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Danoprevir

Danoprevir Struktur
850876-88-9
CAS-Nr.
850876-88-9
Englisch Name:
Danoprevir
Synonyma:
Danoprevir;RG7227;Intepirdine;R7227;CS-64;RG72277;ITMN-191;RO5190591;Danpprevir;Danoprevir, >=98%
CBNumber:
CB02504568
Summenformel:
C35H46FN5O9S
Molgewicht:
731.83
MOL-Datei:
850876-88-9.mol
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Danoprevir Eigenschaften

Schmelzpunkt:
>165°C (dec.)
Dichte
1.41
storage temp. 
-20°C Freezer
Löslichkeit
Acetone (Slightly), DMSO (Slightly), Methanol (Slightly)
Aggregatzustand
Solid
pka
4.43±0.60(Predicted)
Farbe
White to Pale Beige
InChIKey
ZVTDLPBHTSMEJZ-AIYSODCISA-N
SMILES
C1C2=C(C(F)=CC=C2)CN1C(O[C@H]1CN2C(=O)[C@@H](NC(OC(C)(C)C)=O)CCCCCC=C[C@]3([H])C[C@@]3(C(NS(C3CC3)(=O)=O)=O)NC(=O)[C@]2([H])C1)=O |t:33|
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
Sicherheit
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

Danoprevir Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Danoprevir is an orally bioavailable inhibitor of hepatitis C virus (HCV) nonstructural protein 3/4A (NS3/4A; IC50 = 1 nM), a serine protease essential for HCV replication. It is selective for NS3/4A over a panel of 53 proteases at a concentration of 10 μM. Danoprevir inhibits replication of the HCV genotypes 1a, 1b, 4, 5, and 6 (IC50s = 0.2-0.4 nM) as well as 2b and 3a (IC50s = 1.6 and 3.5 nM, respectively) in vitro. It also reduces the number of HCV genotype 1b replicons in Huh-7 cells (EC50 = 1.8 nM).

Verwenden

Danoprevir is a selective and potent inhibitor of Hepatitis C virus.

Danoprevir Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Cyclopropanesulfonamide

Downstream Produkte

Danoprevir Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 102)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Wuhan Topule Biopharmaceutical Co., Ltd
+8618327326525
 masar@topule.com China 8474 58
Biochempartner 		0086-13720134139
candy@biochempartner.com CHINA 967 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427
 sales@conier.com China 47465 58
Career Henan Chemica Co 		+86-0371-86658258 15093356674;
 laboratory@coreychem.com China 30255 58
Baoji Guokang Bio-Technology Co., Ltd. 		0917-3909592 13892490616
 gksales1@gk-bio.com China 9339 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471
 sales@sarms4muscle.com China 10523 58
InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6393 58
TargetMol Chemicals Inc. 		+1-781-999-5354
support@targetmol.com United States 19973 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054
 trendseenbio@gmail.com China 11681 58
LEAPCHEM CO., LTD. 		+86-852-30606658
market18@leapchem.com China 43348 58
  • RG7227, ITMN-191, RO5190591
  • 4-Fluoro-1,3-dihydro-2H-isoindole-2-carboxylic acid (2R,6S,13aS,14aR,16aS)-14a-[[(cyclopropylsulfonyl)amino]carbonyl]-6-[[(1,1-dimethylethoxy)carbonyl]amino]-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydro-5,16-dioxocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-2-yl ester
  • ITMN-191
  • Danoprevir(ITMN-191)
  • 2H-Isoindole-2-carboxylic acid, 4-fluoro-1,3-dihydro-, (2R,6S,13aS,14aR,16aS)-14a-[[(cyclopropylsulfonyl)amino]carbonyl]-6-[[(1,1-dimethylethoxy)carbonyl]amino]-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydro-5,16-dioxocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-2-yl ester
  • dimethylethoxy)carbonyl]amino]-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydro-5,16-dioxocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-2-yl ester Danoprevir (ITMN-191)
  • Danoprevir, >=98%
  • Itmn-191 Danoprevir
  • (2R,6S,13aS,14aR,16aS,E)-6-((tert-butoxycarbonyl)aMino)-14a-((cyclopropylsulfonyl)carbaMoyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-2-yl 4-fluoroisoindoline-2-carboxylate
  • R7227
  • RO5190591
  • Danoprevir (RG7227)
  • Danoprevir(ITMN-191, RG7227)
  • Danoprevir - ITMN 191 | RG 7227 | R 7227
  • 2H-Isoindole-2-carboxylic acid, 4-fluoro-1,3-dihydro-, (2R,6S,13aS,14aR,16aS)-14a-[[(cyclopropylsulfonyl)amino]carbonyl]-6-[[(1,1-dimethylethoxy)carbonyl]amino]-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydro-5,16-dio
  • CS-64
  • ITMN-191; R7227; RO5190591; RG7227;ITMN191;ITMN 191
  • (2R,6S,13aS,14aR,16aS,)-6-((tert-Butoxycarbonyl)amino)-14a-((cyclopropylsulfonyl)carbamoyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-2-yl 4-fluoroisoindoline-2-carboxylate
  • RG72277
  • (2R,6S,13aS,14aR,16aS,Z)-6-((tert-butoxycarbonyl)amino)-14a-((cyclopropylsulfonyl)carbamoyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-2-yl 4-fluoroisoindoline-2-carboxylate
  • Danpprevir
  • Danoprevir ( ITMN191, R7227
  • Intepirdine
  • RG7227
  • Danoprevir
  • Danoprevir ITMN-191 Selleck HCV Protease inhibitor
  • Danoprevir(ITMN-191)/RG7227,RO5190591
  • 850876-88-9
  • Inhibitor
  • Inhibitors
  • Coronavirus
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