Alfaxalone
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- CAS-Nr.
- 23930-19-0
- Englisch Name:
- Alfaxalone
- Synonyma:
- gr2/234;ALFAXALONE;ALPHAXALONE;Alphaxolone;ALFAXALONE USP/EP/BP;5A-pregnan-3A-ol-11,20-dione;5α-Pregnan-3α-ol-11,20-dione;3-hydroxypregnane-11,20-dione;5α-PREGNAN-3α-OL-11, 20-DIONE;3α-Hydroxy-5α-pregnane-11,12-dione
- CBNumber:
- CB0756297
- Summenformel:
- C21H32O3
- Molgewicht:
- 332.48
- MOL-Datei:
- 23930-19-0.mol
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Alfaxalone Eigenschaften
- Schmelzpunkt:
- 172-174°
- alpha
- D26 +113.4° (c = 1.2 in chloroform).
- Siedepunkt:
- 409.59°C (rough estimate)
- Dichte
- 1.0834 (rough estimate)
- Brechungsindex
- 1.5192 (estimate)
- storage temp.
- Store at RT
- Löslichkeit
- chloroform: ≥5 mg/mL, clear, colorless
- Aggregatzustand
- powder
- pka
- 15.05±0.70(Predicted)
- Farbe
- white
- InChI
- InChI=1/C21H32O3/c1-12(22)16-6-7-17-15-5-4-13-10-14(23)8-9-20(13,2)19(15)18(24)11-21(16,17)3/h13-17,19,23H,4-11H2,1-3H3/t13-,14+,15-,16+,17-,19+,20-,21+/s3
- InChIKey
- DUHUCHOQIDJXAT-YYJIQYHHNA-N
- SMILES
- [C@]12([H])C(=O)C[C@]3(C)[C@H](CC[C@@]3([H])[C@]1([H])CC[C@@]1([H])C[C@H](O)CC[C@]21C)C(=O)C |&1:0,5,7,10,12,16,19,23,r|
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
Xn |
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| R-Sätze: |
22 |
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| S-Sätze: |
22-36 |
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| RIDADR |
UN 2811 6.1/PG 3 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
TU4157800 |
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| Toxizität |
LD50 i.v. in mice: 43 mg/kg (Al-Khawashki) |
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| Bildanzeige (GHS) |
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H301 |
Giftig bei Verschlucken. |
Akute Toxizität oral |
Kategorie 3 |
Achtung |
![GHS hazard pictograms]() src="/GHS06.jpg" width="20" height="20" /> |
P264, P270, P301+P310, P321, P330,P405, P501 |
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| Sicherheit |
| P301+P310 |
BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
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Alfaxalone Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Verwenden
Anesthetic;nociception blocker
Biologische Aktivität
A neurosteroid anesthetic that directly activates and potentiates GABA A receptor-activated membrane current (I GABA ). Efficacy but not potency is determined by the alpha subunit of the receptor (EC 50 values are 1.4, 1.8, 2.1, 2.4 and 2.5 μ M for α 1 β 1 γ 3, α 1 β 1 γ 1, β 1 γ 1, α 2 β 1 γ 2L and α 1 β 1 γ 2L isoforms respectively).
Mechanism of action
Alfaxalone's mechanism of action is chloride ion modulation associated with interaction with the neuronal membrane GABA A receptor[1].
Alfaxalone Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Alfaxalone Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 60)Lieferanten
23930-19-0()Verwandte Suche:
- 3ALPHA-HYDROXY-5ALPHA-PREGNANE-11,20-DIONE
- 3-HYDROXY-5ALPHA-PREGNANE-11,20-DIONE
- 5ALPHA-PREGNAN-3ALPHA-OL-11,20-DIONE
- ALFAXALONE
- ALPHAXALONE
- (3-alpha,5-alpha)-3-hydroxypregnane-11,20-dione
- 20-dione,3-alpha-hydroxy-5-alpha-pregnane-1
- 20-dione,3-hydroxy-,(3-alpha,5-alpha)-pregnane-1
- 3-hydroxypregnane-11,20-dione
- gr2/234
- 5A-pregnan-3A-ol-11,20-dione
- Pregnane-11,20-dione, 3-hydroxy-, (3.alpha.,5.alpha.)-
- 3-Hydroxy-5α-pregnane-11,20-dione, Alfaxalone
- 5α-Pregnan-3α-ol-11,20-dione
- 3α-Hydroxy-5α-pregnane-11,12-dione
- (3α,5α)-3-Hydroxypregnane-11,20-dione
- Pregnane-11,20-dione,3-hydroxy-, (3a,5a)-
- Alphaxolone
- Pregnane-11,20-dione, 3-hydroxy-, (3α,5α)-
- (3R,5S,8S,9S,10S,13S,14S,17S)-17-acetyl-3-hydroxy-10,13-dimethyltetradecahydro-1H-cyclopenta[a]phenanthren-11(2H)-one
- ALFAXALONE USP/EP/BP
- (3α,5α)-3-Hydroxypregnane-11,20-dione
- 5α-PREGNAN-3α-OL-11, 20-DIONE
- 23930-19-0
- GABA and Glycine Receptor Modulators
- Ion Channels
- Ligand-Gated Ion Channels
- BioChemical
- Cell Signaling and Neuroscience
- Cell Biology
