多粘菌素B1
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- CAS号:
- 4135-11-9
- 英文名:
- polymyxin B(1)
- 英文别名:
- polymyxin B(1);Glucosamine Hydrochloride Impurity 33;polymyxin B1Q: What is
polymyxin B1 Q: What is the CAS Number of
polymyxin B1;(-)-N2-[[(6S)-6-Methyloctanoyl]-L-A2bu-L-Thr-L-A2bu-]cyclo(L-A2bu*-L-A2bu-D-Phe-L-Leu-L-A2bu-L-A2bu-L-Thr-);(6S)-N-[(2S)-4-amino-1-[[(2S,3R)-1-[[(2S)-4-amino-1-oxo-1-[[(3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-3-[(1R)-1-hydroxyethyl]-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxobutan-2-yl]-6-methyloctanamide
- 中文名:
- 多粘菌素B1
- 中文别名:
- 多粘菌素B1;多黏菌素 B1;多粘菌素B1 POLYMYXIN B1
- CBNumber:
- CB81388907
- 分子式:
- C56H98N16O13
- 分子量:
- 1203.48
- MOL File:
- 4135-11-9.mol
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多粘菌素B1化学性质
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沸点:
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838.79°C (rough estimate)
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密度:
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1.0500 (rough estimate)
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折射率:
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1.6200 (estimate)
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储存条件:
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Store at -20°C
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溶解度:
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PBS (pH 7.2): 2 mg/ml
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形态:
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A crystalline solid
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酸度系数(pKa):
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13.08±0.70(Predicted)
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多粘菌素B1性质、用途与生产工艺
Polymyxin B1 是一种有效的抗菌脂肽，衍生自多头芽孢杆菌。Polymyxin B1 是 Polymyxin B (HY-A0248) 的主要成分。Polymyxin B1 可以通过与细菌细胞膜的相互作用来诱导细菌细胞裂解。Polymyxin B1 可用于多重耐药性革兰氏阴性菌感染的研究。
Polymyxin B1 has antimicrobial activity that againsts
Pseudomonas aeruginosa
ATCC 27853,
Acinetobacter baumannii
ATCC BAA 747,
Klebsiella pneumoniae
ATCC 13883,
P. aeruginosa
9019,
A. baumannii
1261 and
K. pneumoniae
VM9 isolates with MIC values of 4 μg/mL, 2 μg/mL, 2 μg/mL, 4 μg/mL, 4 μg/mL and 2 μg/mL, respectively.
Polymyxin B1 strongly inhibits protein synthesis in yeast, and in
E. coli
and
S. aureus
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The pharmacokinetics of Polymyxin B1 is investigated in a rat model following intravenous administration (0.8 mg/kg). The area under the concentration-time curve for Polymyxins B1 is greater than those of colistins A and B. Colistin A colistin B. The clearance value of Polymyxins B1 is 2.39 mL/min/kg, the plasma protein binding is 82.3%, the elimination half-life is 79.5 min and the AUC
0-∞
is 365 mg•min/L.
多粘菌素B1
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-A0248A | polymyxin B(1)
Polymyxin B1 | 4135-11-9 | 1mg | 2400元 |
4135-11-9, 多粘菌素B1 相关搜索:
- 药靶配体
- 多粘菌素
- 目录肽
- 其它杂质
- 化药杂质-多粘菌素
- C56H98N16O13
- 多粘菌素B1 POLYMYXIN B1
- 多黏菌素 B1
- 多粘菌素B1
- 4135-11-9
- Glucosamine Hydrochloride Impurity 33
- polymyxin B1Q: What is
polymyxin B1 Q: What is the CAS Number of
polymyxin B1
- (6S)-N-[(2S)-4-amino-1-[[(2S,3R)-1-[[(2S)-4-amino-1-oxo-1-[[(3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-3-[(1R)-1-hydroxyethyl]-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxobutan-2-yl]-6-methyloctanamide
- (-)-N2-[[(6S)-6-Methyloctanoyl]-L-A2bu-L-Thr-L-A2bu-]cyclo(L-A2bu*-L-A2bu-D-Phe-L-Leu-L-A2bu-L-A2bu-L-Thr-)
- polymyxin B(1)