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Metirosin Produkt Beschreibung

ALPHA-METHYL-L-P-TYROSINE Struktur
672-87-7
CAS-Nr.
672-87-7
Bezeichnung:
Metirosin
Englisch Name:
ALPHA-METHYL-L-P-TYROSINE
Synonyma:
AMPT;Demser;L-AMPT;L-α-MT;METYROSINE;Metirosine;α-Me-Tyr-OH;H-(ME)TYR-OH;L-Metyrosine;α-Me-L-Tyr-OH
CBNumber:
CB2480716
Summenformel:
C10H13NO3
Molgewicht:
195.22
MOL-Datei:
672-87-7.mol

Metirosin Eigenschaften

Schmelzpunkt:
320-340°C dec.
storage temp. 
−20°C
Aggregatzustand
Powder
pka
pKa 2.7 (Uncertain);10.1 (Uncertain)
Farbe
White to pale yellow
Merck 
13,6183
BRN 
2368400
CAS Datenbank
672-87-7(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
R-Sätze: 22-38-40-48/20/22
S-Sätze: 22-24/25
WGK Germany  3
TSCA  No
HS Code  2922504500
Bildanzeige (GHS)
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
Sicherheit
P261 Einatmen von Staub vermeiden.
P281 Vorgeschriebene persönliche Schutzausrüstung verwenden.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

Metirosin Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:

S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.

Chemische Eigenschaften

White Solid

Verwenden

A tyrosine hydroxylase inhibitor. An antihypertensive in pheochromocytoma

Definition

ChEBI: An L-tyrosine derivative that consists of L-tyrosine bering an additional methyl substituent at position 2. An inhibitor of the enzyme tyrosine 3-monooxygenase, and consequently of the synthesis of catecholamines. It is us d to control the symptoms of excessive sympathetic stimulation in patients with pheochromocytoma.

Trademarks

Demser (Merck).

Allgemeine Beschreibung

Metyrosine (α-Methyl-L-tyrosine, Demser). Althoughinhibition of any of the three enzymes involved in CA biosynthesisshould decrease CAs, inhibitors of the first andthe rate-limiting enzyme TH would be the most effective.As such, metyrosine is a much more effective competitiveinhibitor of E and NE production than agents that inhibitany of the other enzymes involved in CA biosynthesis. Itis often possible to “fool” the enzymes into accepting astructurally similar and unnatural substrate such as metyrosine.Metyrosine differs structurally from tyrosine onlyin the presence of an α-methyl group . It is oneexample of a CA-biosynthesis inhibitor in clinical use.Although metyrosine is used as a racemic mixture, it is the (-)isomer that possesses the inhibitory activity.Metyrosine, which is given orally in dosages ranging from 1 to 4 g/day, is used principally for the preoperative managementof pheochromocytoma, chromaffin cell tumorsthat produce large amounts of NE and E. Although theseadrenal medullary tumors are often benign, patients frequentlysuffer hypertensive episodes. Metyrosine reducesthe frequency and severity of these episodes by significantlylowering CA production (35%–80%). The drug ispolar (log P=0.73) and excreted mainly unchanged in theurine. Because of its limited solubility in water caused byintramolecular bonding of the zwitterions, crystalluria is apotential serious side effect. It can be minimized by maintaininga daily urine volume of more than 2 L. Inhibitors ofCA synthesis have limited clinical utility because suchagents nonspecifically inhibit the formation of all CAs andresult in many side effects. Sedation is the most commonside effect of this drug.
A similar example is the use of α-methyl-m-tyrosine inthe treatment of shock. It differs structurally from metyrosineonly in the presence of m-OH instead of p-OH inmetyrosine. This unnatural amino acid is accepted by the enzymesof the biosynthetic pathway and converted tometaraminol (an α-agonist).

Metirosin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Metirosin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 94)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30001 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293
+86 0531-67809011 sales@sdzschem.com CHINA 2995 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23980 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 sales@guangaobio.com CHINA 23049 58
BOC Sciences
1-631-619-7922
1-631-614-7828 inquiry@bocsci.com United States 20115 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 35440 58
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
PharmaBlock Sciences (Nanjing),Inc. 400 025 5188
86-025-86918232 sales_china@pharmablock.com China 6448 55
Meryer (Shanghai) Chemical Technology Co., Ltd. +86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-62670440(Beijing)
+86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing) sh@meryer.com China 40269 62

672-87-7(Metirosin)Verwandte Suche:


  • α-Me-L-Tyr-OH
  • (S)-2-AMINO-2-METHYL-3-(4'-HYDROXYPHENYL)PROPANOIC ACID
  • AMPT
  • ALPHA-METHYLTYROSINE
  • ALPHA-METHYL-L-P-TYROSINE
  • ALPHA-METHYL-L-TYR
  • ALPHA-METHYL-L-TYROSINE
  • A-METHYL-L-P-TYROSINE
  • H-(ME)TYR-OH
  • (S)-a-Methyltyrosine
  • α-Me-Tyr-OH
  • α-Methyl-L-p-tyrosine
  • (S)-α-Methyltyrosine, 98% ee
  • (2S)-2-amino-3-(4-hydroxyphenyl)-2-methylpropanoic acid
  • Alpha-Methyl-Tyr-OH
  • L-alfa-Me-Tyr-OH
  • L-2-METHYL-3-[4-HYDROXYPHENYL]-ALANINE
  • METYROSINE
  • Metirosine
  • 2-Methyl-L-Tyrosine
  • α-Methyl-L-tyrosine
  • L-ALPHA-METHYLTYROSINE, 98%
  • AMPT,Metyrosine,
  • -Methyl-L-Tyr
  • A-METHYL-L-TYR
  • A-METHYL-L-TYROSINE
  • L-2-Me-Tyr-OH
  • ALPHA-METHYL-L-P-TRYOSINE
  • (S)-alpha-Methyl-4-hydroxy phenylalanine, (S)-a-Methyltyrosine (>98%, >98%ee)
  • H-alpha-Me-L-Tyr-OH
  • a-Methyl-L-p-tyrosineDiscontinued
  • L-2-Methyl-3-(4-hydroxyphenyl)alanine, L-AMPT
  • L-α-Methyltyrosine
  • α-Methyl-L-tyrosine, L-2-Methyl-3-(4-hydroxyphenyl)alanine, L-AMPT
  • (S)-3-(2-Methyl-4-hydroxyphenyl)-2-aminopropionic acid
  • Demser
  • L-AMPT
  • L-α-Methylrosine
  • (S)-alpha-Methyltyrosine, 98% ee, 98%
  • Metyrosine (200 mg)
  • L-2-Me-Tyr-OH α-Methyl-L-tyrosine
  • (S)-2-(4-Hydroxybenzyl)-2-aMinopropanoic Acid
  • (S)-α-Methyltyrosine
  • L(-)-Metyrosine
  • L-Metyrosine
  • L-α-Methyl-p-tyrosine
  • L-α-MT
  • (S)-alpha-Methyltyrosine, 98%, 98% ee
  • 672-87-7
  • C10H13NO3
  • Tyrosine hydroxylase inhibitor.
  • Peptide Synthesis
  • Tyrosine Derivatives
  • Unnatural Amino Acid Derivatives
  • Specialty Synthesis
  • AMINE
  • -
  • α-Methyl Amino Acids
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