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PAI-1 Produkt Beschreibung

PAI-1 Struktur
CAS-Nr.
Englisch Name:
PAI-1
Synonyma:
PAI-1;ARMAPE;PAI-1, RAT;MOUSE PAI-1;PAI-1, MOUSE;PAI-1, HUMAN;PAI-1, MUTANT, MOUSE;PLASMINOGEN ACTIVATOR INHIBITOR 1;PLASMINOGEN ACTIVATOR INHIBITOR-1, RAT;MOUSE PLASMINOGEN ACTIVATOR INHIBITOR-1
CBNumber:
CB1438644
Summenformel:
C27H47N9O9S
Molgewicht:
673.78
MOL-Datei:
Mol file

PAI-1 Eigenschaften

Sicherheit

PAI-1 Chemische Eigenschaften,Einsatz,Produktion Methoden

Enzyminhibitor

This 402-residue serine protease inhibitor, or serpin (MW = 45074 g/mol; Abbreviation: PAI-1) binds to and inhibits plasminogen activators-tissuetype plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA). This inhibition reduces plasmin production and suppresses dissolution of fibrin clots. Elevated PAI-1 levels correlate with an increased cardiovascular disease risk, a behavior that has also been linked to obesity and metabolic syndrome. Pharmacological suppression of PAI-1 is a likely way to prevent or treat vascular disease. Reduced PAI-1 levels may result in increased fibrinolysis and an associated bleeding diathesis. PAI-1 was initially identified in the 1980s, and the first reported case of PAI-1 deficiency appeared in 1989. Unambiguous proof that PAI-1 deficiency as a cause of a bleeding disorder has been rare, but use of selective PAI inhibitors (See PAI-749) may clarify this point. Because of lack of standardized commercially available PAI-1 activity assay sensitive in the lowest range, the true prevalence of this rare condition has yet to be established.

PAI-1 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


PAI-1 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 32)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
United States Biological --
-- sales@advtechind.com United States 6123 58

  • ARMAPE
  • MOUSE PAI-1
  • MOUSE PLASMINOGEN ACTIVATOR INHIBITOR-1
  • PAI-1
  • PAI-1, HUMAN
  • PAI-1, MOUSE
  • PAI-1, MUTANT, MOUSE
  • PAI-1, RAT
  • PLASMINOGEN ACTIVATOR INHIBITOR-1, HUMAN
  • PLASMINOGEN ACTIVATOR INHIBITOR-1, HUMAN, RECOMBINANT
  • PLASMINOGEN ACTIVATOR INHIBITOR 1
  • PLASMINOGEN ACTIVATOR INHIBITOR-1, MUTANT, MOUSE
  • PLASMINOGEN ACTIVATOR INHIBITOR-1, MUTANT, MOUSE, RECOMBINANT
  • PLASMINOGEN ACTIVATOR INHIBITOR-1, RAT
  • PLASMINOGEN ACTIVATOR INHIBITOR-1, RAT, RECOMBINANT
  • Plasminogen Activator Inhibitor Type 1, active, Mouse Assay Kit, BioAssay&trade
  • Plasminogen Activator Inhibitor Type 1, active, Rat Assay Kit, BioAssay&trade
  • Plasminogen Activator Inhibitor Type 1, active, Human, Assay Kit, BioAssay&trade
  • Plasminogen Activator Inhibitor Type 1, active, Rabbit Assay Kit, BioAssay&trade
  • Plasminogen Activator Inhibitor Type 1, Mouse Assay Kit, BioAssay&trade
  • Plasminogen Activator Inhibitor Type 1, active, Porcine Assay Kit, BioAssay&trade
  • enzyme
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