4'-HYDROXYCHALCONE
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- CAS-Nr.
- 2657-25-2
- Englisch Name:
- 4'-HYDROXYCHALCONE
- Synonyma:
- 4'-HYDROXYCHALCONE;4'-Hydroxychalcone;HYDROXYCHALCONE, 4'-;4'-Hydroxychalcone98%;4'-Hydroxychalcone>4'-Hydroxychalcone 98%;4'-Hydroxychalcone,97%;HYDROXYCHALCONE, 4-(RG);4'-Hydroxychalcone, ≥ 95.0%;2-BENZAL-4'-HYDROXYACETOPHENONE
- CBNumber:
- CB1342383
- Summenformel:
- C15H12O2
- Molgewicht:
- 224.25
- MOL-Datei:
- 2657-25-2.mol
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4'-HYDROXYCHALCONE Eigenschaften
- Schmelzpunkt:
- 174-178 °C
- Siedepunkt:
- 419.6±45.0 °C(Predicted)
- Dichte
- 1.191±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- Löslichkeit
- DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH 7.2) (1:4): 0.2 mg/ml
- Aggregatzustand
- powder to crystal
- pka
- 7.72±0.15(Predicted)
- Farbe
- Light orange to Yellow to Green
- BRN
- 2049150
- InChIKey
- UAHGNXFYLAJDIN-IZZDOVSWSA-N
- LogP
- 3.650 (est)
- CAS Datenbank
- 2657-25-2(CAS DataBase Reference)
4'-HYDROXYCHALCONE Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Beschreibung
4''-hydroxy Chalcone is a chalcone metabolite with diverse biological activities. It is formed when chalcone is metabolized by the cytochrome (CYP) P450 isoform CYP1A1 or CYP2C6. 4''-hydroxy Chalcone is estrogenic in MCF-7 cells and is cytotoxic at concentrations higher than 100 nM. It inhibits TNF-α-induced NF-κB signaling and the trypsin-, chymotrypsin-, and caspase-like proteolytic activities of the 26S proteasome in K562 cells in a dose-dependent manner. 4''-hydroxy Chalcone reduces growth of K562, U937, and Jurkat cancer cell lines in a dose-dependent manner without effecting viability of peripheral blood mononuclear cells (PBMCs). It also inhibits glutathione reductase (GSH-RD; IC
50 = 47.3 μM)
in vitro in a reversible and non-competitive manner.
Chemische Eigenschaften
yellow-cream powder
Verwenden
antineoplastic,
Definition
ChEBI: A member of the class of chalcones that is trans-chalcone substituted by a hydroxy group at position 4'.
4'-HYDROXYCHALCONE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
4'-HYDROXYCHALCONE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 152)Lieferanten
2657-25-2()Verwandte Suche:
5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-benzopyron
7-Hydroxy-2-phenyl-4-benzopyron
1-[4-[[6-O-(6-Desoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2-hydroxy-6-methoxyphenyl]-3-(3-hydroxy-4-methoxyphenyl)prop-2-en-1-on
2',3,4',5,7-Pentahydroxyflavon
Rutosid
3,3',4,4',5',7-Hexahydro-2-phenyl-4H-chromen-4-on
(E)-2',4,4'-Trihydroxy-3-methoxychalkon
Quercetin
5,7-Dihydroxy-2-phenyl-4H-benzo[b]pyran-4-on
3,5,7-Trihydroxy-2-phenyl-4-benzopyron
α-Styryl-p-anisylketon
7,8-Dihydroxy-2-phenyl-4-benzopyron
Diosmin
2,4,4'-Trimethoxychalkon
2'-Hydroxychalkon
2-Hydroxychalkon
(E)-2'-Hydroxychalkon
(E)-Chalkon
- 2-Benzal-4'-hydroxyacetophenone
2-Benzylidene-4'-hydroxyacetophenone
- 1-(4-Hydroxyphenyl)-3-phenyl-2-propen-1-one
- 1-(p-Hydroxyphenyl)-3-phenyl-2-propene-1-one
- 4'-Hydroxychalcone,97%
- 4'-Hydroxychalcone 98%
- HYDROXYCHALCONE, 4-(RG)
- 4'-Hydroxychalcone98%
- HYDROXYCHALCONE, 4'-
- BENZYLIDENE-(4-HYDROXYACETOPHENONE)
- BENZYLIDENE-4'-HYDROXYACETOPHENONE
- 4'-HYDROXYCHALCONE
- 2-BENZAL-4'-HYDROXYACETOPHENONE
- 2-BENZYLIDENE-4'-HYDROXYACETOPHENONE
- (E)-1-(4-hydroxyphenyl)-3-phenylprop-2-en-1-one
- 1-(4-Hydroxyphenyl)-3-phenylprop-2-en-1-one, 4-Cinnamoylphenol
- (E)-1-(4-hydroxyphenyl)-3-phenyl-2-propen-1-one
- 4'-Hydroxychalcone>
- 2-Propen-1-one, 1-(4-hydroxyphenyl)-3-phenyl-
- 4'-Hydroxychalcone, ≥ 95.0%
- 4'-Hydroxychalcone
- 2657-25-2
- C15H12O2
- Flavonoids
- Chalcones
- Biochemistry
- Flavonoids
