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Digoxin Produkt Beschreibung

DIGOXIN Struktur
20830-75-5
CAS-Nr.
20830-75-5
Bezeichnung:
Digoxin
Englisch Name:
DIGOXIN
Synonyma:
dokim;Digon;dixina;Grexin;dynamos;lanicor;lenoxin;saroxin;DIGACIN;DIGOXIN
CBNumber:
CB2407221
Summenformel:
C41H64O14
Molgewicht:
780.94
MOL-Datei:
20830-75-5.mol

Digoxin Eigenschaften

Schmelzpunkt:
248 °C
alpha 
25Hg +13.4 to 13.8° (c = 10 in pyridine)
Siedepunkt:
661.93°C (rough estimate)
Dichte
1.1110 (rough estimate)
Brechungsindex
12 ° (C=10, Pyridine)
Flammpunkt:
9℃
storage temp. 
Refrigerator
Löslichkeit
Soluble in dimethyl sulfoxide and methanol.
pka
13.50±0.70(Predicted)
Aggregatzustand
powder
Merck 
14,3167
BRN 
77011
CAS Datenbank
20830-75-5
EPA chemische Informationen
Card-20(22)-enolide, 3-[(O-2,6-dideoxy-.beta.-D- ribo-hexopyranosyl-(1.fwdarw. 4)-O-2,6-dideoxy-.beta.-D- ribo-hexopyranosyl-(1.fwdarw. 4)-2,6-dideoxy-.beta.-D-ribo- hexopyranosyl)oxy]-12,14- dihydroxy-, (3.beta.,5.beta.,12.beta.)- (20830-75-5)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher T,T+,F
R-Sätze: 25-26/27/28-23/25-39/23/24/25-23/24/25-11-28-26
S-Sätze: 22-36/37/39-45-36/37-16-28A
RIDADR  UN 3462 6.1/PG 2
WGK Germany  3
RTECS-Nr. IH6125000
3-10
TSCA  Yes
HazardClass  6.1
PackingGroup  II
HS Code  29389090
Giftige Stoffe Daten 20830-75-5(Hazardous Substances Data)
Bildanzeige (GHS)
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H225 Flüssigkeit und Dampf leicht entzündbar. Entzündbare Flüssigkeiten Kategorie 2 Achtung P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H300 Lebensgefahr bei Verschlucken. Akute Toxizität oral Kategorie 2 Achtung P264, P270, P301+P310, P321, P330,P405, P501
H370 Schädigt die Organe. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 1 Achtung P260, P264, P270, P307+P311, P321,P405, P501
Sicherheit
P210 Von Hitze, heißen Oberflächen, Funken, offenen Flammen und anderen Zündquellenarten fernhalten. Nicht rauchen.
P260 Dampf/Aerosol/Nebel nicht einatmen.
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P311 GIFTINFORMATIONSZENTRUM/Arzt anrufen.
P321 Besondere Behandlung
P301+P310 BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P405 Unter Verschluss aufbewahren.

Digoxin Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R25:Giftig beim Verschlucken.
R26/27/28:Sehr giftig beim Einatmen, Verschlucken und Berührung mit der Haut.

S-Sätze Betriebsanweisung:

S22:Staub nicht einatmen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).

Chemische Eigenschaften

White Crystalline Powder

Verwenden

Cardiotonic

Verwenden

cardiac stimulant

Definition

ChEBI: A cardenolide glycoside that is digitoxin beta-hydroxylated at C-12. A cardiac glycoside extracted from the foxglove plant, Digitalis lanata, it is used to control ventricular rate in atrial fibrillation and in the management of congestive heart failure with atrial fibrillation, but the margin between toxic and therapeutic doses is small.

Trademarks

Lanoxin (GlaxoSmithKline).

Allgemeine Beschreibung

Digitalis (Crystodigin) is isolated fromD. lanata and D. purpurea among other Digitalis spp., and isthe chief active glycoside in digitalis leaf, with 1 mg digitoxinequal to 1 g of digitalis leaf therapy. In patients who missdoses, digitalis is very useful for maintenance therapy becauseof the longer half-life it provides. The longer durationand increased half-life are a result of the lack of the C-12hydroxy that is present in digoxin. In digoxin, this hydroxyplays two roles: (a) it serves as a site for metabolism, whichreduces the compound’s half-life; and (b) it gives more hydrophiliccharacter, which results in greater water solubilityand ease in renal elimination.

Allgemeine Beschreibung

Digoxin (Lanoxin) is a purified digitalis preparationfrom D. lanata and represents the most widely useddigitalis glycoside. This wide use is primarily a result of itsfast onset and short half-life. Position 3 of the steroid is substitutedwith three digitoxose residues that, when removed,provide a genin or aglycone steroid that is still capable of receptorbinding but with altered pharmacokinetics.

Allgemeine Beschreibung

Clear to white crystals or white crystalline powder. Odorless. Used as a cardiotonic drug.

Health Hazard

Material is a digitalis glycoside. Ingestion can cause death. Material is considered super toxic; probable human oral lethal dose is less than 5 mg/kg, a taste (less than 7 drops) for a 70 kg (150 lb.) person. Persons at risk include those taking drugs for thyroid and renal diseases. Quinidine and diuretics taken concurrently with DIGOXIN can be hazardous. It should be used with extreme care during pregnancy and in nursing mothers.

Brandgefahr

Avoid light.

Sicherheitsprofil

A deadly poison by most routes. Human systemic effects by ingestion: anorexia, cardlac arrhythmias, nausea and vomiting, visual field changes, pulse rate decrease, fall in blood pressure. An experimental teratogen. When heated to decomposition it emits acrid and irritating fumes. See also DIGITALIS.

läuterung methode

Crystallise digoxin from aqueous EtOH, aqueous pyridine, EtOH/CHCl3, and dry it in a vacuum at 100o. The melting point depends on heating rate, but when placed in a bath at 260o and heated slowly it decomposes at 265o. In EtOH it has max at 220nm ( 12,800). [Smith J Chem Soc 508 1930, X-ray: Go et al. Cryst Struct Commun 8 149, 1031 1979, Beilstein 18/4 V 381.] HIGHLY TOXIC.

Digoxin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Digoxin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 0)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate

20830-75-5(Digoxin)Verwandte Suche:


  • Digoxin 20830-75-5
  • (3beta,5beta,12beta)-3-((o-2,6-dideoxy-beta-d-ribo-hexapyranosyl-(1-4)-2,6-dide
  • -12,14-dihydroxycard-20(22)-enolide
  • 14-dihydroxy-,(3beta,5beta,12beta)-xopyranosyl)oxy]-1
  • 14-dihydroxy-,(3beta,5beta,12beta)-y)-1
  • -2,6-dideoxy-beta-d-ribo-hexopyranosyl-(1.fwdarw.)-2,6-dideoxy-beta-d-ribo-he
  • dixina
  • dokim
  • dynamos
  • homolle’sdigitalin
  • lanatilin
  • lanicor
  • lanocardin
  • lanoxicaps
  • lenoxicaps
  • lenoxin
  • longdigox
  • neodioxanin
  • oxy-beta-d-ribo-hexopyranosyl-(1-4)-2,6-dideoxy-beta-d-ribo-hexopyranosyl)oxy)
  • rougoxin
  • saroxin
  • sk-digoxin
  • stillacor
  • DIGACIN
  • DIGOXIN, AP
  • DIGOXIN
  • LANACORDIN
  • LANOXIN
  • 20(22),5BETA-CARDENOLID-3BETA,12BETA,14BETA-TRIOL 3BETA-2,6-DIDEOXY-4-O-[2,6-DIDEOXY-4-O-(2,6-DIDEOXY-BETA-D-RIBOHEXOPYRANOSYL)-BETA-D-RIBOHEXOPYRANOSIDE]
  • 12BETA-HYDROXYDIGITOXIN
  • 4-[3-[5-[5-(4,5-DIHYDROXY-6-METHYL-TETRAHYDROPYRAN-2-YL)OXY-4-HYDROXY-6-METHYL-TETRAHYDROPYRAN-2-YL]OXY-4-HYDROXY-6-METHYL-TETRAHYDROPYRAN-2-YL]OXY-12,14-DIHYDROXY-10,13-DIMETHYL-2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17-HEXADECAHYDRO-1H-CYCLOPENTA[A]PHENANTHREN-17-YL]-5H-FURAN-2-ONE
  • Purgoxin
  • Toloxin
  • Vanoxin
  • Card-20(22)-enolide, 3-[(O-2,6-dideoxy-- D-ribo-hexopyranosyl-(1<
  • hexopyranosyl)oxy]-12,14-dihydroxy-,(3β,5β,12β)-
  • (3,5,12)-3-[(O-2,6-Dideoxy--D-ribo-hexopyranosyl-(1-4)-O-2,6-dideoxy--D-ribo-hexopyranosyl-(1-4)-2,6-dideoxy--D-ribo-hexopyranosyl)oxyl]-12,14-dihydroxycard-20(22)-enolide
  • 12β-Hydroxydigitoxin, Digoxin
  • digitaline cristallise
  • digitoxine
  • (3beta,5beta,12beta)-3-((O-2,6-Dideoxy-beta-D-ribo-hexapyranosyl-(1-4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxy)-12,14-dihydroxycard-20(22)-enolide
  • 12β,14β-Dihydroxy-5β-carda-20(22)-enolide-3β-yl 4-O-[4-O-(2,6-dideoxy-β-D-altropyranosyl)-2,6-dideoxy-β-D-altropyranosyl]-2,6-dideoxy-β-D-altropyranoside
  • 3β-[[4-O-[4-O-(2,6-Dideoxy-β-D-ribo-hexopyranosyl)-2,6-dideoxy-β-D-ribo-hexopyranosyl]-2,6-dideoxy-β-D-ribo-hexopyranosyl]oxy]-12β,14-dihydroxy-5β,14β-card-20(22)-enolide
  • 3β-[4-O-[4-O-(2,6-Dideoxy-β-D-ribo-hexopyranosyl)-2,6-dideoxy-β-D-ribo-hexopyranosyl]-2,6-dideoxy-β-D-ribo-hexopyranosyloxy]-12β,14-dihydroxy-5β,14β-carda-20(22)-enolide
  • Digohan
  • Digoxin,95%
  • (3beta,5beta,12beta)-3-[(O-2,6-Dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxyl]-12,14-dihydroxycard-20(22)-enolide
  • Digoxin (250 mg)
  • Methanol (Test Digoxin, 1.0 mg/mL)
  • Digoxin 96%
  • (3β,5β,12β)- 3-[(O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-12,14-dihydroxy-card-20(22)-enolide
  • Digoxin solution
  • Digoxin, >=98%
  • 4-[(3S,5R,8R,9S,10S,12R,13S,14S)-3-[(2S,4S,5R,6R)-5-[(2S,4S,5R,6R)-5-[(2S,4S,5R,6R)-4,5-Dihydroxy-6-methyloxan-2-yl]oxy-4-hydroxy-6-methyl-oxan-2-yl]oxy-4-hydroxy-6-methyl-oxan-2-yl]oxy-12,14-dihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-5H-furan-2-one
  • acygoxin
  • card-20(22)-enolide,3-((o-2,6-dideoxy-beta-d-ribo-hexopyranosyl-(1-4)-o-2,6-di
  • card-20(22)-enolide,3-[(o-2,6-dideoxy-beta-d-ribo-hexopyranosyl-(1.fwdarw.)-o
  • cardoxin
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