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ALPHA-METHYL-L-P-TYROSINE

ALPHA-METHYL-L-P-TYROSINE 구조식 이미지
카스 번호:
672-87-7
상품명:
ALPHA-METHYL-L-P-TYROSINE
동의어(영문):
AMPT;Demser;L-AMPT;L-α-MT;METYROSINE;Metirosine;α-Me-Tyr-OH;H-(ME)TYR-OH;L-Metyrosine;α-Me-L-Tyr-OH
CBNumber:
CB2480716
분자식:
C10H13NO3
포뮬러 무게:
195.22
MOL 파일:
672-87-7.mol

ALPHA-METHYL-L-P-TYROSINE 속성

녹는점
320-340°C dec.
저장 조건
−20°C
물리적 상태
Powder
산도 계수 (pKa)
pKa 2.7 (Uncertain);10.1 (Uncertain)
색상
White to pale yellow
Merck
13,6183
BRN
2368400
CAS 데이터베이스
672-87-7(CAS DataBase Reference)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험 카페고리 넘버 22-38-40-48/20/22
안전지침서 22-24/25
WGK 독일 3
TSCA No
HS 번호 2922504500
그림문자(GHS):
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H315 피부에 자극을 일으킴 피부부식성 또는 자극성물질 구분 2 경고 P264, P280, P302+P352, P321,P332+P313, P362
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 P264, P280, P305+P351+P338,P337+P313P
예방조치문구:
P261 분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P281 요구되는 개인 보호구를 착용하시오
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

ALPHA-METHYL-L-P-TYROSINE C화학적 특성, 용도, 생산

화학적 성질

White Solid

용도

A tyrosine hydroxylase inhibitor. An antihypertensive in pheochromocytoma

정의

ChEBI: An L-tyrosine derivative that consists of L-tyrosine bering an additional methyl substituent at position 2. An inhibitor of the enzyme tyrosine 3-monooxygenase, and consequently of the synthesis of catecholamines. It is us d to control the symptoms of excessive sympathetic stimulation in patients with pheochromocytoma.

상표명

Demser (Merck).

일반 설명

Metyrosine (α-Methyl-L-tyrosine, Demser). Althoughinhibition of any of the three enzymes involved in CA biosynthesisshould decrease CAs, inhibitors of the first andthe rate-limiting enzyme TH would be the most effective.As such, metyrosine is a much more effective competitiveinhibitor of E and NE production than agents that inhibitany of the other enzymes involved in CA biosynthesis. Itis often possible to “fool” the enzymes into accepting astructurally similar and unnatural substrate such as metyrosine.Metyrosine differs structurally from tyrosine onlyin the presence of an α-methyl group . It is oneexample of a CA-biosynthesis inhibitor in clinical use.Although metyrosine is used as a racemic mixture, it is the (-)isomer that possesses the inhibitory activity.Metyrosine, which is given orally in dosages ranging from 1 to 4 g/day, is used principally for the preoperative managementof pheochromocytoma, chromaffin cell tumorsthat produce large amounts of NE and E. Although theseadrenal medullary tumors are often benign, patients frequentlysuffer hypertensive episodes. Metyrosine reducesthe frequency and severity of these episodes by significantlylowering CA production (35%–80%). The drug ispolar (log P=0.73) and excreted mainly unchanged in theurine. Because of its limited solubility in water caused byintramolecular bonding of the zwitterions, crystalluria is apotential serious side effect. It can be minimized by maintaininga daily urine volume of more than 2 L. Inhibitors ofCA synthesis have limited clinical utility because suchagents nonspecifically inhibit the formation of all CAs andresult in many side effects. Sedation is the most commonside effect of this drug.
A similar example is the use of α-methyl-m-tyrosine inthe treatment of shock. It differs structurally from metyrosineonly in the presence of m-OH instead of p-OH inmetyrosine. This unnatural amino acid is accepted by the enzymesof the biosynthetic pathway and converted tometaraminol (an α-agonist).

ALPHA-METHYL-L-P-TYROSINE 준비 용품 및 원자재

원자재

준비 용품


ALPHA-METHYL-L-P-TYROSINE 공급 업체

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