YC-1
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- CAS-Nr.
- 170632-47-0
- Englisch Name:
- YC-1
- Synonyma:
- YC-1;CS-2261;Nsc728165;LIFICIGUAT;Lificiguat(YC-1);YC-1(Lificiguat);YC 1 (pharMaceutical);YC-1 - CAS 170632-47-0 - Calbiochem;1-Benzyl-3-(5-hydroxymethylfur-2-yl)indazole;1-benzyl-3-(5-hydroxymethyl-2-furyl)indazole
- CBNumber:
- CB2395371
- Summenformel:
- C19H16N2O2
- Molgewicht:
- 304.34
- MOL-Datei:
- 170632-47-0.mol
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YC-1 Eigenschaften
- Schmelzpunkt:
- 110-112℃
- Siedepunkt:
- 522.2±50.0 °C(Predicted)
- Dichte
- 1.24±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- Löslichkeit
- DMSO: 12 mg/mL
- pka
- 13.83±0.10(Predicted)
- Aggregatzustand
- solid
- Farbe
- white
- Stabilität:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizität (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
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YC-1 Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
YC-1 has been used as a hypoxia-inducible factor 1α (HIF-1α) inhibitor:
- to reduce hypoxia induced Jagged1 expression in cardiomyocytes (CMs)
- to study its effect on progenitor expansion and CD34+ and side population (SP) cell phenotype and on the proliferation rate of cells with an ability to form long term colony forming units
- to study its effect on regulating sphingosine 1-phosphate (S1P) bound to albumin induced plasminogen activator inhibitor 1 (PAI-1) expression by activating Rho/ Rho-associated protein kinase (ROCK) pathway.
Allgemeine Beschreibung
A nitric oxide-independent, superoxide-sensitive activator of soluble guanylyl cyclase. Inhibits platelet adhesion to collagen and acts as an antithrombotic agent. Reported to reduce HIF-1α levels and xenograft growth.
Biochem/physiol Actions
YC-1 activates soluble guanylyl cyclase and prevents platelet aggregation and vascular contraction. It has a potential to treat circulation disorders. YC-1 also has an ability to inhibit hypoxia-inducible factor 1α (HIF-1α) activity in vitro. It acts as a potential antiangiogenic anticancer agent.
YC-1 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
YC-1 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 120)Lieferanten
170632-47-0()Verwandte Suche:
- 2-Furanmethanol, 5-[1-(phenylmethyl)-1H-indazol-3-yl]-
- Nsc728165
- (5-(1-Benzyl-1H-indazol-3-yl)furan-2-yl)Methanol
- YC 1 (pharMaceutical)
- 1-Benzyl-3-(5-hydroxymethylfur-2-yl)indazole
- 1-benzyl-3-(5-hydroxymethyl-furan-2-yl)indazole
- Lificiguat(YC-1)
- 5-[1-(PHENYLMETHYL)-1H-INDAZOL-3-YL]-2-FURANMETHANOL
- 3-(5'-HYDROXYMETHYL-2'-FURYL)-1-BENZYLINDAZOLE
- LIFICIGUAT
- YC-1
- YC-1 (3-(5'-HYDROXYMETHYL-2'-FURYL)-1-BE NZYL INDAZOLE) \ GUANYLYL CYCLASE ACTI
- 1-benzyl-3-(5-hydroxymethyl-2-furyl)indazole
- YC-1 - CAS 170632-47-0 - Calbiochem
- CS-2261
- YC-1(Lificiguat)
- 170632-47-0
- C19H16N2O2
- Cell Signaling and Neuroscience
- Cell Biology
- BioChemical
- Cyclic Nucleotide Metabolism
- G Proteins and Cyclic Nucleotides
- Guanylyl Cyclase Activators
