-B 46 μM (Ki) |
Bifemelane inhibits MAO-A in a dose-dependent manner, with K
i
s of 4.2±0.2 and 14.1±0.7 μM in human brain synaptosomes and human liver mitochondria respectively.
Bifemelane inhibits MAO-B activities in a dose-dependent manner, with K
i
s of 46.0±3.6 and 65.2±7.0 μM in human brain synaptosomes and human liver mitochondria respectively.
Bifemelane (20-80 mg/kg; i.p.) dose-dependently decreases exploratory activity in the open field test.
Bifemelane (20-80 mg/kg; i.p.) decreases immobility time in the forced swim test, although is not clearly dosedependent and has already reached ceiling at 20 mg/kg.
| Animal Model: | Wistar male rats (230-270 g) are induced hypothermia by Reserpine |
| Dosage: | 20, 40, 80 mg/kg |
| Administration: | A single i.p. |
| Result: | Attenuated the Reserpine-induced hypothermia by a maximum of 10 ℃. |
安全信息
| 毒性 | LD50 in mice, rats (mg/kg): 1000, 1080 orally; 173, 130 i.p. (Tobe, 1981) |
|---|
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-B1558A | Bifemelane hydrochloride | 1 mg | 285元 | |
| 2024/01/25 | HY-B1558A | Bifemelane HCl Bifemelane hydrochloride | 62232-46-6 | 5mg | 750元 |