5-(Hydroxymethyl)-2'-deoxycytidine
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- CAS-Nr.
- 7226-77-9
- Englisch Name:
- 5-(Hydroxymethyl)-2'-deoxycytidine
- Synonyma:
- 5-hmdC;5-Hydroxymethyl-dC;5-hydroxy methyl-2'-dC;5-Hydroxymethyl-2'-deoxycytidine;4-(HydroxyMethyl)-2'-deoxycytidine;2'-deoxy-5-(hydroxyMethyl)cytidine;2'-Deoxy-5-(hydroxymethyl)cytidine>Cytidine, 2'-deoxy-5-(hydroxyMethyl)-;5-hydroxymethyldeoxycytidine monophosphate;4-Amino-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-(hydroxymethyl)pyrimidin-2(1H)-one
- CBNumber:
- CB01327931
- Summenformel:
- C10H15N3O5
- Molgewicht:
- 257.24
- MOL-Datei:
- 7226-77-9.mol
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5-(Hydroxymethyl)-2'-deoxycytidine Eigenschaften
- Schmelzpunkt:
- 205°C(lit.)
- Siedepunkt:
- 575.0±60.0 °C(Predicted)
- Dichte
- 1.480 g/cm3
- storage temp.
- Store at -20°C
- Löslichkeit
- DMF: 5 mg/ml; DMSO: 20 mg/ml; PBS (pH 7.2): 10 mg/ml
- Aggregatzustand
- powder to crystal
- pka
- 13.47±0.10(Predicted)
- Farbe
- White to Light yellow
- maximale Wellenlänge (λmax)
- 274nm(H2O)(lit.)
- InChI
- InChI=1S/C10H15N3O5/c11-9-5(3-14)2-13(10(17)12-9)8-1-6(16)7(4-15)18-8/h2,6-8,14-16H,1,3-4H2,(H2,11,12,17)/t6-,7+,8+/m0/s1
- InChIKey
- HMUOMFLFUUHUPE-XLPZGREQSA-N
- SMILES
- OC[C@H]1O[C@@H](N2C=C(CO)C(N)=NC2=O)C[C@@H]1O
- CAS Datenbank
- 7226-77-9
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P301+P312 |
BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P330 |
Mund ausspülen. |
| P501 |
Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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5-(Hydroxymethyl)-2'-deoxycytidine Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
DNA methylation occurs mainly at the 5’-position of cytosine rings (5-methylcytosine) and occurs almost exclusively in CpG islands. Another epigenetic modification in DNA has been recently identified that involves hydroxymethylation of this same base (5-hydroxymethylcytosine), which potentially offers another level of transcriptional control. 5-(Hydroxymethyl)-2’-deoxycytidine is a modified pyrimidine that is capable of producing interstrand cross-links in double-stranded DNA and has been used to quantify DNA hydroxymethylation levels in biological samples.
Biologische Funktion
5-(hydroxymethyl)-2'-deoxycytidine (5-hmdC), the oxidative product from 5- (methyl)-2'-deoxycytidine (5-mdC) by TET protein, plays critical roles in a variety of physiological processes such as DNA demethylation, cellular differentiation, and epigenetic regulation, etc. In addition, 5-hmdC has also been demonstrated as a potential biomarker reflecting the diagnosis and prognosis of multiple diseases. Some studies have reported that the level of 5-hmdC significantly decreases in diversified cancers, which suggests its important role in tumor formation and development. In 2009, breakthrough studies found that the 5-hmdC is not the unique oxidative product of 5-mdC. 5-(hydroxymethyl)-2'-deoxycytidine is a crucial intermediate product of the DNA demethylation pathway, which can act as potential biomarkers reflecting the diagnosis and prognosis in multiple tumors. 5-hmdC in human urine is in the form of single deoxynucleosides produced by DNA degradation or metabolism, which can avoid digestion. 5-hmdC has been identified in human urine[1].
5-(Hydroxymethyl)-2'-deoxycytidine Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
5-(Hydroxymethyl)-2'-deoxycytidine Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 71)Lieferanten
7226-77-9()Verwandte Suche:
- 5-hydroxymethyldeoxycytidine monophosphate
- 2'-deoxy-5-(hydroxyMethyl)cytidine
- 4-(HydroxyMethyl)-2'-deoxycytidine
- Cytidine, 2'-deoxy-5-(hydroxyMethyl)-
- 5-Hydroxymethyl-dC
- 5-hmdC
- 2'-Deoxy-5-(hydroxymethyl)cytidine>
- 5-hydroxy methyl-2'-dC
- 4-Amino-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-(hydroxymethyl)pyrimidin-2(1H)-one
- 5-Hydroxymethyl-2'-deoxycytidine
- 7226-77-9
- Bases & Related Reagents
- Carbohydrates & Derivatives
- Heterocycles
- Nucleotides
