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DIGOXIN

DIGOXIN
DIGOXIN structure
CAS No.
20830-75-5
Chemical Name:
DIGOXIN
Synonyms
dokim;Digon;dixina;Grexin;dynamos;lanicor;lenoxin;saroxin;DIGACIN;DIGOXIN
CBNumber:
CB2407221
Molecular Formula:
C41H64O14
Formula Weight:
780.94
MOL File:
20830-75-5.mol

DIGOXIN Properties

Melting point:
248 °C
alpha 
25Hg +13.4 to 13.8° (c = 10 in pyridine)
Boiling point:
661.93°C (rough estimate)
Density 
1.1110 (rough estimate)
refractive index 
12 ° (C=10, Pyridine)
Flash point:
9℃
storage temp. 
Refrigerator
solubility 
Soluble in dimethyl sulfoxide and methanol.
form 
powder
Merck 
14,3167
BRN 
77011
CAS DataBase Reference
20830-75-5
EPA Substance Registry System
Card-20(22)-enolide, 3-[(O-2,6-dideoxy-.beta.-D- ribo-hexopyranosyl-(1.fwdarw. 4)-O-2,6-dideoxy-.beta.-D- ribo-hexopyranosyl-(1.fwdarw. 4)-2,6-dideoxy-.beta.-D-ribo- hexopyranosyl)oxy]-12,14- dihydroxy-, (3.beta.,5.beta.,12.beta.)- (20830-75-5)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  T,T+,F
Risk Statements  25-26/27/28-23/25-39/23/24/25-23/24/25-11-28-26
Safety Statements  22-36/37/39-45-36/37-16-28A
RIDADR  UN 3462 6.1/PG 2
WGK Germany  3
RTECS  IH6125000
3-10
TSCA  Yes
HazardClass  6.1
PackingGroup  II
HS Code  29389090
Hazardous Substances Data 20830-75-5(Hazardous Substances Data)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H300 Fatal if swallowed Acute toxicity,oral Category 1, 2 Danger P264, P270, P301+P310, P321, P330,P405, P501
H370 Causes damage to organs Specific target organ toxicity, single exposure Category 1 Danger P260, P264, P270, P307+P311, P321,P405, P501
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P311 Call a POISON CENTER or doctor/physician.
P321 Specific treatment (see … on this label).
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P405 Store locked up.

DIGOXIN price

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DIGOXIN Chemical Properties,Uses,Production

Chemical Properties

White Crystalline Powder

Uses

cardiac stimulant

Uses

Cardiotonic

Definition

ChEBI: A cardenolide glycoside that is digitoxin beta-hydroxylated at C-12. A cardiac glycoside extracted from the foxglove plant, Digitalis lanata, it is used to control ventricular rate in atrial fibrillation and in the management of congestive heart failure with atrial fibrillation, but the margin between toxic and therapeutic doses is small.

brand name

Lanoxin (GlaxoSmithKline).

General Description

Clear to white crystals or white crystalline powder. Odorless. Used as a cardiotonic drug.

General Description

Digitalis (Crystodigin) is isolated fromD. lanata and D. purpurea among other Digitalis spp., and isthe chief active glycoside in digitalis leaf, with 1 mg digitoxinequal to 1 g of digitalis leaf therapy. In patients who missdoses, digitalis is very useful for maintenance therapy becauseof the longer half-life it provides. The longer durationand increased half-life are a result of the lack of the C-12hydroxy that is present in digoxin. In digoxin, this hydroxyplays two roles: (a) it serves as a site for metabolism, whichreduces the compound’s half-life; and (b) it gives more hydrophiliccharacter, which results in greater water solubilityand ease in renal elimination.

General Description

Digoxin (Lanoxin) is a purified digitalis preparationfrom D. lanata and represents the most widely useddigitalis glycoside. This wide use is primarily a result of itsfast onset and short half-life. Position 3 of the steroid is substitutedwith three digitoxose residues that, when removed,provide a genin or aglycone steroid that is still capable of receptorbinding but with altered pharmacokinetics.

Health Hazard

Material is a digitalis glycoside. Ingestion can cause death. Material is considered super toxic; probable human oral lethal dose is less than 5 mg/kg, a taste (less than 7 drops) for a 70 kg (150 lb.) person. Persons at risk include those taking drugs for thyroid and renal diseases. Quinidine and diuretics taken concurrently with DIGOXIN can be hazardous. It should be used with extreme care during pregnancy and in nursing mothers.

Fire Hazard

Avoid light.

Safety Profile

A deadly poison by most routes. Human systemic effects by ingestion: anorexia, cardlac arrhythmias, nausea and vomiting, visual field changes, pulse rate decrease, fall in blood pressure. An experimental teratogen. When heated to decomposition it emits acrid and irritating fumes. See also DIGITALIS.

Purification Methods

Crystallise digoxin from aqueous EtOH, aqueous pyridine, EtOH/CHCl3, and dry it in a vacuum at 100o. The melting point depends on heating rate, but when placed in a bath at 260o and heated slowly it decomposes at 265o. In EtOH it has max at 220nm ( 12,800). [Smith J Chem Soc 508 1930, X-ray: Go et al. Cryst Struct Commun 8 149, 1031 1979, Beilstein 18/4 V 381.] HIGHLY TOXIC.

DIGOXIN Preparation Products And Raw materials

Raw materials

Preparation Products


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