Chinese english Germany Japanese Korea

2-(Benzylmethylamino)ethylmethyl-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridin-3,5-dicarboxylatmonohydrochlorid

Nicardipine hydrochloride Struktur
54527-84-3
CAS-Nr.
54527-84-3
Bezeichnung:
2-(Benzylmethylamino)ethylmethyl-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridin-3,5-dicarboxylatmonohydrochlorid
Englisch Name:
Nicardipine hydrochloride
Synonyma:
YC-93;dafil;dagan;loxen;lincil;Vasonas;Dacarel;Barizin;Aprovan;NICODEL
CBNumber:
CB1244267
Summenformel:
C26H30ClN3O6
Molgewicht:
515.99
MOL-Datei:
54527-84-3.mol
Request For Quotation

2-(Benzylmethylamino)ethylmethyl-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridin-3,5-dicarboxylatmonohydrochlorid Eigenschaften

Schmelzpunkt:
176-1780C
storage temp. 
2-8°C
Löslichkeit
DMSO: ~1 mg/mL
Aggregatzustand
powder
Farbe
yellow
Merck 
14,6495
Stabilität:
Stable for 1 year from date of purchase as supplied. Solutions in distilled water or ethanol may be stored at -20°C for up to 1 month.
InChIKey
AIKVCUNQWYTVTO-UHFFFAOYSA-N
CAS Datenbank
54527-84-3(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher T
R-Sätze: 23/24/25
S-Sätze: 36/37/39-45
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS-Nr. US7972100
HazardClass  6.1(b)
PackingGroup  III
HS Code  2933399090
Toxizität LD50 in male, female rats (mg/kg): 634, 557 orally; 18.1, 25.0 i.v.; in male, female mice: 634, 650 orally; 20.7, 19.9 i.v. (Odani, Sado)

2-(Benzylmethylamino)ethylmethyl-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridin-3,5-dicarboxylatmonohydrochlorid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.

S-Sätze Betriebsanweisung:

S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).

Beschreibung

Nicardipine is a dihydropyridine L-type calcium channel antagonist that displays antihypertensive and antianginal activity. It is reported to inhibit adenosine A1, A2A, and A3 receptors with Ki values of 19.6, 63.8, and 3.25 μM, respectively, and can inhibit cytochrome P450 3A4 catalytic activity with an IC50 value of 0.148 μM. Additionally, nicardipine has been shown to activate transient receptor potential A1 channels, producing an increase in Ca2+ (EC50 = 0.5 μM).

Chemische Eigenschaften

Yellow Solid

Verwenden

Dihydropyridine calcium channel blocker. Antianginal; antihypertensive

Allgemeine Beschreibung

Nicardipine hydrochloride,1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylicacid methyl 2-[methyl(phenylmethyl)amino]ethylester hydrochloride (Cardene), is a more potent vasodilator ofthe systemic, coronary, cerebral, and renal vasculature andhas been used in the treatment of mild, moderate, and severehypertension. The drug is also used in the management of stableangina.

Sicherheitsprofil

Poison by ingestion, intravenous, and intraperitoneal routes. Moderately toxic by subcutaneous route. Human systemic effects: decreased urine volume or anuria. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx an

2-(Benzylmethylamino)ethylmethyl-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridin-3,5-dicarboxylatmonohydrochlorid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

2-(Benzylmethylamino)ethylmethyl-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridin-3,5-dicarboxylatmonohydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 317)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Yanxi Chemical Co., Ltd. 		+8617531190177
 peter@yan-xi.com China 5993 58
airuikechemical co., ltd. 		+undefined86-15315557071
 sales02@airuikechemical.com China 994 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512
 info@tianfuchem.com China 21695 55
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714
 fandachem@gmail.com China 9352 55
Shandong chuangyingchemical Co., Ltd. 		18853181302
sale@chuangyingchem.com CHINA 5909 58
BOC Sciences 		+1-631-485-4226
inquiry@bocsci.com United States 19553 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427
 sales@conier.com China 47465 58
career henan chemical co 		+86-0371-86658258 15093356674;
 factory@coreychem.com China 29826 58
Hebei Mojin Biotechnology Co., Ltd 		+8613288715578
 sales@hbmojin.com China 12453 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 19892 58

54527-84-3(2-(Benzylmethylamino)ethylmethyl-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridin-3,5-dicarboxylatmonohydrochlorid)Verwandte Suche:

Chlordimethylphenylsilan Benzyltrimethylammoniumchlorid Benzylalkohol Dimethylcarbonat Topotecan hydrochloride Rimantadine Benzylchlorid Dimethylfumarat Dimethylsulfoxid Dimethyl ether 2-(Benzylmethylamino)ethylmethyl-1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)pyridin-3,5-dicarboxylat Ethan Dimethylsulfat N,N-Dimethylformamid Benzyltriethylammoniumchlorid Phenylaceton Sibutramine hydrochloride Dimethyl-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridin-3,5-dicarboxylat
  • methyl 2-(benzyl-methyl-amino)ethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride
  • 2-(benzylmethylamino)ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylatemonohydrochloride
  • Naratriptan HCl
  • 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid Methyl 2-[Methyl(phenylmethyl)amino]ethyl Ester Hydrochloride
  • Antagonyl
  • Barizin
  • Dacarel
  • Vasonas
  • YC-93
  • 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)methyl-2-[methyl(phenylmethyl)amino]-3,5-pyridinedicarboxylic acid ethyl ester hydrochloride
  • Vasonase
  • NICARDIPINE HYDROCHLORIDE (YC-93) CALCIU M CHANNEL ANTAG
  • NICARDIPINE HYDROCHLORIDE MM(CRM STANDARD)
  • YC-93, 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)methyl-2-[methyl(phenylmethyl)amino]-3,5-pyridinedicarboxylic acid ethyl ester hydrochloride
  • Aprovan
  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-diMethyl-4-(3-nitrophenyl)-, 3-Methyl 5-[2-[Methyl(phenylMethyl)aMino]ethyl] ester, hydrochloride
  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-methyl 5-[2-[methyl(phenylmethyl)amino]ethyl] ester, hydrochloride (1:1)
  • 5-pyridinedicarboxylicacid,1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-2-(
  • angioglebil
  • benzylmethylamino)ethylmethylester,monohydrochloride
  • bionicard
  • dafil
  • dagan
  • lincil
  • loxen
  • nicardil
  • perdipina
  • rs-69216
  • PERDIPINE
  • NICODEL
  • NICARDIPINE HCL
  • NICARDIPINE HYDROCHLORIDE
  • YC-93 HCL
  • YC-93 HYDROCHLORIDE
  • 1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITROPHENYL)-3,5-PYRIDINE-DICARBOXYLIC ACID 3-METHYL ESTER 5-[2-(METHYL-(BENZYL)AMINO)ETHYL] ESTER HYDROCHLORIDE
  • 1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITROPHENYL)-3,5-PYRIDINEDICARBOXYLIC ACID METHYL 2- [METHYL-(PHENYLMETHYL)AMINO]ETHYL ESTER HYDROCHLORIDE
  • 1,4-DIHYDRO-2,6-DIMETHYL-4-[3-NITROPHENYL]METHYL-2-[METHYL(PHENYLMETHYL)AMINO]-3,5-PYRIDINEDICARBOXYLIC ACID ETHYL ESTER HYDROCHLORIDE
  • Nicardipine Hydrochloride, 99.0+ % (HPLC)
  • NicardipineHydrochloride>
  • Nicardipine for system suitability
  • Nicardipine hydrochloride USP/EP/BP
  • 3-(2-(Benzyl(methyl)amino)ethyl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride
  • Antagonil, Dagan, Flusemide)
  • Nicardipine HCl (RS69216
  • Nicardipine 13CD3 Hydrochloride
  • Nicardipine HydrochlorideQ: What is Nicardipine Hydrochloride Q: What is the CAS Number of Nicardipine Hydrochloride Q: What is the storage condition of Nicardipine Hydrochloride Q: What are the applications of Nicardipine Hydrochloride
  • Nicardipine Hydrochloride (1463224)
  • 13C,2H3]-Nicardipine Hydrochloride
  • Nicardipine Hydrochloride, ≥ 98.0%
  • 54527-84-3
  • 5427-84-3
  • C26H29N3O6HCl
  • C26H30ClN3O6
  • C25H28ClN3O6
  • C26H29N3O6ClH
  • Inhibitors and Activators
  • Ion Channels
  • Voltage-gated Ion Channels
Copyright 2019 © ChemicalBook. All rights reserved