GlyT2-IN-1

448947-81-7

CAS-Nr.: 448947-81-7

Englisch Name:: GlyT2-IN-1

Synonyma:: Yoda 1;CS-2063;GlyT2-IN-1;GlyT2-IN-1(YODA 1);Yoda1 >=98% (HPLC);Yoda 1 (GlyT2-IN-1);2-((2,6-Dichlorobenzyl)thio)-5-(pyrazin-2-yl)-1,3,4-thiadiazole;2-[5-[[(2,6-Dichlorophenyl)methyl]thio]-1,3,4-thiadiazol-2-yl]pyrazine;Pyrazine, 2-[5-[[(2,6-dichlorophenyl)methyl]thio]-1,3,4-thiadiazol-2-yl]-;KcsA,Potassium Channel,Akt,Yoda-1,PKB,Inhibitor,A431 cells,Yoda 1,HCAECs,inhibit,Protein kinase B,ERK,Piezo1,Extracellular signal regulated kinases,Endothelial cells,ERK1/2,Piezo Channel,Yoda1

CBNumber:: CB03048654

Summenformel:: C13H8Cl2N4S2

Molgewicht:: 355.27

MOL-Datei:: 448947-81-7.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 74

GlyT2-IN-1 Eigenschaften

Schmelzpunkt:: 136 - 138°C

Siedepunkt:: 538.4±60.0 °C(Predicted)

Dichte: 1.58±0.1 g/cm3(Predicted)

storage temp.: 2-8°C

Löslichkeit: DMSO (Slightly), Methanol (Very Slightly)

pka: -1.32±0.10(Predicted)

Aggregatzustand: powder

Farbe: white to beige

Sicherheit

Risiko- und Sicherheitserklärung
Gefahreninformationscode (GHS)

HS Code	2934999090

Bildanzeige (GHS)

Alarmwort

Warnung

Gefahrenhinweise

Code	Gefahrenhinweise	Gefahrenklasse	Abteilung	Alarmwort	Symbol	P-Code
H302	Gesundheitsschädlich bei Verschlucken.	Akute Toxizität oral	Kategorie 4	Warnung	src="/GHS07.jpg" width="20" height="20" />	P264, P270, P301+P312, P330, P501

Sicherheit

GlyT2-IN-1 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Yoda 1 is a piezo1 channel activator, sensitizes piezo1 to activation by pressure and slows the inactivation phase of transient currents in human embryonic kidney (HEK) cells.

Allgemeine Beschreibung

Yoda1 is a novel synthetic small molecule developed to study the kinetics, regulation and function of the cation channel Piezo-type mechanosensitive ion channel component 1 (Piezo1).

Biochem/physiol Actions

Yoda1 is a specific activator of mouse and human cation channel Piezo1, a mechanosensitive channel that mediates Ca2+ influx on mechanical activation and has been linked to a role in blood vessel development. Yoda1 stabilizes the Piezo1 open channel. In red blood cells, this was followed by downstream activation of the KCa3.1 Gardos channel with resultant calcium influx and potassium and water efflux, causing shrinkage of the cells. Yoda1 is the first Piezo1 agonist, giving the first evidence of non-mechanical activation of a Piezo channel.

GlyT2-IN-1 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

GlyT2-IN-1 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 74)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32836	60
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30250	58
Shanxi Xuanran Import and Export Trade Co., Ltd.	+8617735180244	mike_yan@xuanranglobal.com	CHINA	4022	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8474	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57511	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131980	58
Haoyuan Chemexpress Co., Ltd.	021-58950125	info@chemexpress.com	China	7553	61

GlyT2-IN-1
Yoda 1
GlyT2-IN-1(YODA 1)
Yoda 1 (GlyT2-IN-1)
Yoda1 >=98% (HPLC)
Pyrazine, 2-[5-[[(2,6-dichlorophenyl)methyl]thio]-1,3,4-thiadiazol-2-yl]-
2-[5-[[(2,6-Dichlorophenyl)methyl]thio]-1,3,4-thiadiazol-2-yl]pyrazine
CS-2063
2-((2,6-Dichlorobenzyl)thio)-5-(pyrazin-2-yl)-1,3,4-thiadiazole
KcsA,Potassium Channel,Akt,Yoda-1,PKB,Inhibitor,A431 cells,Yoda 1,HCAECs,inhibit,Protein kinase B,ERK,Piezo1,Extracellular signal regulated kinases,Endothelial cells,ERK1/2,Piezo Channel,Yoda1
448947-81-7
C13H8Cl2N4S2