L 692429
- CAS No.
- 145455-23-8
- Chemical Name:
- L 692429
- Synonyms
- MK 0751;L 692429;L692429,L 692429;L-692429 free base;L-692,429 , CID121879;3-amino-3-methyl-N-[(3R)-2-oxo-1-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-4,5-dihydro-3H-1-benzazepin-3-yl]butanamide;3-amino-3-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-1-benzazepin-3(R)-yl]-butanamide;(R)-N-(1-((2'-(2H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl)-3-amino-3-methylbutanamide;Butanamide, 3-amino-3-methyl-N-[(3R)-2,3,4,5-tetrahydro-2-oxo-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-1-benzazepin-3-yl]-
- CBNumber:
- CB91351663
- Molecular Formula:
- C29H31N7O2
- Molecular Weight:
- 509.611
- MDL Number:
- MFCD00871604
- MOL File:
- 145455-23-8.mol
- MSDS File:
- SDS
| Density | 1.33±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | Store at -20°C |
| solubility | DMSO: 50 mg/mL (98.12 mM) |
| pka | 4.14±0.10(Predicted) |
| form | Solid |
| color | White to off-white |
| FDA UNII | 6GM6ZN5S1Y |
L 692429 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | VFA45523 | L-692429 | 145455-23-8 | 1mg | $250 | 2026-06-05 | Buy |
| Biosynth | VFA45523 | L-692429 | 145455-23-8 | 5mg | $506.2 | 2026-06-05 | Buy |
| Biosynth | VFA45523 | L-692429 | 145455-23-8 | 10mg | $810 | 2026-06-05 | Buy |
| Biosynth | VFA45523 | L-692429 | 145455-23-8 | 25mg | $1518.75 | 2026-06-05 | Buy |
| Biosynth | VFA45523 | L-692429 | 145455-23-8 | 50mg | $2429.5 | 2026-06-05 | Buy |
L 692429 Chemical Properties, Uses, Production
Uses
L-692429 (MK-0751) is a benzolactam derivative and a nonpeptidyl growth hormone secretagogue (GHS) agonist. L-692429 binds to G protein-coupled receptor with a Ki of 63 nM[1][2].
in vivo
When tested in anesthetized rats (Wistar rats), L-756867 inhibits L-692429 (100 μg/kg)-stimulated GH secretion in a dose-dependent manner. Complete inhibition is observed at an i.v. dose of 100 μg/kg of L-756867[1].
References
[1] Cheng K, et al. Inhibition of L-692,429-stimulated rat growth hormone release by a weak substance P antagonist: L-756,867. J Endocrinol. 1997 Jan;152(1):155-8. DOI:10.1677/joe.0.1520155
[2] Holst B, et al. Nonpeptide and peptide growth hormone secretagogues act both as ghrelin receptor agonist and as positive or negative allosteric modulators of ghrelin signaling. Mol Endocrinol. 2005 Sep;19(9):2400-11. DOI:10.1210/me.2005-0059
[3] Cunha SR, et al. Ghrelin and growth hormone (GH) secretagogues potentiate GH-releasing hormone (GHRH)-induced cyclic adenosine 3',5'-monophosphate production in cells expressing transfected GHRH and GH secretagogue receptors. Endocrinology. 2002 Dec;143(1 DOI:10.1210/en.2002-220670
L 692429 Preparation Products And Raw materials
Raw materials
Preparation Products
L 692429 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Jinan Yaoyan Pharmaceutical Co., Ltd. | jnyaoyan@163.com | China | 3057 | 58 | |
| Nanjing Meihao Pharmaceutical Technology Co., Ltd. | meitaochem@126.com | meitaochem@126.com | China | 19087 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Shanghai Dexuan Pharmaceutical Technology Co., Ltd | dexuanyiyao@126.com | dexuanyiyao@126.com | China | 9470 | 58 |
| JinOu Biomedical (Nanjing) Co., Ltd. | 13000000000 | jinoupharma@163.com | China | 11706 | 58 |
| Suzhou Meishi Biotechnology Co., Ltd. | 1173954148q | meishipharma@126.com | China | 20027 | 58 |
| Wuhan Jingkangen Biomedical Technology Co., Ltd | 13720134139 086-15871494362 13720134139 | orders@jknbiochem.com | China | 7284 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29873 | 58 |
