SID 24769845

949898-66-2

CAS-Nr.: 949898-66-2

Englisch Name:: SID 24769845

Synonyma:: AS-136A;SID 24769845;CID 16122506;2-methyl-N-(4-piperidin-1-ylsulfonylphenyl)-5-(trifluoromethyl)pyrazole-3-carboxamide;1-Methyl-N-[4-(1-piperidinylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide;1H-Pyrazole-5-carboxamide, 1-methyl-N-[4-(1-piperidinylsulfonyl)phenyl]-3-(trifluoromethyl)-

CBNumber:: CB12750959

Summenformel:: C17H19F3N4O3S

Molgewicht:: 416.42

MOL-Datei:: 949898-66-2.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 3

SID 24769845 Eigenschaften

Dichte: 1.47±0.1 g/cm3(Predicted)

storage temp.: 2-8°C

Löslichkeit: DMSO: >10mg/mL

Aggregatzustand: powder

pka: 12.28±0.70(Predicted)

Farbe: white to off-white

Sicherheit

Risiko- und Sicherheitserklärung
Gefahreninformationscode (GHS)

Kennzeichnung gefährlicher	Xn
R-Sätze:	22-36
S-Sätze:	26
WGK Germany	3

Bildanzeige (GHS)

Alarmwort

Warnung

Gefahrenhinweise

Code	Gefahrenhinweise	Gefahrenklasse	Abteilung	Alarmwort	Symbol	P-Code
H302	Gesundheitsschädlich bei Verschlucken.	Akute Toxizität oral	Kategorie 4	Warnung	src="/GHS07.jpg" width="20" height="20" />	P264, P270, P301+P312, P330, P501
H319	Verursacht schwere Augenreizung.	Schwere Augenreizung	Kategorie 2	Warnung	src="/GHS07.jpg" width="20" height="20" />	P264, P280, P305+P351+P338,P337+P313P

Sicherheit

P305+P351+P338

BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

SID 24769845 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

AS-136A is a small molecule developed as part of the NIH Probes effort. AS-136A is a potent measles virus (MeV) RNA-dependent RNA polymerase (RdRp) inhibitor. AS-136A is very stable, decreases virus titer after 24 hours in physiological conditions, and serves as a positive control in MeV inhibitory assays.

Biochem/physiol Actions

AS-136A is a potent measles virus RdRp inhibitor. Measles virus (MV) is a member of the paramyxovirus family. Ribavirin (R9644) is the only drug available for treatment of paramyxoviruses, and it has limited efficacy against MV. A series of small molecules has been developed to inhibit viral RNA-dependent RNA polymerase (RdRp), a protein vital to infection leading to the development of AS-136A, a very potent RdRp inhibitor. AS-136A has high stability and continues to decrease virus titer after 24 hours in physiologic conditions. AS-136A is now used as a positive control in experiments assaying MV inhibition. This compound is a product of the NIH Probes effort, also known as SID 24769845.

SID 24769845 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

SID 24769845 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 3)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24131	58

1-Methyl-N-[4-(1-piperidinylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide
AS-136A
CID 16122506
SID 24769845
2-methyl-N-(4-piperidin-1-ylsulfonylphenyl)-5-(trifluoromethyl)pyrazole-3-carboxamide
1H-Pyrazole-5-carboxamide, 1-methyl-N-[4-(1-piperidinylsulfonyl)phenyl]-3-(trifluoromethyl)-
949898-66-2
C17H19F3N4O3S