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SID 24769845

SID 24769845 Structure
SID 24769845 structure
CAS No.
949898-66-2
Chemical Name:
SID 24769845
Synonyms
AS-136A;SID 24769845;CID 16122506;2-methyl-N-(4-piperidin-1-ylsulfonylphenyl)-5-(trifluoromethyl)pyrazole-3-carboxamide;1-Methyl-N-[4-(1-piperidinylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide;1H-Pyrazole-5-carboxamide, 1-methyl-N-[4-(1-piperidinylsulfonyl)phenyl]-3-(trifluoromethyl)-
CBNumber:
CB12750959
Molecular Formula:
C17H19F3N4O3S
Molecular Weight:
416.42
MDL Number:
MFCD16875415
MOL File:
949898-66-2.mol
MSDS File:
SDS
Last updated:2023-04-23 13:52:06
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SID 24769845 Properties

Density 1.47±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: >10mg/mL
form powder
pka 12.28±0.70(Predicted)
color white to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H319
Precautionary statements  P305+P351+P338
Hazard Codes  Xn
Risk Statements  22-36
Safety Statements  26
WGK Germany  3

SID 24769845 price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
American Custom Chemicals Corporation INB0000944 AS-136A 95.00% 949898-66-2 5MG $697.51 2021-12-16 Buy
American Custom Chemicals Corporation INB0000944 AS-136A 95.00% 949898-66-2 25MG $1025.99 2021-12-16 Buy
Product number Packaging Price Buy
INB0000944 5MG $697.51 Buy
INB0000944 25MG $1025.99 Buy

SID 24769845 Chemical Properties,Uses,Production

Uses

AS-136A is a small molecule developed as part of the NIH Probes effort. AS-136A is a potent measles virus (MeV) RNA-dependent RNA polymerase (RdRp) inhibitor. AS-136A is very stable, decreases virus titer after 24 hours in physiological conditions, and serves as a positive control in MeV inhibitory assays.

Biochem/physiol Actions

AS-136A is a potent measles virus RdRp inhibitor. Measles virus (MV) is a member of the paramyxovirus family. Ribavirin (R9644) is the only drug available for treatment of paramyxoviruses, and it has limited efficacy against MV. A series of small molecules has been developed to inhibit viral RNA-dependent RNA polymerase (RdRp), a protein vital to infection leading to the development of AS-136A, a very potent RdRp inhibitor. AS-136A has high stability and continues to decrease virus titer after 24 hours in physiologic conditions. AS-136A is now used as a positive control in experiments assaying MV inhibition. This compound is a product of the NIH Probes effort, also known as SID 24769845.

SID 24769845 Preparation Products And Raw materials

Raw materials

Preparation Products

SID 24769845 Suppliers

Global( 3)Suppliers
Supplier Tel Email Country ProdList Advantage
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 16377 58
Supplier Advantage
Sigma-Aldrich 80
TargetMol Chemicals Inc. 58
1-Methyl-N-[4-(1-piperidinylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide AS-136A CID 16122506 SID 24769845 2-methyl-N-(4-piperidin-1-ylsulfonylphenyl)-5-(trifluoromethyl)pyrazole-3-carboxamide 1H-Pyrazole-5-carboxamide, 1-methyl-N-[4-(1-piperidinylsulfonyl)phenyl]-3-(trifluoromethyl)- 949898-66-2 C17H19F3N4O3S