FATOSTATIN A
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- CAS号:
- 125256-00-0
- 英文名:
- Fatostatin A
- 英文别名:
- 125B11;2-(2-propylpyridin-4-yl)-4-(p-tolyl)thiazole;Pyridine, 4-[4-(4-methylphenyl)-2-thiazolyl]-2-propyl-;4-(4-methylphenyl)-2-(2-propylpyridin-4-yl)-1,3-thiazole;mice,125B11,prostate,cancer,Fatty Acid Synthase (FASN),gene,human,insulin-induced,Fatostatin,ob/ob,inhibit,expression,Golgi,Inhibitor,adipogenesis,SREBP-mediated
- 中文名:
- FATOSTATIN A
- 中文别名:
- 脂肪抑制素;化合物FATOSTATIN A;FATOSTATIN FREE BASE;2-(2-丙基吡啶-4-基)-4-(对甲苯基)噻唑
- CBNumber:
- CB92627880
- 分子式:
- C18H18N2S
- 分子量:
- 294.41
- MOL File:
- 125256-00-0.mol
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FATOSTATIN A化学性质
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沸点:
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474.3±55.0 °C(Predicted)
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密度:
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1.125±0.06 g/cm3(Predicted)
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储存条件:
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under inert gas (nitrogen or Argon) at 2-8°C
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溶解度:
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Soluble in DMSO (up to 25 mg/ml).
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形态:
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solid
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酸度系数(pKa):
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3.46±0.10(Predicted)
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颜色:
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Yellow
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稳定性:
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Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
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FATOSTATIN A性质、用途与生产工艺
Fatostatin (125B11) 是一种diarylthiazole的衍生物，是 Sterol regulatory element binding proteins (SREBPs) 活化的特异性抑制剂。Fatostatin 可结合SCAP (SREBP cleavage-activating protein)，并抑制SREBP的ER-Golgi易位。Fatostatin 可抑制癌细胞生长并增强癌细胞的凋亡。
Fatostatin (125B11) (0.1-1 μM; 3 days) inhibits the androgen-independent prostate cancer cell proliferation (IC
50
=0.1 μM) in an independent of the known IGF1-signaling pathway. Fatostatin inhibits insulin-induced adipogenesis of 3T3-L1 cells.
Fatostatin directly binds SCAP and blocks its ER-to-Golgi transport with IC
50
of 2.5 and 10 μM in mammalian cells.
Cell Proliferation Assay
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Cell Line:
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DU-145 cells
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Concentration:
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0.1, 1 μM
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Incubation Time:
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3 days
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Result:
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Impaired the IGF1-induced growth at an IC
50
of 0.1 μM.
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Fatostatin (125B11) (30 mg/kg; 150 μL; i.p. injection; daily for 28 days) reduces adiposity, ameliorated fatty liver by reducing triglyceride (TG) storage, and lowered hyperglycemia in
ob/ob
mice.
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Animal Model:
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Four-to-five-week-old homozygous male obese (
ob/ob
) mice (C57BL/6J)
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Dosage:
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30 mg/kg; 150 μL
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Administration:
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i.p. injection; daily for 28 days
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Result:
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Blocked increases in body weight, blood glucose, and hepatic fat accumulation in obese
ob/ob
mice, even under uncontrolled food intake.
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FATOSTATIN A
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | S9785 | FATOSTATIN A
Fatostatin | 125256-00-0 | 5mg | 795.2元 |
| 2024/04/30 | S9785 | Fatostatin | 125256-00-0 | 100mg | 5954.31元 |
125256-00-0, FATOSTATIN A 相关搜索:
- 药靶配体
- FATOSTATIN FREE BASE
- 化合物FATOSTATIN A
- 2-(2-丙基吡啶-4-基)-4-(对甲苯基)噻唑
- 脂肪抑制素
- 125256-00-0
- mice,125B11,prostate,cancer,Fatty Acid Synthase (FASN),gene,human,insulin-induced,Fatostatin,ob/ob,inhibit,expression,Golgi,Inhibitor,adipogenesis,SREBP-mediated
- 2-(2-propylpyridin-4-yl)-4-(p-tolyl)thiazole
- Pyridine, 4-[4-(4-methylphenyl)-2-thiazolyl]-2-propyl-
- 125B11
- 4-(4-methylphenyl)-2-(2-propylpyridin-4-yl)-1,3-thiazole