L-692,429 , CID121879
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- CAS号:
- 145455-23-8
- 英文名:
- L 692429
- 英文别名:
- MK 0751;L 692429;L692429,L 692429;L-692429 free base;L-692,429 , CID121879;3-amino-3-methyl-N-[(3R)-2-oxo-1-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-4,5-dihydro-3H-1-benzazepin-3-yl]butanamide;(R)-N-(1-((2'-(2H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl)-3-amino-3-methylbutanamide;Butanamide, 3-amino-3-methyl-N-[(3R)-2,3,4,5-tetrahydro-2-oxo-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-1-benzazepin-3-yl]-
- 中文名:
- L-692,429 , CID121879
- 中文别名:
- 化合物 T11798;化合物 L-692429
- CBNumber:
- CB91351663
- 分子式:
- C29H31N7O2
- 分子量:
- 509.611
- MOL File:
- 145455-23-8.mol
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L-692,429 , CID121879化学性质
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密度:
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1.33±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 50 mg/mL (98.12 mM)
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酸度系数(pKa):
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4.14±0.10(Predicted)
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形态:
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Solid
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颜色:
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White to off-white
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L-692,429 , CID121879性质、用途与生产工艺
L-692429 (MK-0751) 是一种苯并内酰胺的衍生物，也是一种非肽基生长激素促分泌素 (GHS) 激动剂。L-692429 以 Ki 值为 63 nM 来结合 G 蛋白偶联受体 (G protein-coupled receptor)。
Growth hormone secretagogue (GHS)
L-692429 stimulates intracellular calcium release, inositol phosphate (IP) turnover, cAMP-responsive element binding protein (CREB) activity, serum-responsive element activity and bioluminescence resonance energy transfer (BRET) activity with EC
50
values of 26 nM, 47 nM, 60 nM, 63 nM and 58 nM, respectively.
HeLa-T4 cells transiently expressing the flag epitope-tagged growth hormone secretagogue (GHS) receptor are treated with L-692429. The release of intracellular calcium is measured using fluorometry with the calcium indicator dye fluo-3/AM. Untransfected HeLa-T4 cells are unresponsive to L-692429 treatment, whereas HeLa-T4 cells transiently expressing GHS receptors demonstrate an increase in fluorescent emission after L-692429 treatment. A significant increase in luciferase activity after L-692429 treatment is seen, suggesting that activation of the GHS receptor stimulates the MAPK pathway.
When tested in anesthetized rats (Wistar rats), L-756867 inhibits L-692429 (100 μg/kg)-stimulated GH secretion in a dose-dependent manner. Complete inhibition is observed at an i.v. dose of 100 μg/kg of L-756867.
L-692,429 , CID121879
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2025/05/22 | HY-10957 | L-692429 | 145455-23-8 | 1 mg | 2181元 |
| 2025/05/22 | HY-10957 | L-692,429 , CID121879
L-692429 | 145455-23-8 | 5mg | 4800元 |
L-692,429 , CID121879
生产厂家
145455-23-8, L-692,429 , CID121879 相关搜索:
- 抑制剂
- 化合物 L-692429
- 化合物 T11798
- 145455-23-8
- (R)-N-(1-((2'-(2H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl)-3-amino-3-methylbutanamide
- L-692429 free base
- Butanamide, 3-amino-3-methyl-N-[(3R)-2,3,4,5-tetrahydro-2-oxo-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-1-benzazepin-3-yl]-
- L692429,L 692429
- L-692,429 , CID121879
- 3-amino-3-methyl-N-[(3R)-2-oxo-1-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-4,5-dihydro-3H-1-benzazepin-3-yl]butanamide
- MK 0751
- L 692429