L-2-(2-Amino-1,4,5,6-tetrahydro-4-pyrimidinyl)-N-[[(1-carboxy-3-methylbutyl)amino]carbonyl]glycyl-N1-(1-methyl-2-oxoethyl)-L-glutamamid, stereoisomer
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- CAS-Nr.
- 51798-45-9
- Bezeichnung:
- L-2-(2-Amino-1,4,5,6-tetrahydro-4-pyrimidinyl)-N-[[(1-carboxy-3-methylbutyl)amino]carbonyl]glycyl-N1-(1-methyl-2-oxoethyl)-L-glutamamid, stereoisomer
- Englisch Name:
- ELASTATINAL
- Synonyma:
- ELASTATINAL;AIDS-006470;Leu-co-cpd-Gln-Ala-h;ELASTATINAL USP/EP/BP;elastatinal from microbial source;N-[-N-ALPHA-CARBONYL-CPD-GLN-ALA-AL]-LEU;l-glutamamide,l-2-(2-amino-1,4,5,6-tetrahydro-4-pyrimidinyl-n-(((1-carboxy-3-m;N-[(S)-1-CARBOXYISOPENTYL]CARBAMOYL-ALPHA-[2-IMINOHEXAHYDRO-4(S)-PYRIMIDYL-(S)-GLYCYL-(S)-GLUTAMINYL-(S)-ALANINAL];Nα-[2-(2-Amino-1,4,5,6-tetrahydropyrimidin-4-yl)-N-[[(1-carboxy-3-methylbutyl)amino]carbonyl]-L-glycyl]-N1-(1-methyl-2-oxoethyl)-L-glutaminamide;L-Glutamamide, (2S)-2-(4S)-2-amino-1,4,5,6-tetrahydro-4-pyrimidinyl-N-(1S)-1-carboxy-3-methylbutylaminocarbonylglycyl-N1-(1S)-1-methyl-2-oxoethyl-
- CBNumber:
- CB1249000
- Summenformel:
- C21H36N8O7
- Molgewicht:
- 512.56
- MOL-Datei:
- 51798-45-9.mol
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L-2-(2-Amino-1,4,5,6-tetrahydro-4-pyrimidinyl)-N-[[(1-carboxy-3-methylbutyl)amino]carbonyl]glycyl-N1-(1-methyl-2-oxoethyl)-L-glutamamid, stereoisomer Eigenschaften
- storage temp.
- -20°C
- Löslichkeit
- H2O: 20 mg/mL, clear, yellow
- Aggregatzustand
- Yellow solid.
- Farbe
- off-white
- BRN
- 873543
- Stabilität:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.
Sicherheit
| S-Sätze: |
22-24/25 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
LZ9600000 |
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| F |
10 |
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L-2-(2-Amino-1,4,5,6-tetrahydro-4-pyrimidinyl)-N-[[(1-carboxy-3-methylbutyl)amino]carbonyl]glycyl-N1-(1-methyl-2-oxoethyl)-L-glutamamid, stereoisomer Chemische Eigenschaften,Einsatz,Produktion Methoden
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Beschreibung
Elastatinal is a potent inhibitor of pancreatic elastase (K
i = 240 nM) that is produced by various species of
Actinomycetes. It more strongly inhibits pancreatic elastase
versus the leukocyte-derived enzyme. Elastatinal reduces electrophoretic mobilities of 2A proteinases from poliovirus and human rhinovirus 14 in a dose-dependent manner, indicating substrate recognition by 2A proteinases is similar to that of pancreatic elastases. It can also inhibit elastase-like protease collagenolytic protease from
C. maenas digestive glands.
Verwenden
Elastatinal is an elastase inhibitor.
Biochem/physiol Actions
Potent, irreversible elastase inhibitor. Elastatinal is a much stronger inhibitor of elastase from pancreas than from leucocytes.
L-2-(2-Amino-1,4,5,6-tetrahydro-4-pyrimidinyl)-N-[[(1-carboxy-3-methylbutyl)amino]carbonyl]glycyl-N1-(1-methyl-2-oxoethyl)-L-glutamamid, stereoisomer Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
L-2-(2-Amino-1,4,5,6-tetrahydro-4-pyrimidinyl)-N-[[(1-carboxy-3-methylbutyl)amino]carbonyl]glycyl-N1-(1-methyl-2-oxoethyl)-L-glutamamid, stereoisomer Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 77)Lieferanten
51798-45-9(L-2-(2-Amino-1,4,5,6-tetrahydro-4-pyrimidinyl)-N-[[(1-carboxy-3-methylbutyl)amino]carbonyl]glycyl-N1-(1-methyl-2-oxoethyl)-L-glutamamid, stereoisomer)Verwandte Suche:
- N-[-N-ALPHA-CARBONYL-CPD-GLN-ALA-AL]-LEU
- elastatinal from microbial source
- L-2-(2-amino-1,4,5,6-tetrahydro-4-pyrimidinyl)-N-[[(1-carboxy-3-methylbutyl)amino]carbonyl]glycyl-N1-(1-methyl-2-oxoethyl)-L-glutamamide, stereoisomer
- Leu-co-cpd-Gln-Ala-h
- L-Glutamamide, (2S)-2-(4S)-2-amino-1,4,5,6-tetrahydro-4-pyrimidinyl-N-(1S)-1-carboxy-3-methylbutylaminocarbonylglycyl-N1-(1S)-1-methyl-2-oxoethyl-
- (2s)-2-[(4s)-2-amino-1,4,5,6-tetrahydro4-pyrimidinyl]-n-[[[(1s)-1-carboxy-3-methylbutyl]amino]carbonyl]glycyl-n1-[(1s)-1-methyl-2-oxoethyl-l-glutamamide
- AIDS-006470
- Nα-[2-(2-Amino-1,4,5,6-tetrahydropyrimidin-4-yl)-N-[[(1-carboxy-3-methylbutyl)amino]carbonyl]-L-glycyl]-N1-(1-methyl-2-oxoethyl)-L-glutaminamide
- (2S)-2-[(4S)-2-Amino-3,4,5,6-tetrahydro-4-pyrimidinyl]-N-[[[(1S)-1-carboxy-3-methylbutyl]amino]carbonyl]glycyl-N1-[(1S)-1-methyl-2-oxoethyl]-L-glutamamide
- l-glutamamide,l-2-(2-amino-1,4,5,6-tetrahydro-4-pyrimidinyl-n-(((1-carboxy-3-m
- ELASTATINAL
- N-[(S)-1-CARBOXYISOPENTYL]CARBAMOYL-ALPHA-[2-IMINOHEXAHYDRO-4(S)-PYRIMIDYL-(S)-GLYCYL-(S)-GLUTAMINYL-(S)-ALANINAL]
- L-Glutamamide, (2S)-2-[(4S)-2-amino-3,4,5,6-tetrahydro-4-pyrimidinyl]-N-[[[(1S)-1-carboxy-3-methylbutyl]amino]carbonyl]glycyl-N1-[(1S)-1-methyl-2-oxoethyl]-
- ELASTATINAL USP/EP/BP
- (2S)-2-[[(1S)-2-[[(2S)-5-amino-1,5-dioxo-1-[[(2S)-1-oxopropan-2-yl]amino]pentan-2-yl]amino]-1-(2-amino-1,4,5,6-tetrahydropyrimidin-6-yl)-2-oxoethyl]carbamoylamino]-4-methylpentanoic acid
- 51798-45-9
- C21H36N8O7
- C21H36N8O6
- P to Q
- Plasmin
- Organic Covalent Modifiers
- Enzyme Inhibitors
- Enzyme Inhibitors by Enzyme
- Enzyme Inhibitors by Type
- Enzymes, Inhibitors, and Substrates
- BioChemical
- Biochemicals and Reagents
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- E
- Enzyme Inhibitors
- Enzyme Inhibitors by Enzyme
