chinoin 123

chinoin 123 Struktur
64405-40-9
CAS-Nr.
64405-40-9
Englisch Name:
chinoin 123
Synonyma:
chinoin 123;4H-Pyrido[1,2-a]pyrimidine-9-acetic acid, 3-(ethoxycarbonyl)-6,7,8,9-tetrahydro-6-methyl-4-oxo-;2-(3-(Ethoxycarbonyl)-6-methyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-9-yl)acetic acid
CBNumber:
CB01377097
Summenformel:
C14H18N2O5
Molgewicht:
294.3
MOL-Datei:
64405-40-9.mol

chinoin 123 Eigenschaften

Schmelzpunkt:
154-155 °C(Solv: ethanol (64-17-5))
Siedepunkt:
472.0±55.0 °C(Predicted)
Dichte
1.39±0.1 g/cm3(Predicted)
pka
4.45±0.10(Predicted)

Sicherheit

chinoin 123 Chemische Eigenschaften,Einsatz,Produktion Methoden

Originator

Acitemate ,Onbio Inc.

Manufacturing Process

23.6 g of 3-ethoxycarbonyl-7-methyl-4-oxo-6,7,8,9-tetrahydro-4Hpyrido[ 1,2a]pyrimidine and 10.0 g of glyoxylic acid monohydrate are reacted and the obtained 3-ethoxycarbonyl-7-methyl-9-carboxy(hydroxymethyl)-4- oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2a]pyrimidine is heated in 150 ml ethanol under stirring for 3 h. After cooling the crystals are filtered off and recrystallized from ethanol. Thus 3-ethoxycarbonyl-7-methyl-9- (carboxymethylene)-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2a]pyrimidine melting point 110°-112°C, is obtained (yield: 51%).
55.6 g of 3-ethoxycarbonyl-9-(carboxymethylene)-4-oxo-6,7,8,9-tetrahydro- 4H-pyrido[1,2a]pyrimidine are hydrogenated in 500 ml of ethanol in the presence of 20.0 g of 9% by weight Pd/C catalyst containing metal. When 1 mole of hydrogen has been used up, the catalyst is removed from the reaction mixture by filtration and the solution is evaporated under reduced pressure. The 3-ethoxycarbonyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidine-9- acetic acid is obtained (yield: 57%), melting point 156°-157°C (recrystallized from ethanol).

Therapeutic Function

Platelet aggregation inhibitor, Antihyperlipidemic

chinoin 123 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


chinoin 123 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 2)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hangzhou MolCore BioPharmatech Co.,Ltd.
+86-057181025280; +8617767106207
sales@molcore.com China 49739 58
TargetMol Chemicals Inc. 15002134094
marketing@targetmol.cn China 16377 58

64405-40-9()Verwandte Suche:


  • chinoin 123
  • 4H-Pyrido[1,2-a]pyrimidine-9-acetic acid, 3-(ethoxycarbonyl)-6,7,8,9-tetrahydro-6-methyl-4-oxo-
  • 2-(3-(Ethoxycarbonyl)-6-methyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-9-yl)acetic acid
  • 64405-40-9
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